Biochemistry
9th Edition
ISBN: 9781305961135
Author: Mary K. Campbell, Shawn O. Farrell, Owen M. McDougal
Publisher: Cengage Learning
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Chapter 4, Problem 38RE
Interpretation Introduction
Interpretation:
Whether a fetus homozygous for sickle cell hemoglobin (Hb S) has normal Hb F or not, is to be determined.
Concept Introduction:
Sickle cell trait is a condition where a person possesses one abnormal allele of hemoglobin.
Sickle cell trait is found in people who have one sickle cell gene and one normal gene as well.
The symptoms of sickle cell disease (SCD) are not expressed always, but are passed to the next generation.
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Biochemistry
Ch. 4 - RECALL Match the following statements about...Ch. 4 - RECALL Define denaturation in terms of the effects...Ch. 4 - RECALL What is the nature of random structure in...Ch. 4 - REFLECT AND APPLY Suggest an explanation for the...Ch. 4 - REFLECT AND APPLY Rationalize the following...Ch. 4 - REFLECT AND APPLY Glycine is a highly conserved...Ch. 4 - REFLECT AND APPLY A mutation that changes an...Ch. 4 - REFLECT AND APPLY A biochemistry student...Ch. 4 - RECALL List three major differences between...Ch. 4 - RECALL What are Ramachandran angles?
Ch. 4 - Prob. 11RECh. 4 - Prob. 12RECh. 4 - RECALL List some of the differences between the...Ch. 4 - RECALL List some of the possible combinations of...Ch. 4 - RECALL Why is proline frequently encountered at...Ch. 4 - RECALL Why must glycine be found at regular...Ch. 4 - REFLECT AND APPLY You hear the comment that the...Ch. 4 - REFLECT AND APPLY Woolen clothing shrinks when...Ch. 4 - RECALL Draw two hydrogen bonds, one that is part...Ch. 4 - RECALL Draw a possible electrostatic interaction...Ch. 4 - RECALL Draw a disulfide bridge between two...Ch. 4 - RECALL Draw a region of a polypeptide chain...Ch. 4 - REFLECT AND APPLY The terms configuration and...Ch. 4 - REFLECT AND APPLY Theoretically, a protein could...Ch. 4 - REFLECT AND APPLY What is the highest level of...Ch. 4 - RECALL List two similarities and two differences...Ch. 4 - RECALL What are the two critical amino acids near...Ch. 4 - RECALL What is the highest level of organization...Ch. 4 - RECALL Suggest a way in which the difference...Ch. 4 - RECALL Describe the Bohr effect.Ch. 4 - RECALL Describe the effect of 2,...Ch. 4 - RECALL How does the oxygen-binding curve of fetal...Ch. 4 - RECALL What is the critical amino acid difference...Ch. 4 - REFLECT AND APPLY In oxygenated hemoglobin,...Ch. 4 - REFLECT AND APPLY You are studying with a friend...Ch. 4 - REFLECT AND APPLY How does the difference between...Ch. 4 - REFLECT AND APPLY Suggest a reason for the...Ch. 4 - Prob. 38RECh. 4 - REFLECT AND APPLY Why is fetal Hb essential for...Ch. 4 - BIOCHEMICAL CONNECTIONS Why might you expect to...Ch. 4 - REFLECT AND APPLY When deoxyhemoglobin was first...Ch. 4 - BIOCHEMICAL CONNECTIONS What is the direct cause...Ch. 4 - BIOCHEMICAL CONNECTIONS What is the effect of the...Ch. 4 - BIOCHEMICAL CONNECTIONS Why do scientists believe...Ch. 4 - Prob. 45RECh. 4 - BIOCHEMICAL CONNECTIONS What is BCL11A and how is...Ch. 4 - BIOCHEMICAL CONNECTIONS Given the purpose of...Ch. 4 - Prob. 48RECh. 4 - REFLECT AND APPLY Comment on the energetics of...Ch. 4 - RECALL What is a chaperone?Ch. 4 - Prob. 52RECh. 4 - Prob. 53RECh. 4 - Prob. 54RECh. 4 - RECALL What are some diseases caused by misfolded...Ch. 4 - RECALL What causes protein aggregates to form?Ch. 4 - Prob. 57RECh. 4 - Prob. 58RECh. 4 - BIOCHEMICAL CONNECTIONS What aspects of the...Ch. 4 - Prob. 60RECh. 4 - Prob. 61RE
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- REFLECT AND APPLY Why is fetal Hb essential for the survival of placental animals?arrow_forwardREFLECT AND APPLY How does the difference between the -chain and the -chain of hemoglobin explain the differences in oxygen binding between Hb A and Hb F?arrow_forwardREFLECT AND APPLY You are studying with a friend who is describing the Bohr effect. She tells you that in the lungs, hemoglobin binds oxygen and releases hydrogen ion; as a result, the pH in- creases. She goes on to say that in actively metabolizing muscle tissue, hemoglobin releases oxygen and binds hydrogen ion and, as a result, the pH decreases. Do you agree with her reasoning? Why or why not?arrow_forward
- REFLECT AND APPLY Is the following statement true or false? Why? The flow of genetic information in the cell is always DNARNAprotein.arrow_forwardREFLECT AND APPLY Given the typing speed from Question 37, how long must you type, nonstop, at the fidelity shown by E. coli (see Question 36) before an uncorrected error would be permitted?arrow_forwardRECALL Suggest a way in which the difference between the functions of hemoglobin and myoglobin is reflected in the shapes of their respective oxygen-binding curves.arrow_forward
- REFLECT AND APPLY In oxygenated hemoglobin, pKa=6.6 for the histidines at position 146 on the -chain. In deoxygenated hemoglobin, the pKa of these residues is 8.2. How can this piece of information be correlated with the Bohr effect?arrow_forwardREFLECT AND APPLY Outline the methods you would use to pro- duce human growth hormone (a substance used in the treatment of dwarfism) in bacteria.arrow_forwardREFLECT AND APPLY Suggest a reason for the observation that people with sickle-cell trait sometimes have breathing problems during high-altitude flights.arrow_forward
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