Principles of Anatomy and Physiology
15th Edition
ISBN: 9781119329398
Author: Gerard J Tortora, Bryan Derrickson
Publisher: John Wiley & Sons Inc
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Textbook Question
Chapter 4, Problem 18CP
Which types of muscular tissue are striated? Which is smooth?
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1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple different routes of administration provides greater insight than just a single route of administration alone. The following data was collected in 250 g rats following bolus iv, oral (po), and intraperitoneal (ip) administration.Using this data and set of graphs, determine:
(a) k, C0, V, and AUC* for the bolus iv data (b) k, ka, B1, and AUC* for the po data (c) k, ka, B1, and AUC* for the ip data (d) relative bioavailability for po vs ip, Fpo/Fip (e) absolute po bioavailability, (f)Fpo absolute ip bioavailability, Fip
MAKE SURE ANSWERS HAVE UNITS if appropriate.
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2. Drug quantification from plasma is commonly performed by using techniques such as HPLC or LC/MS. However, these methods do have limitations, and investigators may choose to use a radiolabeled analog of a drug instead. Radioligands are molecules that contain radioactive isotopes, commonly 3H or 14C. This technique allows investigators to quantify drug concentration from radiation measurements. The following measurements were made in 250 g rats following oral administration of 18.2 µCi of a 14C-labeled drug of interest: Time (min) Plasma Radiation Levels (µCi/L) 0 0.0 2 9.7 4 19.2 7 25.3 9 37.8 12 39.6 14 45.8 17 48.8 20 52.0 25 56.4 30 59.2 35 60.1 40 61.1 45 62.1 50 62.8 60 63.1 70 62.1 80 60.1 90 57.3 100 55.5 110 53.7 120 52.2 150 48.0 180 45.0 240 39.0
Note that a µCi is a measure of the amount of radioactivity and hence is a measure of the amount of drug present. Given that the oral bioavailability of this drug is known to be essentially 100%, estimate the following from this…
The current nutrition labelling regulation in Hong Kong requires food manufacturer to list E+7 information on the package of pre-packaged food products. Do you think that more nutrients, such as calcium and cholesterol, shall be included?
Chapter 4 Solutions
Principles of Anatomy and Physiology
Ch. 4 - l. Define a tissue.
Ch. 4 - What are the four basic types of human tissues?Ch. 4 - 3. Which type of cell junction prevents the...Ch. 4 - Which types of cell junctions are found in...Ch. 4 - 5. Why are epithelial and connective tissues found...Ch. 4 - Describe the various layering arrangements and...Ch. 4 - What characteristics are common to all epithelial...Ch. 4 - Checkpoint 8:
How is the structure of the...Ch. 4 - Where are endothelium and mesothelium located?Ch. 4 - Prob. 10CP
Ch. 4 - In what ways does connective tissue differ from...Ch. 4 - What are the features of the cells, ground...Ch. 4 - 13. How are connective tissues classified? List...Ch. 4 - Describe how the structure of the following...Ch. 4 - What is the difference between interstitial and...Ch. 4 - 16. Define the following kinds of membranes:...Ch. 4 - Where is each type of membrane located in the...Ch. 4 - 18. Which types of muscular tissue are striated?...Ch. 4 - Which types of muscular tissue have gap junctions?Ch. 4 - 20. What are the functions of the dendrites, cell...Ch. 4 - 21. Why is electrical excitability important to...Ch. 4 - 22. How are stromal and parenchymal repair of a...Ch. 4 - What is the importance of granulation tissue?Ch. 4 - 24. What common changes occur in epithelial and...Ch. 4 - 1. Imagine that you live 50 years in the future,...Ch. 4 - 2. You are entering a “Cutest Baby Contest” and...Ch. 4 - Prob. 3CTQ
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