Concept explainers
a.
To determine: The figure of parents and progeny classes from a cross PM"'/ pM' x pM'/pM"".
Introduction: A PCR banding pattern is shown for a family with six children, and this pattern is interpreted at the top of the illustration with the use of four differently sized molecular "alleles;· M' through M"". One ofthese markers (M") is probably linked in cis configuration to the disease allele P.
b.
To determine: There no M'M" individuals in the progeny.
Introduction: A molecular marker is a molecule contained within a sample taken from an organism or other matter. It can be used to reveal certain characteristics about the respective source.
c.
To determine: The exceptions to the rule that P is associated with M".
Introduction: An allele is a variant form of a given gene, meaning it is one of two or more versions of a known mutation at the same place on a chromosome.
d.
To determine: The two DNA bands shown for each progeny individual.
Introduction: The molecular marker "alleles" are detected using a technique called the polymerase chain reaction (PCR). For now, simply recognize that PCR allows different numbers of tandem repeats to be detected as differently sized products on an electrophoretic gel

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Chapter 4 Solutions
INTRO.TO GENETIC ANALYSIS (LL)-W/ACCESS
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- Choose a catecholamine neurotransmitter and describe/draw the components of the synapse important for its signaling including synthesis, packaging into vesicles, receptors, transporters/degradative enzymes. Describe 2 drugs that can act on this system.arrow_forwardThe following figure is from Caterina et al. The capsaicin receptor: a heat activated ion channel in the pain pathway. Nature, 1997. Black boxes indicate capsaicin, white circles indicate resinferatoxin. a) Which has a higher potency? b) Which is has a higher efficacy? c) What is the approximate Kd of capsaicin in uM? (you can round to the nearest power of 10)arrow_forwardWhat is the rate-limiting-step for serotonin synthesis?arrow_forward
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