Campbell Biology in Focus; Modified Mastering Biology with Pearson eText -- ValuePack Access Card -- for Campbell Biology in Focus (2nd Edition)
2nd Edition
ISBN: 9780134433776
Author: Lisa A. Urry, Michael L. Cain, Steven A. Wasserman
Publisher: PEARSON
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Chapter 38, Problem 8TYU
SCIENTIFIC INQUIRY
Consider an individual who had been fluent in American Sign Language before suffering an injury to his left cerebral hemisphere. After the injury, he could still understand signs but could not readily generate signs that represented his thoughts. Propose two hypotheses that could explain this finding. How might you distinguish between them?
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1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple different routes of administration provides greater insight than just a single route of administration alone. The following data was collected in 250 g rats following bolus iv, oral (po), and intraperitoneal (ip) administration.Using this data and set of graphs, determine:
(a) k, C0, V, and AUC* for the bolus iv data (b) k, ka, B1, and AUC* for the po data (c) k, ka, B1, and AUC* for the ip data (d) relative bioavailability for po vs ip, Fpo/Fip (e) absolute po bioavailability, (f)Fpo absolute ip bioavailability, Fip
MAKE SURE ANSWERS HAVE UNITS if appropriate.
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2. Drug quantification from plasma is commonly performed by using techniques such as HPLC or LC/MS. However, these methods do have limitations, and investigators may choose to use a radiolabeled analog of a drug instead. Radioligands are molecules that contain radioactive isotopes, commonly 3H or 14C. This technique allows investigators to quantify drug concentration from radiation measurements. The following measurements were made in 250 g rats following oral administration of 18.2 µCi of a 14C-labeled drug of interest: Time (min) Plasma Radiation Levels (µCi/L) 0 0.0 2 9.7 4 19.2 7 25.3 9 37.8 12 39.6 14 45.8 17 48.8 20 52.0 25 56.4 30 59.2 35 60.1 40 61.1 45 62.1 50 62.8 60 63.1 70 62.1 80 60.1 90 57.3 100 55.5 110 53.7 120 52.2 150 48.0 180 45.0 240 39.0
Note that a µCi is a measure of the amount of radioactivity and hence is a measure of the amount of drug present. Given that the oral bioavailability of this drug is known to be essentially 100%, estimate the following from this…
The current nutrition labelling regulation in Hong Kong requires food manufacturer to list E+7 information on the package of pre-packaged food products. Do you think that more nutrients, such as calcium and cholesterol, shall be included?
Chapter 38 Solutions
Campbell Biology in Focus; Modified Mastering Biology with Pearson eText -- ValuePack Access Card -- for Campbell Biology in Focus (2nd Edition)
Ch. 38.1 - Which division of the autonomic nervous system...Ch. 38.1 - Prob. 2CCCh. 38.2 - When you wave your right hand, what part of your...Ch. 38.2 - People who are inebriated have difficulty touching...Ch. 38.2 - WHAT IF? Two groups of individuals have CNS...Ch. 38.3 - Prob. 1CCCh. 38.3 - Prob. 2CCCh. 38.3 - WHAT IF? If a woman with a severed corpus callosum...Ch. 38.4 - Which one of the five categories of sensory...Ch. 38.4 - Prob. 2CC
Ch. 38.4 - WHAT IF? If you stimulated a sensory neuron of an...Ch. 38.5 - Prob. 1CCCh. 38.5 - Prob. 2CCCh. 38.5 - Prob. 3CCCh. 38.5 - Prob. 4CCCh. 38.6 - Contrast the light-detecting organs of planarians...Ch. 38.6 - Prob. 2CCCh. 38.6 - MAKE CONNECTIONS Compare the function of retinal...Ch. 38 - Patients with damage to Wernickes area have...Ch. 38 - The cerebral cortex does not play a major role in...Ch. 38 - The middle ear converts A. air pressure waves to...Ch. 38 - Prob. 4TYUCh. 38 - Prob. 5TYUCh. 38 - Prob. 6TYUCh. 38 - Prob. 7TYUCh. 38 - SCIENTIFIC INQUIRY Consider an individual who had...Ch. 38 - Prob. 9TYUCh. 38 - FOCUS ON ORGANIZATION In a short essay (100-150...Ch. 38 - Prob. 11TYU
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