EBK CAMPBELL BIOLOGY IN FOCUS
2nd Edition
ISBN: 8220101459299
Author: Reece
Publisher: PEARSON
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Chapter 37, Problem 11TYU
FOCUS ON EVOLUTION
An action potential is an all-or-none event. This on/off signaling is an evolutionary adaptation of animals that must sense and act in a complex environment. It is possible to imagine a nervous system in which the action potentials are graded, with the amplitude depending on the size of the stimulus. Describe what evolutionary advantage on/off signaling might have over a graded (continuously variable) kind of signaling.
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Graded (Local)
Potentials
All or none
Do not reach threshold
Change in RMP
Size depends on size of stimulus
Chemically or mechanically gated
channels
Decreases in intensity
Found in axon
Found in dendrites
Involve gated channels
Involve K+ diffusion
Involve Na+ diffusion
Self-propagating
Has a threshold
Action Potentials
Voltage gated channels
Local signaling
Long distance signaling
Put the steps of the process of signal transduction in the order they occur (hint - try to decide
which signaling pathway this is before working on the order):
1. A conformational change in the signal-receptor complex activates an enzyme.
2. Protein kinases are activated.
3. A signal molecule binds to a receptor.
4. Target proteins are phosphorylated.
5. Second messenger molecules are released.
O 1, 2, 3, 4, 5
O 3, 1, 2, 4, 5
O 1, 2, 5, 3, 4
O 3, 1, 5, 2, 4
I
a scientist that works on autism and you think that the mutation in the sodium channel found in 3 of your patients can be one of the causes for this disorder. Describe an experiment you could do to test this hypothesis.
the scientist need to be specific from the beginning of of the experiment by identifying the mutation to the end including experiment, propagation of action potential, its effect on signal transmission and synapse and give an example of the phenotype you anticipate to observe
Chapter 37 Solutions
EBK CAMPBELL BIOLOGY IN FOCUS
Ch. 37.1 - Prob. 1CCCh. 37.1 - Describe the basic pathway of information flow...Ch. 37.1 - WHAT IF? How might increased branching of an axon...Ch. 37.2 - Under what circumstances could ions flow through...Ch. 37.2 - WHAT IF? Suppose a cells membrane potential shifts...Ch. 37.2 - Prob. 3CCCh. 37.3 - How do action potentials and graded potentials...Ch. 37.3 - In multiple sclerosis (from the Greek skleros,...Ch. 37.3 - Prob. 3CCCh. 37.3 - WHAT IF? Suppose a mutation caused gated sodium...
Ch. 37.4 - Prob. 1CCCh. 37.4 - Organophosphate pesticides work by inhibiting...Ch. 37.4 - MAKE CONNECTIONS Name one or more membrane...Ch. 37 - What happens when a resting neuron's membrane...Ch. 37 - Prob. 2TYUCh. 37 - Prob. 3TYUCh. 37 - Why are action potentials usually conducted in one...Ch. 37 - Which of the following is a direct result of...Ch. 37 - Suppose a particular neurotransmitter causes an...Ch. 37 - Prob. 7TYUCh. 37 - Prob. 8TYUCh. 37 - DRAW IT Suppose a researcher inserts a pair of...Ch. 37 - Prob. 10TYUCh. 37 - FOCUS ON EVOLUTION An action potential is an...Ch. 37 - Prob. 12TYUCh. 37 - SYNTHESIZE YOUR KNOWLEDGE The rattlesnake alerts...
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- You learned in this chapter that Na+/K+ active transport pumps in the plasma membrane of the axons are responsible for creating the imbalance between Na+ and K+ inside and outside of the neuron that produces the resting membrane potential. In early research studying the role of ions and the involvement of active transport of ions in neural signaling, investigators used the giant axon of a squid as a model. The diameter of a giant axon is far greater than that of a mammalian axon, which enabled researchers to isolate it easily and use it in in vitro experiments. In one early experiment, researchers investigated the active transport of Na+ out of the axon in response to the presence of cyanide. Experimentally they hooked up a section of axon to a syringe, immersed the axon in artificial seawater, introduced radioactive 22Na (as 22NaCl) into the axon, and then quantified the transport of 22Na out through the axons plasma membrane. The rate of 22Na transport out of the axon was determined by measuring the radioactivity released into the fluid sur- rounding the axon over a period of time. The Figure shows the results of the experiment. What is the effect of cyanide on Na1 transport out of the squid axon? How do the data show the effect? Source: P. C. Caldwell et al. 1960. The effects of injecting energy-rich phosphate compounds on the active transport of ions in the giant axons of Loligo. The Journal of Physiology 152:561590. Cengage Learning 2017arrow_forwardPut the steps of the process of G-protein signal transduction in the order (1-4) in which they occur. Second messenger molecules are activated and amplify the signal A signal molecule binds to a receptor on the outside of the cell The alpha (a) subunit of the G-protein inside the cell moves and binds to a nearby enzyme The receptor changes shape, transducing the signal into the cellarrow_forwardNeed help Different behavior patterns can be created by interactions of one or more pattern generators - in response to light touch, the sea slug, Tritonia, exhibits reflexive withdrawal of the body away from the stimulus (i.e. the sea slug “cringes”). However, a stronger mechanical stimulus induces the release of serotonin from specific neurons within the central nervous system and subsequent swimming behavior (i.e., an escape response). Both withdrawals of the body and swimming are driven by the same central pattern generator circuitry. This illustrates which important characteristic of central pattern generators? A. Model central pattern generators are not as complex as their real-world counterparts. B. Their rhythmic output is an emergent property of the neural network. C. Their output is not fixed but can be modifiedarrow_forward
- The giant squid axon has a diameter = 1mm and 1 = 13mm. Compared to a mammalian neuron with a diameter = 1 um and ^ = 0.2mm, which of the following is correct? graded potentials can generate action potentials in the mammalian axon but not in the squid axon. graded potential of similar magnitude would result in action potentials with larger amplitude in the mammalian axon graded potentials of similar magnitude would result in action potentials with larger amplitude in the squid axon graded potentials of similar magnitude would travel furthest from their point of origin in the mammalian axon graded potentials of similar magnitude would travel furthest from their point of origin in the squid axonarrow_forwardWhen a signal binds to the Tyrosine kinase receptor (RTK), you have studied that a list of events occur sequentially. Map the events in the correct order from 1st to the last step.arrow_forwardThe figure below shows a signaling pathway activated by the bindiıng of adrehalMNe LU the beta-adrenergic receptor. Binding of adrenaline to the receptor causes GTP-binding and activation of G proteins. Active GTP-bound G protein activates adenylate cyclase to initiate a signaling cascade that affects cellular responses, and includes cellular changes to mediate increased heart rate and accounts for the flight-or-fight response. activated adenylate cyclase adrenaline activated B-adrenergic receptor adenylate cyclase G protein subunit 22 GTP SDP conformational ATP CAMP change in receptor heterotrimeric G protein ACAMP inactive protein kinase A active protein kinase A 4 cellular responses Consider the homozygous mutation in which a cell produces a variant of adenylate cyclase that can no longer be activated Which of the following are true in this cell? Select all that apply. Heart rate increases Protein Kinase A is not activated CAMP levels are lower than normal Heart rate decreasesarrow_forward
- Except for?, all of the following signals may trigger receptor conformational changes without reaching the plasma membrane. o a. Receptors for steroid hormones. Tyrosine kinase receptors are a kind of receptor that binds to tyrosine phosphatase. Voltage-gated ion channels (OC). G protein-coupled receptors (GPCRs).arrow_forwardWhich membrane proteins are involved in the potentiation of the membrane signalling that travels along a nerve cell? Na* channels Nat/K* pumps K* carriers Ca2+ channelsarrow_forwardCompound C is a pharmaceutical agent that blocks AMPK activity. How might compound C influence adaptation following resistance exercise? How might compound C influence adaptation following endurance exercise? Be specific and remember this section is Molecular Signalingarrow_forward
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Intro to Cell Signaling; Author: Amoeba Sisters;https://www.youtube.com/watch?v=-dbRterutHY;License: Standard youtube license