EP CONNECT ONLINE ACCESS FOR BIOLOGY:
5th Edition
ISBN: 9781260542226
Author: Hoefnagels
Publisher: MCGRAW-HILL HIGHER EDUCATION
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Chapter 3.5, Problem 2MC
Summary Introduction
To describe:
The main components of the cytoskeleton.
Concept introduction:
Cytoskeleton includes a network of the protein filaments which are involved in the maintaining the structural framework of the cell. They are characterized on the basis of their thickness, diameter and ability to form a network of the fibers in the cytoplasm.
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Digoxin: Intravenous Bolus - Two Compartment Model
Drug
Digoxin
Route:
IV Bolus
Dose:
0.750 mg
Plasma Concentration Time Profile
Beta
Alpha
Time (hrs)
Conc (ng/ml)
LN
(ng/ml)
LN
(ng/ml)
LN
0.00
#NUM!
#NUM!
#NUM!
0.10
12.290
2.509
#NUM!
#NUMI
0.60
6.975
1.942
#NUM!
#NUMI
1.00
4.649
1.537
#NUM!
#NUMI
2.00
2.201
0.789
#NUM!
#NUM!
3.00
1.536
0.429
#NUM!
#NUM!
4.00
1.342
0.294
#NUM!
#NUM!
5.00
1.273
0.241
#NUM!
#NUMI
6.00
1.238
0.213
#NUM!
#NUM!
7.00
1.212
0.192
#NUM!
#NUM!
8.00
1.188
0.172
#NUMI
#NUM!
9.00
1.165
0.153
#NUM!
#NUMI
10.00
1.143
0.134
#NUMI
#NUM!
11.00
1.122
0.115
#NUM!
12.00
1.101
0.096
#NUMI
13.00
1.080
0.077
#NUMI
16.00
1.020
0.020
#NUMI
24.00
0.876
-0.132
#NUMI
Pharmacokinetic Parameters
Parameter
Value
Alpha
B
Beta
Units
ng/ml
hr-1
ng/ml
hr-1
CO
ng/ml
H.C
AUC
ng x hr/ml
Vc
Vbeta
Vss
C
L/hr
TK (alpha)
hr
TX (beta)
days
5+
F3
F4
F5
0+
F6
F7
%
6
95
14
#3
29
&
t
F8
F9
FW
EW
Linuron, a derivative of urea, is used as an herbicide. Linuron serum levels were measured in 4Kg
rabbits following a bolus IV injection of 10mg/kg.
Time (minutes)
Serum Linuron Levels (ug/ml)
following IV dose
10
15.48
20
8.60
30
5.90
45
3.78
60
2.42
90
1.49
120
0.93
180
0.60
240
0.41
300
0.29
360
0.22
Analyze this data and perform the necessary calculations to determine the following pharmacokinetic
parameters from the IV data: (5 points per parameter, 24 parameters/variables ■ 120 points
possible). You do NOT need to submit graphs or data tables.
Give the terminal regression line equation and R or R² value:
Give the x axis (name and units, if any) of the terminal line:
Give the y axis (name and units, if any) of the terminal line:
Give the residual regression line equation and R or R² value:
Give the x axis (name and units, if any) of the residual line:
Give the y axis (name and units, if any) of the residual line:
Chapter 3 Solutions
EP CONNECT ONLINE ACCESS FOR BIOLOGY:
Ch. 3.1 - Why are cells, not atoms, the basic units of life?Ch. 3.1 - How have microscopes advanced the study of cells?Ch. 3.1 - What are the original components of the cell...Ch. 3.1 - Prob. 4MCCh. 3.1 - Which molecules and structures occur in all cells?Ch. 3.1 - Describe adaptations that increase the ratio of...Ch. 3.2 - How do prokaryotic cells differ from eukaryotic...Ch. 3.2 - Prob. 2MCCh. 3.2 - Prob. 3MCCh. 3.2 - What is the relationship between cells and...
Ch. 3.2 - Prob. 5MCCh. 3.3 - How does the chemical structure of phospholipids...Ch. 3.3 - Where in the cell do phospholipid bilayers occur?Ch. 3.3 - Prob. 3MCCh. 3.3 - Prob. 4MCCh. 3.4 - Prob. 1MCCh. 3.4 - What is the function of the nucleus and its...Ch. 3.4 - Prob. 3MCCh. 3.4 - Which organelle houses the reactions that extract...Ch. 3.4 - Prob. 5MCCh. 3.4 - Prob. 6MCCh. 3.5 - Prob. 1MCCh. 3.5 - Prob. 2MCCh. 3.5 - Prob. 3MCCh. 3.6 - Prob. 1MCCh. 3.6 - Prob. 2MCCh. 3.6 - Prob. 3MCCh. 3.7 - Prob. 1MCCh. 3.7 - Prob. 2MCCh. 3 - One property that distinguishes cells in domain...Ch. 3 - Prob. 2MCQCh. 3 - Within a single cell, which of the following is...Ch. 3 - Prob. 4MCQCh. 3 - Prob. 5MCQCh. 3 - Prob. 1WIOCh. 3 - Prob. 2WIOCh. 3 - Prob. 3WIOCh. 3 - Rank the following in order from smallest to...Ch. 3 - Which cell in figure 3.31 has the highest ratio of...Ch. 3 - Prob. 6WIOCh. 3 - Prob. 7WIOCh. 3 - Prob. 8WIOCh. 3 - How does the cytoskeleton interact with other...Ch. 3 - Prob. 10WIOCh. 3 - Review the Survey the Landscape figure in the...Ch. 3 - How might you connect the terms proteins and...Ch. 3 - Add the three main components of the cytoskeleton...Ch. 3 - Prob. 4PITCh. 3 - Adel chloroplast, lysosome, and vacuole to this...
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