Biology: The Unity and Diversity of Life (Looseleaf)
15th Edition
ISBN: 9781337408417
Author: STARR
Publisher: CENGAGE L
expand_more
expand_more
format_list_bulleted
Concept explainers
Videos
Textbook Question
Chapter 34, Problem 3DAA
Effect of BPA on Insulin Secretion Bisphenol A (BPA) is an endocrine disruptor that may increase the risk of type 2 diabetes. Angel Nadal suspected that BPA disrupts insulin
FIGURE 34.11 Effects of BPA and DPN on glucose-stimulated insulin secretion. DPN is a chemical known to bind and activate estrogen receptors on pancreatic cells. A glucose concentration of 8 millimolar (mM) is equivalent to that of the blood after a meal.
How were the effects or DPN and BPA similar? How did they differ?
Expert Solution & Answer
Trending nowThis is a popular solution!
Students have asked these similar questions
Describe two features of insulin signaling that affect glucose utilization. Aβ-adrenergic response can be modulated through the actions of a receptorkinase and arrestin because phosphorylation by the kinase desensitizes thereceptor. How might signaling by a tyrosine receptor kinase, such as theinsulin receptor, be modulated?
John was repeating George Palade's pulse and chase experiment to trace insulin secretion pathway within cells. When he observed his
samples under the electron microscope, he saw the ³H]-leucine labelling all over the cells, which indicates that he made some mistakes
in carrying out the experiment. Which of the following is a correct suggestion to improve his result?
O Use liver sample after the pulse-chase injection
O Inject [13C]-leucine instead of [³H]-leucine
Inject non-labeled leucine earlier than what he did
O Use phase contrast light microscope instead of electron microscope
O Observe the sample two days after pulse-chase injection
Bodybuilders use a variety of anabolic substances to gain mass. Two such compounds are insulin and
trenbolone. Insulin has significant anabolic and anti-catabolic properties and impacts the metabolism of
various macromolecules, not just that of carbohydrates. Trenbolone binds the androgen receptor with
an affinity five times higher than that of testosterone and is popular for its fat-burning and anabolic
properties.
H.
Trenbolone
C18H2202
Insulin
C257H383NosO77S6
How do the different targets, mechanisms of action and durations of each drug ultimately lead to the
same desired effect (increase in lean body mass)?
Chapter 34 Solutions
Biology: The Unity and Diversity of Life (Looseleaf)
Ch. 34 - Prob. 1DAACh. 34 - Effect of BPA on Insulin Secretion Bisphenol A...Ch. 34 - Effect of BPA on Insulin Secretion Bisphenol A...Ch. 34 - Effect of BPA on Insulin Secretion Bisphenol A...Ch. 34 - Prob. 1SQCh. 34 - A ________ is synthesized from cholesterol and can...Ch. 34 - Match each pituitary hormone with its target. ____...Ch. 34 - Releasing hormones secreted by the hypothalamus...Ch. 34 - Prob. 5SQCh. 34 - Low blood calcium triggers secretion by ________....
Ch. 34 - _______ lowers blood sugar levels; ________ raises...Ch. 34 - Prob. 8SQCh. 34 - The ________ has both endocrine and exocrine...Ch. 34 - Prob. 10SQCh. 34 - Secretion of _______ suppresses immune responses....Ch. 34 - Prob. 12SQCh. 34 - Which of the following is not a steroid hormone?...Ch. 34 - True or false? All hormones secreted by arthropods...Ch. 34 - Match the term listed at left with the most...Ch. 34 - Women who have been blind since birth almost never...Ch. 34 - A diabetic who injects too much insulin can lose...Ch. 34 - Endocrine disruptors can interfere with biological...Ch. 34 - An arctic hares coat color changes from white to...
Knowledge Booster
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.Similar questions
- In some forms of diabetes, a mutation in the b subunit of the insulin receptor abolishes the enzymatic activity of that subunit. How does the mutation affect the cell’s response to insulin? Can additional insulin (e.g., from injections) overcome the defect?arrow_forwardOverexpression of this receptor in the cells of the adrenal gland causes Cushing's syndrome, a disease caused by the overproduction of cortisol. One strategy that scientists have employed to treat this disease is the use of small molecules that bind to, but do not activate, MC2R. This type of molecule is generically referred to as an antagonist. How can an antagonist bind to the same receptor as ACTH but not activate it? O a. The antagonist can bind covalently while ACTH binds non-covalently O b. The antagonist is only partially complimentary to the binding pocket of MC2R O The antagonist binds to ACTH and blocks it from binding to the receptor properly O d. The antagonist is the exact same structure as ACTH but since it is synthetic it doesn't work One cause of Cushing's syndrome is the inappropriate production of GPCRS in the adrenal gland that are not normally present in those cells. When these receptors are activated they result in the production of cortisol. Which statement about…arrow_forwardBased on your understanding of the binding of insulin, select all of the following events that you would expect to occur in muscle cells due to insulin binding to receptors.Group of answer choices a. Glycogen synthesis is activated b. PFK is stabilized in the R-state and glycolysis is activated c. GLUT4 (transporters) are increased in concentration at the plasma membrane d. Fructose 2,6-bisphosphate increased levels aid in stabilization of the T-state fructose 1,6-bisphosphatase e. Gluconeogenesis is activated in response to elevated fructose 2,6-bisphosphate levels f. Phosphorylation cascades allow for covalent modifications that would aid in the breakdown of glycogen to allow for increased levels of glucose 6-phosphate in the cell g. Hexokinase is inhibited so glucose will not be brought into the cell in high amounts h. Glycogen breakdown pathway is inactivatedarrow_forward
- Describe the process that results in the activation of multiple copies of PKBPKB in response to the binding of a single molecule of insulin to its receptor. Explain why insulin can stimulate the activation PKBPKBof but not the activation of PKPK.arrow_forwardOne such laboratory study investigated the binding of a hormone to three different receptor proteins in the cell membrane. The data collected are shown in the table below 1) Provide a brief explanation as to why ligand binding toproteins must be a reversible process. 2) Calculate the dissociation constant (Kd) for the hormone binding to each of the three proteins.arrow_forwardThyroid hormone is produced within spherical shape structures in the thyroid gland known as 3. 1_ _ _This structure consists of an outer layer of 3.2 epithelial cells and an inner section known-as 3.3___ . This inner section is filled with 3.4 ____ that is synthesised and secreted by-the cells and contains many tyrosine residues. Within this inner section, organification occurs when 3. 5 ____ molecules attach to these tyrosine residues forming either 3. 6____ (with one molecule attacl1ed) or 3. 7____(with two molecules attached). Through coupling, T3 and T4 are also formed. Of these two hormones;- 3. 8 ____is less potent but forms approximately 93% of the metabolically active hormones secreted the thyroid gland.arrow_forward
- Human growth hormone binds to a cell-surface membrane protein that is not a receptor tyrosine kinase. The intracellular domain of the receptor can bind other proteins inside the cell. Furthermore, studies indicate that the receptor is monomeric in the absence of hormone but dimerizes on hormone binding. Propose a possible mechanism for growth-hormone signaling.arrow_forwardSuppose that you had a monoclonal antibody that recognized phosphotyros- ine. How would you expect that antibody to affect insulin signaling?arrow_forwardIn muscle cells, when adrenaline binds to beta-adrenergic receptor, it trigger signaling cascade leading to active glycogen phosphorylate breaks up glycogen into glucose subunits (Glycogen -> G1P). Base on following figure, describe this signaling cascade:arrow_forward
- Assume you have a monoclonal antibody specific for phosphotyrosine. How do you anticipate the antibody affecting insulin signalling?arrow_forwardThe physiological effects of epinephrine should in principle be mimicked by addition of cAMP to the target cells. In practice, addition of cAMP to intact target cells elicits only a minimal physiological response. Why? When the structurally related derivative dibutyryl cAMP (shown below) is added to intact cells, the expected physiological response is readily apparent. Explain the basis for the difference in cellular response to these two substances. Dibutyryl cAMP is widely used in studies of cAMP function.arrow_forwardName two proteins that are effectors of the insulin signaling pathway in adipocytes, liver, or muscle cells. Explain how these effector proteins address the conditions that triggered insulin release.arrow_forward
arrow_back_ios
SEE MORE QUESTIONS
arrow_forward_ios
Recommended textbooks for you
Human Physiology: From Cells to Systems (MindTap ...BiologyISBN:9781285866932Author:Lauralee SherwoodPublisher:Cengage Learning
Human Physiology: From Cells to Systems (MindTap ...
Biology
ISBN:9781285866932
Author:Lauralee Sherwood
Publisher:Cengage Learning
What is cancer? What causes cancer and how is it treated? *UPDATE*; Author: Cancer Treatment Centers of America - CTCA;https://www.youtube.com/watch?v=_N1Sk3aiSCE;License: Standard Youtube License