Pearson eText Human Physiology: An Integrated Approach -- Instant Access (Pearson+)
8th Edition
ISBN: 9780135212905
Author: Dee Silverthorn
Publisher: PEARSON+
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Chapter 3.4, Problem 27CC
Summary Introduction
To determine: Whether plasma or cell is the matrix of blood (connective tissue)
Introduction: the Connective tissues are the tissues which form a connection between different parts of the body. Blood is an important component of the human body. It connects all the parts of the body. It plays an important role in the transportation of materials throughout the body.
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Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug:
(a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate)
(b) Estimate the time for maximum plasma concentration (tmax).
(c) Estimate the maximum plasma concentration (Cmax).
(d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.)
(e)…
Chapter 3 Solutions
Pearson eText Human Physiology: An Integrated Approach -- Instant Access (Pearson+)
Ch. 3.2 - Name three types of lipids found in cell...Ch. 3.2 - Describe three types of membrane proteins and how...Ch. 3.2 - Why do phospholipids in cell membranes form a...Ch. 3.2 - How many phospholipid bilayers will a substance...Ch. 3.3 - Name the three sizes of cytoplasmic protein...Ch. 3.3 - How would the absence of a flagellum affect a...Ch. 3.3 - Prob. 7CCCh. 3.3 - Prob. 8CCCh. 3.3 - What is the function of motor proteins?Ch. 3.3 - What distinguishes organelles from inclusions?
Ch. 3.3 - Prob. 11CCCh. 3.3 - Prob. 12CCCh. 3.3 - Prob. 13CCCh. 3.3 - Prob. 14CCCh. 3.3 - Examining tissue from a previously unknown species...Ch. 3.4 - Prob. 16CCCh. 3.4 - Prob. 17CCCh. 3.4 - Prob. 18CCCh. 3.4 - Prob. 19CCCh. 3.4 - Name two properties that distinguish endocrine...Ch. 3.4 - The basal lamina of epithelium contains the...Ch. 3.4 - You look at a tissue under a microscope and see a...Ch. 3.4 - Prob. 23CCCh. 3.4 - What is the distinguishing characteristic of...Ch. 3.4 - Prob. 25CCCh. 3.4 - Name six types of connective tissues.Ch. 3.4 - Prob. 27CCCh. 3.4 - Why does torn cartilage heal more slowly than a...Ch. 3.5 - Prob. 29CCCh. 3 - Prob. 1RQCh. 3 - In 1972, Singer and Nicolson proposed the fluid...Ch. 3 - Prob. 3RQCh. 3 - Prob. 4RQCh. 3 - Define cytoskeleton. List five functions of the...Ch. 3 - Match each term with the description that fits it...Ch. 3 - Prob. 7RQCh. 3 - Match each organelle with its function:Ch. 3 - Prob. 9RQCh. 3 - Prob. 10RQCh. 3 - List the four major tissue types. Give an example...Ch. 3 - Prob. 12RQCh. 3 - Prob. 13RQCh. 3 - Prob. 14RQCh. 3 - Prob. 15RQCh. 3 - Prob. 16RQCh. 3 - Which would have more rough endoplasmic reticulum:...Ch. 3 - A number of organelles can be considered vesicles....Ch. 3 - Prob. 19RQCh. 3 - Prob. 20RQCh. 3 - Prob. 21RQCh. 3 - Prob. 22RQCh. 3 - Explain how inserting cholesterol into the...Ch. 3 - Prob. 24RQCh. 3 - Prob. 25RQCh. 3 - Prob. 26RQCh. 3 - Prob. 27RQCh. 3 - Prob. 28RQCh. 3 - One result of cigarette smoking is paralysis of...Ch. 3 - Prob. 30RQCh. 3 - Prob. 31RQ
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