Pearson eText Human Physiology: An Integrated Approach -- Instant Access (Pearson+)
8th Edition
ISBN: 9780135212905
Author: Dee Silverthorn
Publisher: PEARSON+
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Chapter 3.4, Problem 20CC
Name two properties that distinguish endocrine glands from exocrine glands.
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Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug:
(a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate)
(b) Estimate the time for maximum plasma concentration (tmax).
(c) Estimate the maximum plasma concentration (Cmax).
(d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.)
(e)…
Chapter 3 Solutions
Pearson eText Human Physiology: An Integrated Approach -- Instant Access (Pearson+)
Ch. 3.2 - Name three types of lipids found in cell...Ch. 3.2 - Describe three types of membrane proteins and how...Ch. 3.2 - Why do phospholipids in cell membranes form a...Ch. 3.2 - How many phospholipid bilayers will a substance...Ch. 3.3 - Name the three sizes of cytoplasmic protein...Ch. 3.3 - How would the absence of a flagellum affect a...Ch. 3.3 - Prob. 7CCCh. 3.3 - Prob. 8CCCh. 3.3 - What is the function of motor proteins?Ch. 3.3 - What distinguishes organelles from inclusions?
Ch. 3.3 - Prob. 11CCCh. 3.3 - Prob. 12CCCh. 3.3 - Prob. 13CCCh. 3.3 - Prob. 14CCCh. 3.3 - Examining tissue from a previously unknown species...Ch. 3.4 - Prob. 16CCCh. 3.4 - Prob. 17CCCh. 3.4 - Prob. 18CCCh. 3.4 - Prob. 19CCCh. 3.4 - Name two properties that distinguish endocrine...Ch. 3.4 - The basal lamina of epithelium contains the...Ch. 3.4 - You look at a tissue under a microscope and see a...Ch. 3.4 - Prob. 23CCCh. 3.4 - What is the distinguishing characteristic of...Ch. 3.4 - Prob. 25CCCh. 3.4 - Name six types of connective tissues.Ch. 3.4 - Prob. 27CCCh. 3.4 - Why does torn cartilage heal more slowly than a...Ch. 3.5 - Prob. 29CCCh. 3 - Prob. 1RQCh. 3 - In 1972, Singer and Nicolson proposed the fluid...Ch. 3 - Prob. 3RQCh. 3 - Prob. 4RQCh. 3 - Define cytoskeleton. List five functions of the...Ch. 3 - Match each term with the description that fits it...Ch. 3 - Prob. 7RQCh. 3 - Match each organelle with its function:Ch. 3 - Prob. 9RQCh. 3 - Prob. 10RQCh. 3 - List the four major tissue types. Give an example...Ch. 3 - Prob. 12RQCh. 3 - Prob. 13RQCh. 3 - Prob. 14RQCh. 3 - Prob. 15RQCh. 3 - Prob. 16RQCh. 3 - Which would have more rough endoplasmic reticulum:...Ch. 3 - A number of organelles can be considered vesicles....Ch. 3 - Prob. 19RQCh. 3 - Prob. 20RQCh. 3 - Prob. 21RQCh. 3 - Prob. 22RQCh. 3 - Explain how inserting cholesterol into the...Ch. 3 - Prob. 24RQCh. 3 - Prob. 25RQCh. 3 - Prob. 26RQCh. 3 - Prob. 27RQCh. 3 - Prob. 28RQCh. 3 - One result of cigarette smoking is paralysis of...Ch. 3 - Prob. 30RQCh. 3 - Prob. 31RQ
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- Select a diet and give a summary of the main components. Do a web search of the diet and choose one link that provides misinformation. Explain why the site itself and/or the information on the site is not credible. This should be a report. This site should be different from U.S News and World Report. For full credit, you must include the following information and elaborate in detail: The diet name The main components of the diet The misinformation website and link What misinformation is being provided in the other website and how did you determine it was not credible?arrow_forward1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple different routes of administration provides greater insight than just a single route of administration alone. The following data was collected in 250 g rats following bolus iv, oral (po), and intraperitoneal (ip) administration.Using this data and set of graphs, determine: (a) k, C0, V, and AUC* for the bolus iv data (b) k, ka, B1, and AUC* for the po data (c) k, ka, B1, and AUC* for the ip data (d) relative bioavailability for po vs ip, Fpo/Fip (e) absolute po bioavailability, (f)Fpo absolute ip bioavailability, Fip MAKE SURE ANSWERS HAVE UNITS if appropriate. SHOW ALL WORK, including equation used, variables used and each step to your solution.arrow_forward2. Drug quantification from plasma is commonly performed by using techniques such as HPLC or LC/MS. However, these methods do have limitations, and investigators may choose to use a radiolabeled analog of a drug instead. Radioligands are molecules that contain radioactive isotopes, commonly 3H or 14C. This technique allows investigators to quantify drug concentration from radiation measurements. The following measurements were made in 250 g rats following oral administration of 18.2 µCi of a 14C-labeled drug of interest: Time (min) Plasma Radiation Levels (µCi/L) 0 0.0 2 9.7 4 19.2 7 25.3 9 37.8 12 39.6 14 45.8 17 48.8 20 52.0 25 56.4 30 59.2 35 60.1 40 61.1 45 62.1 50 62.8 60 63.1 70 62.1 80 60.1 90 57.3 100 55.5 110 53.7 120 52.2 150 48.0 180 45.0 240 39.0 Note that a µCi is a measure of the amount of radioactivity and hence is a measure of the amount of drug present. Given that the oral bioavailability of this drug is known to be essentially 100%, estimate the following from this…arrow_forward
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