To determine: The reason why the host cells evolved a strategy to downregulate innate immunity.
Introduction: The toll-like receptors and or TLRs are the receptors that recognize different patterns of recognition receptors that take place in innate immune responses against the invader or the foreign pathogens. There are a total ten human TLRs.
To determine: The diminution of a pro-inflammatory response by TLR-10 receptor activity.
Introduction: The TLR-10 is known to suppress proinflammatory cytokine production due to some TLR agonists in the mononuclear cell population. The TLR10 also affects the MAPK and Akt signaling pathways, which brings changes in the transcriptome of human monocytes.
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