The occurrence of change in the tertiary or the secondary structure of protein on replacement of one lysine residue by aspartic acid and the mechanism of this replacement. Given: One lysine residue is replaced by an aspartic acid residue in the protein. Introduction: The alteration in the primary structure takes place on replacement of one amino acid with another. The aspartic acid has negative change due to the presence of −COO − (carboxyl group) and the lysine has positive change due to presence of −NH 3 (amino group). Amino acids that were initially bonded to aspartic acid get detached and new amino acids bind to the lysine residues on the replacement of aspartic acid with lysine.

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Chapter 3.2, Problem 1R

Summary Introduction

To review:

The occurrence of change in the tertiary or the secondary structure of protein on replacement of one lysine residue by aspartic acid and the mechanism of this replacement.

Given:

One lysine residue is replaced by an aspartic acid residue in the protein.

Introduction:

The alteration in the primary structure takes place on replacement of one amino acid with another. The aspartic acid has negative change due to the presence of −COO⁻ (carboxyl group) and the lysine has positive change due to presence of −NH₃ (amino group). Amino acids that were initially bonded to aspartic acid get detached and new amino acids bind to the lysine residues on the replacement of aspartic acid with lysine.

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