Chapter 3.2, Problem 2R

Summary Introduction

To review:

The most probable explanation for the observations that replacement of glycine (G) with alanine (A) or serine (S) does not change the shape of a protein, while replacement of G with valine (V) results in the change in the protein’s shape.

Introduction:

A change in the protein shape takes place with even a small change in its amino acid sequence. For example, the glycine resides at a particular location in a protein and makes certain interactions with other amino acids. Replacement of glycine with arginine (R) or glutamic acid (Q) results in a considerable change in the shape of protein near the amino acid change.