Prescott's Microbiology
10th Edition
ISBN: 9781259281594
Author: Joanne Willey, Linda Sherwood Adjunt Professor Lecturer, Christopher J. Woolverton Professor
Publisher: McGraw-Hill Education
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Chapter 31.3, Problem 2.5RIA
Propose two potential functions for mycorrhization helper bacteria.
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1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple different routes of administration provides greater insight than just a single route of administration alone. The following data was collected in 250 g rats following bolus iv, oral (po), and intraperitoneal (ip) administration.Using this data and set of graphs, determine:
(a) k, C0, V, and AUC* for the bolus iv data (b) k, ka, B1, and AUC* for the po data (c) k, ka, B1, and AUC* for the ip data (d) relative bioavailability for po vs ip, Fpo/Fip (e) absolute po bioavailability, (f)Fpo absolute ip bioavailability, Fip
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2. Drug quantification from plasma is commonly performed by using techniques such as HPLC or LC/MS. However, these methods do have limitations, and investigators may choose to use a radiolabeled analog of a drug instead. Radioligands are molecules that contain radioactive isotopes, commonly 3H or 14C. This technique allows investigators to quantify drug concentration from radiation measurements. The following measurements were made in 250 g rats following oral administration of 18.2 µCi of a 14C-labeled drug of interest: Time (min) Plasma Radiation Levels (µCi/L) 0 0.0 2 9.7 4 19.2 7 25.3 9 37.8 12 39.6 14 45.8 17 48.8 20 52.0 25 56.4 30 59.2 35 60.1 40 61.1 45 62.1 50 62.8 60 63.1 70 62.1 80 60.1 90 57.3 100 55.5 110 53.7 120 52.2 150 48.0 180 45.0 240 39.0
Note that a µCi is a measure of the amount of radioactivity and hence is a measure of the amount of drug present. Given that the oral bioavailability of this drug is known to be essentially 100%, estimate the following from this…
The current nutrition labelling regulation in Hong Kong requires food manufacturer to list E+7 information on the package of pre-packaged food products. Do you think that more nutrients, such as calcium and cholesterol, shall be included?
Chapter 31 Solutions
Prescott's Microbiology
Ch. 31.1 - How are filamentous microbes especially well...Ch. 31.1 - Prob. 1RIACh. 31.1 - Prob. 2RIACh. 31.1 - Prob. 3RIACh. 31.1 - What microbes commonly degrade cellulose and...Ch. 31.1 - Which of the following soils would a farmer be...Ch. 31.1 - Why is most nitrogen fertilizer added as ammonium...Ch. 31.2 - What are the differences in preferred soil...Ch. 31.2 - What types of archaea have been detected in soils?Ch. 31.2 - Prob. 3RIA
Ch. 31.3 - Which hyphae are growing saprotrophically in this...Ch. 31.3 - How do you think Frankia spp. protect nitrogenase...Ch. 31.3 - How does the production of opines by the plant...Ch. 31.3 - Define rhizosphere, rhizoplane, and associative...Ch. 31.3 - What unique stresses does a microorganism on a...Ch. 31.3 - List two ways in which compounds produced by...Ch. 31.3 - What important genera are involved in associative...Ch. 31.3 - Prob. 2.1RIACh. 31.3 - Prob. 2.2RIACh. 31.3 - What is the function of the rhizomorph and the...Ch. 31.3 - Describe the uptake and transfer of ammonium by...Ch. 31.3 - Propose two potential functions for mycorrhization...Ch. 31.3 - List several bacteria that are considered...Ch. 31.3 - Prob. 3.2RIACh. 31.3 - What does the term terminally differentiated mean?Ch. 31.3 - How does nitrogen transfer between a rhizobium and...Ch. 31.3 - What is unusual about leghemoglobin production and...Ch. 31.3 - What are the two general mechanisms by which...Ch. 31.3 - What is the difference between the Ti plasmid and...Ch. 31.3 - What functions do the members of the two-component...Ch. 31.3 - What are the two general ways by which plant...Ch. 31.3 - How are plant pathologists attempting to control...Ch. 31.4 - Compare and contrast the metabolism (specifically,...Ch. 31.4 - What happens in terms of microbiological processes...Ch. 31.4 - What microbial genera have been observed in oil...Ch. 31 - Why might vascular plants have developed...Ch. 31 - Prob. 2CHICh. 31 - Prob. 3CHICh. 31 - Prob. 4CHICh. 31 - Prob. 5CHICh. 31 - Prob. 6CHI
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