Anatomy and Physiology
9th Edition
ISBN: 9781260256000
Author: SALADIN
Publisher: MCG
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Chapter 3.1, Problem 1BYGO
What are the base principles of the cell theory?
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1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple different routes of administration provides greater insight than just a single route of administration alone. The following data was collected in 250 g rats following bolus iv, oral (po), and intraperitoneal (ip) administration.Using this data and set of graphs, determine:
(a) k, C0, V, and AUC* for the bolus iv data (b) k, ka, B1, and AUC* for the po data (c) k, ka, B1, and AUC* for the ip data (d) relative bioavailability for po vs ip, Fpo/Fip (e) absolute po bioavailability, (f)Fpo absolute ip bioavailability, Fip
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2. Drug quantification from plasma is commonly performed by using techniques such as HPLC or LC/MS. However, these methods do have limitations, and investigators may choose to use a radiolabeled analog of a drug instead. Radioligands are molecules that contain radioactive isotopes, commonly 3H or 14C. This technique allows investigators to quantify drug concentration from radiation measurements. The following measurements were made in 250 g rats following oral administration of 18.2 µCi of a 14C-labeled drug of interest: Time (min) Plasma Radiation Levels (µCi/L) 0 0.0 2 9.7 4 19.2 7 25.3 9 37.8 12 39.6 14 45.8 17 48.8 20 52.0 25 56.4 30 59.2 35 60.1 40 61.1 45 62.1 50 62.8 60 63.1 70 62.1 80 60.1 90 57.3 100 55.5 110 53.7 120 52.2 150 48.0 180 45.0 240 39.0
Note that a µCi is a measure of the amount of radioactivity and hence is a measure of the amount of drug present. Given that the oral bioavailability of this drug is known to be essentially 100%, estimate the following from this…
The current nutrition labelling regulation in Hong Kong requires food manufacturer to list E+7 information on the package of pre-packaged food products. Do you think that more nutrients, such as calcium and cholesterol, shall be included?
Chapter 3 Solutions
Anatomy and Physiology
Ch. 3.1 - What are the base principles of the cell theory?Ch. 3.1 - What does it mean to say a cell is squamous,...Ch. 3.1 - Why can cells not grow to unlimited size?Ch. 3.1 - What is the difference between cytoplasm and...Ch. 3.1 - Define intracellular fluid (ICF) and extracellular...Ch. 3.1 - Prob. 1AYLOCh. 3.1 - Basic tenets of the cell theoryCh. 3.1 - The nine common cell shapesCh. 3.1 - Prob. 4AYLOCh. 3.1 - Prob. 5AYLO
Ch. 3.1 - Basic structural components of a cellCh. 3.1 - Prob. 7AYLOCh. 3.2 - Prob. 6BYGOCh. 3.2 - Prob. 7BYGOCh. 3.2 - Prob. 8BYGOCh. 3.2 - Prob. 9BYGOCh. 3.2 - Prob. 10BYGOCh. 3.2 - Prob. 11BYGOCh. 3.2 - Prob. 12BYGOCh. 3.2 - The molecules of the plasma membrane and how they...Ch. 3.2 - Prob. 2AYLOCh. 3.2 - Prob. 3AYLOCh. 3.2 - Prob. 4AYLOCh. 3.2 - Prob. 5AYLOCh. 3.2 - Prob. 6AYLOCh. 3.2 - Prob. 7AYLOCh. 3.2 - Prob. 8AYLOCh. 3.2 - Prob. 9AYLOCh. 3.2 - Structure and function of pseudopodsCh. 3.3 - Prob. 13BYGOCh. 3.3 - Prob. 14BYGOCh. 3.3 - Prob. 15BYGOCh. 3.3 - Prob. 16BYGOCh. 3.3 - Prob. 17BYGOCh. 3.3 - Prob. 18BYGOCh. 3.3 - Prob. 19BYGOCh. 3.3 - Prob. 20BYGOCh. 3.3 - Prob. 21BYGOCh. 3.3 - Prob. 1AYLOCh. 3.3 - Prob. 2AYLOCh. 3.3 - Prob. 3AYLOCh. 3.3 - Prob. 4AYLOCh. 3.3 - Prob. 5AYLOCh. 3.3 - Prob. 6AYLOCh. 3.3 - Prob. 7AYLOCh. 3.3 - Prob. 8AYLOCh. 3.3 - Prob. 9AYLOCh. 3.3 - Prob. 10AYLOCh. 3.3 - Prob. 11AYLOCh. 3.3 - Prob. 12AYLOCh. 3.3 - Prob. 13AYLOCh. 3.3 - Prob. 14AYLOCh. 3.3 - Of the preceding mechanisms of transport, which...Ch. 3.4 - Prob. 22BYGOCh. 3.4 - Briefly state how each of the following cell...Ch. 3.4 - Prob. 24BYGOCh. 3.4 - Prob. 25BYGOCh. 3.4 - Prob. 26BYGOCh. 3.4 - Prob. 1AYLOCh. 3.4 - Prob. 2AYLOCh. 3.4 - Prob. 3AYLOCh. 3.4 - Prob. 4AYLOCh. 3.4 - General structure of the endoplasmic reticulum...Ch. 3.4 - Prob. 6AYLOCh. 3.4 - Prob. 7AYLOCh. 3.4 - Prob. 8AYLOCh. 3.4 - Prob. 9AYLOCh. 3.4 - Prob. 10AYLOCh. 3.4 - Structures and functions of centrioles, the...Ch. 3.4 - Prob. 12AYLOCh. 3 - The clear, structureless gel in a cell is its a....Ch. 3 - Prob. 2TYRCh. 3 - Which of the following processes could occur only...Ch. 3 - Prob. 4TYRCh. 3 - Prob. 5TYRCh. 3 - Membrane carriers resemble enzymes except for tie...Ch. 3 - The cotransport of glucose derives energy from a....Ch. 3 - Prob. 8TYRCh. 3 - Most cellular membranes are made by a. the...Ch. 3 - Prob. 10TYRCh. 3 - Prob. 11TYRCh. 3 - Prob. 12TYRCh. 3 - Prob. 13TYRCh. 3 - Prob. 14TYRCh. 3 - Prob. 15TYRCh. 3 - Prob. 16TYRCh. 3 - Prob. 17TYRCh. 3 - Prob. 18TYRCh. 3 - Prob. 19TYRCh. 3 - Prob. 20TYRCh. 3 - Prob. 1BYMVCh. 3 - chromato-Ch. 3 - Prob. 3BYMVCh. 3 - Prob. 4BYMVCh. 3 - Prob. 5BYMVCh. 3 - Prob. 6BYMVCh. 3 - Prob. 7BYMVCh. 3 - Prob. 8BYMVCh. 3 - Prob. 9BYMVCh. 3 - Prob. 10BYMVCh. 3 - Prob. 1WWTSCh. 3 - Prob. 2WWTSCh. 3 - Prob. 3WWTSCh. 3 - Prob. 4WWTSCh. 3 - Prob. 5WWTSCh. 3 - Prob. 6WWTSCh. 3 - Prob. 7WWTSCh. 3 - Prob. 8WWTSCh. 3 - Prob. 9WWTSCh. 3 - Prob. 10WWTSCh. 3 - If someone bought a saltwater fish in a pet shop...Ch. 3 - Prob. 2TYCCh. 3 - Prob. 3TYCCh. 3 - It is often said, even in some textbooks, that...Ch. 3 - Prob. 5TYC
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