Biochemistry
9th Edition
ISBN: 9781319114671
Author: Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher: W. H. Freeman
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Chapter 30, Problem 7P
Interpretation Introduction
Interpretation:
The effect of a mutation that avoids the σ subunit from separating from the RNA polymerase core should be determined.
Concept introduction:
Non-competitive inhibition can be defined as a type of enzyme inhibition. In this inhibition, usually, the inhibitor diminishes the enzyme activity. The inhibitor gets fixed like the normal substrate does to the enzyme. It occurs even if it has been previously bound or not to the substrate. Unlike competitive inhibition, non-competitive inhibition cannot be overcome with the additional substrate.
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