Study Guide with Student Solutions Manual and Problems Book for Garrett/Grisham's Biochemistry, 6th
Study Guide with Student Solutions Manual and Problems Book for Garrett/Grisham's Biochemistry, 6th
6th Edition
ISBN: 9798214167343
Author: GARRETT
Publisher: Cengage Learning US
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Chapter 30, Problem 13P
Interpretation Introduction

Interpretation:

The Shine-Dalgarno sequence and its role in the variation of the efficiency of initiation of the protein synthesis needs to be defined.

Concept Introduction:

Australian scientists Lynn Dalgarno and John Shine proposed the Shine-Dalgarno sequence. Usually situated 8 bases upstream of the initial codon AUG, it is the ribosomal binding site within the mRNA. This sequence is present both within archaea, as well as in bacteria, and exists in some mitochondrial and chloroplastic transcripts. The sequence of RNA supports recruiting the ribosome towards the mRNA to start protein synthesis via aligning the ribosome with the initial codon.

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