Anatomy & Physiology
5th Edition
ISBN: 9780321861580
Author: Marieb, Elaine N.
Publisher: Pearson College Div
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Textbook Question
Chapter 3, Problem 5RQ
Osmosis always involves (a) a selectively permeable membrane, (b) a difference in solvent concentration, (c) diffusion, (d) active transport, (e) a, b, and c.
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1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple different routes of administration provides greater insight than just a single route of administration alone. The following data was collected in 250 g rats following bolus iv, oral (po), and intraperitoneal (ip) administration.Using this data and set of graphs, determine:
(a) k, C0, V, and AUC* for the bolus iv data (b) k, ka, B1, and AUC* for the po data (c) k, ka, B1, and AUC* for the ip data (d) relative bioavailability for po vs ip, Fpo/Fip (e) absolute po bioavailability, (f)Fpo absolute ip bioavailability, Fip
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2. Drug quantification from plasma is commonly performed by using techniques such as HPLC or LC/MS. However, these methods do have limitations, and investigators may choose to use a radiolabeled analog of a drug instead. Radioligands are molecules that contain radioactive isotopes, commonly 3H or 14C. This technique allows investigators to quantify drug concentration from radiation measurements. The following measurements were made in 250 g rats following oral administration of 18.2 µCi of a 14C-labeled drug of interest: Time (min) Plasma Radiation Levels (µCi/L) 0 0.0 2 9.7 4 19.2 7 25.3 9 37.8 12 39.6 14 45.8 17 48.8 20 52.0 25 56.4 30 59.2 35 60.1 40 61.1 45 62.1 50 62.8 60 63.1 70 62.1 80 60.1 90 57.3 100 55.5 110 53.7 120 52.2 150 48.0 180 45.0 240 39.0
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The current nutrition labelling regulation in Hong Kong requires food manufacturer to list E+7 information on the package of pre-packaged food products. Do you think that more nutrients, such as calcium and cholesterol, shall be included?
Chapter 3 Solutions
Anatomy & Physiology
Ch. 3 - Summarize the four key points of the cell theory.Ch. 3 - How would you explain the meaning of a generalized...Ch. 3 - What basic structure do all cellular membranes...Ch. 3 - Why do phospholipids, which form the greater part...Ch. 3 - What is the importance of the glycocalyx in cell...Ch. 3 - Prob. 6CYUCh. 3 - What is the energy source for all types of...Ch. 3 - What determines the direction of any diffusion...Ch. 3 - What are the two types of facilitated diffusion...Ch. 3 - What happens when the Na+-K+ pump is...
Ch. 3 - As a cell grows, its plasma membrane expands. Does...Ch. 3 - Prob. 12CYUCh. 3 - Which vesicular transport process allows a cell to...Ch. 3 - What process establishes the resting membrane...Ch. 3 - Prob. 15CYUCh. 3 - What term is used to indicate signaling chemicals...Ch. 3 - Which organelle is the major site of ATP...Ch. 3 - What are three organelles involved in protein...Ch. 3 - Compare the functions of lysosomes and...Ch. 3 - How are microtubules and microfilaments related...Ch. 3 - Prob. 21CYUCh. 3 - Prob. 22CYUCh. 3 - If a cell ejects or loses its nucleus, what is its...Ch. 3 - What is the role of nucleoli?Ch. 3 - What is the role of nucleoli?Ch. 3 - If one of the DNA strands being replicated reads...Ch. 3 - During what phase of the cell cycle is DNA...Ch. 3 - What are three events occurring in prophase that...Ch. 3 - Codons and anticodons are both three-base...Ch. 3 - How do the A, P, and E ribosomal sites differ...Ch. 3 - What is the role of DNA in transcription?Ch. 3 - What is the importance of ubiquitin in the life of...Ch. 3 - Prob. 33CYUCh. 3 - The smallest unit capable of life by itself is (a)...Ch. 3 - Prob. 2RQCh. 3 - Prob. 3RQCh. 3 - The term used to describe the type of solution in...Ch. 3 - Osmosis always involves (a) a selectively...Ch. 3 - Prob. 6RQCh. 3 - Prob. 7RQCh. 3 - The endocytotic process in which a sampling of...Ch. 3 - Prob. 9RQCh. 3 - The nuclear substance composed of histone proteins...Ch. 3 - The information sequence that determines the...Ch. 3 - Mutations may be caused by (a) X rays, (b) certain...Ch. 3 - The phase of mitosis during which centrioles each...Ch. 3 - Final preparations for cell division are made...Ch. 3 - The RNA synthesized on one of the DNA strands is...Ch. 3 - The RNA species that travels from the nucleus to...Ch. 3 - If DNA has a sequence of AAA, then a segment of...Ch. 3 - A nerve cell and a lymphocyte are presumed to...Ch. 3 - Prob. 19RQCh. 3 - Explain why mitosis can be thought of as cellular...Ch. 3 - Contrast the roles of ER-bound ribosomes with...Ch. 3 - Cells lining the trachea have whiplike motile...Ch. 3 - Name the three phases of interphase and describe...Ch. 3 - Comment on the role of the sodium-potassium pump...Ch. 3 - Differentiate between primary and secondary active...Ch. 3 - Cell division typically yields two daughter cells,...
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