GENETICS:ANALYSIS+PRIN.(LL)-W/ACCESS
6th Edition
ISBN: 9781260239775
Author: BROOKER
Publisher: MCG
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Chapter 3, Problem 4CONQ
With regard to sister chromatids, which phase of mitosis is the organization phase, and which is the separation phase?
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Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug:
(a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate)
(b) Estimate the time for maximum plasma concentration (tmax).
(c) Estimate the maximum plasma concentration (Cmax).
(d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.)
(e)…
Chapter 3 Solutions
GENETICS:ANALYSIS+PRIN.(LL)-W/ACCESS
Ch. 3.1 - 1. Which of the following is not found in a...Ch. 3.1 - When preparing a karyotype, which of the following...Ch. 3.1 - How many sets of chromosomes are found in a human...Ch. 3.2 - Binary fission a. is a form of asexual...Ch. 3.2 - Prob. 2COMQCh. 3.2 - What critical event occurs during the S phase of...Ch. 3.3 - 1. What is the function of the kinetochore during...Ch. 3.3 - Prob. 2COMQCh. 3.4 - Prob. 1COMQCh. 3.4 - Which phase of meiosis is depicted in the drawing...
Ch. 3.5 - In animals, a key difference between...Ch. 3.5 - Which of the following statements regarding plants...Ch. 3.6 - Which of the following is not one of the tenets of...Ch. 3.6 - A pea plant has the genotype TtRr. The independent...Ch. 3.6 - In mammals, sex is determined by a. the SRY gene...Ch. 3.6 - An abnormal fruit fly has two sets of autosomes...Ch. 3 - The process of binary fission begins with a single...Ch. 3 - 2. What is a homolog? With regard to genes and...Ch. 3 - What is a sister chromatid? Are sister chromatids...Ch. 3 - With regard to sister chromatids, which phase of...Ch. 3 - A species is diploid and has three chromosomes per...Ch. 3 - How does the attachment of kinetochore...Ch. 3 - 7. For the following events, specify whether they...Ch. 3 - Prob. 8CONQCh. 3 - A cell is diploid and contains three chromosomes...Ch. 3 - Prob. 10CONQCh. 3 - A eukaryotic cell is diploid and contains 10...Ch. 3 - Prob. 12CONQCh. 3 - 13. A cell has four pairs of chromosomes. Assuming...Ch. 3 - 14. With regard to question C13, how would the...Ch. 3 - Eukaryotic cells must sort their chromosomes...Ch. 3 - Why is it necessary for the chromosomes to...Ch. 3 - Nine-banded armadillos almost always give birth to...Ch. 3 - 18. A diploid species has four chromosomes per set...Ch. 3 - 19. Explain why the products of meiosis may not be...Ch. 3 - The period between meiosis I and meiosis II is...Ch. 3 - 21. List several ways in which telophase appears...Ch. 3 - Corn has 10 chromosomes per set, and the...Ch. 3 - The arctic fox has 50 chromosomes (25 per set),...Ch. 3 - 24. Let’s suppose that a gene affecting...Ch. 3 - 25. Describe the cellular differences between male...Ch. 3 - 26. At puberty, the testes contain a finite number...Ch. 3 - Describe the timing of meiosis I and II during...Ch. 3 - 28. Three genes (A, B, and C) are found on three...Ch. 3 - A woman with an abnormally long chromosome 13 (and...Ch. 3 - Assuming that such a fly would be viable, what...Ch. 3 - 31. What would be the sex of a human with each of...Ch. 3 - When studying living cells in a laboratory,...Ch. 3 - 2. In Morgan’s experiments, which result do you...Ch. 3 - 3. In his original studies of Figure 3.18, Morgan...Ch. 3 - How would you set up crosses to determine if a...Ch. 3 - 5. Occasionally during meiosis, a mistake can...Ch. 3 - Lets suppose that you have made a karyotype of a...Ch. 3 - Prob. 7EQCh. 3 - 8. White-eyed flies have a lower survival rate...Ch. 3 - A rare form of dwarfism that also included hearing...Ch. 3 - 10. Discuss why crosses (i.e., the experiments of...Ch. 3 - Prob. 11EQCh. 3 - 12. Experimentally, how do you think researchers...Ch. 3 - 1. In Figure 3.18, Morgan obtained a white-eyed...Ch. 3 - 3. Discuss the principles of the chromosome theory...
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