Genetics: From Genes To Genomes (6th International Edition)
6th Edition
ISBN: 9781260041217
Author: Leland Hartwell Dr., ? Michael L. Goldberg Professor Dr., ? Janice Fischer, ? Leroy Hood Dr.
Publisher: Mcgraw-Hill
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Question
Chapter 3, Problem 47P
Summary Introduction
a.
To determine:
Whether the description of individuals with spherocytosis represents incomplete penetrance, variable expressivity, or both. Also, whether an individual derive any values from numerical data to measure incomplete penetrance or variable expressivity.
Introduction:
Penetrance refers to the proportion of people with a particular genotype who show the expected
Summary Introduction
b.
To determine:
The treatment for spherocytosis and the way incomplete dominance or variable expressivity would affect the treatment.
Introduction:
The degree or intensity with which a particular genotype is expressed in a phenotype is known as expressivity.
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Several genes in humans in addition to the ABO gene () give rise to recognizable antigens on the surface of the red blood cells. The
Rh marker is determined by positive (R) and negative alleles () of gene R, where R is completely dominant to r. The presence of M and
N surface proteins are controlled by two codominant alleles of gene L (LM and LM. For each mother-child pair, choose the father of
the child from among the males in the right column. (Assume that all mothers and fathers are HH; there is no involvement of the
Bombay phenotype.)
Paternal genotypes maybe used once, more than once, or not at all. Each mother-child pair matches with one or more than one
paternal genotype.
Maternal phenotype:
Child phenotype:
Paternal genotype:
Reset
A, M, Rh(neg)
O, M, Rh(pos)
B, N, Rh(neg)
O, N, Rh(pos)
O, M, Rh(neg)
A, MN, Rh(pos)
A, N, Rh(pos)
AB, MN, Rh(pos)
B, N, Rh(pos)
A, MN, Rh(neg)
Genotypes of
possible fathers
AiLMLN rr
BiLMLN RR
ii LNLN rr
ii LMLM rr
AALMLN RR
The mother of a family with 10 children has blood typeRh+. She also has a very rare condition (elliptocytosis,phenotype E) that causes red blood cells to be oval rather than round in shape but that produces no adverseclinical effects. The father is Rh− (lacks the Rh+ antigen)and has normal red blood cells (phenotype e). The children are 1 Rh+ e, 4 Rh+ E, and 5 Rh− e. Information isavailable on the mother’s parents, who are Rh+ E andRh− e. One of the 10 children (who is Rh+ E) marriessomeone who is Rh+ e, and they have an Rh+ E child.a. Draw the pedigree of this whole family.b. Is the pedigree in agreement with the hypothesisthat the Rh+ allele is dominant and Rh− is recessive?c. What is the mechanism of transmission ofelliptocytosis?d. Could the genes governing the E and Rh phenotypesbe on the same chromosome? If so, estimate the mapdistance between them, and comment on your result
The genotypes below that give viable animals for an
mdm2+/- p53+/- cross are the following (p53 on chr 17 and
mdm2 on chr 12) are:
Chapter 3 Solutions
Genetics: From Genes To Genomes (6th International Edition)
Ch. 3 - For each of the terms in the left column, choose...Ch. 3 - In four-oclocks, the allele for red flowers is...Ch. 3 - The Aa heterozygous snapdragons in Fig. 3.3 are...Ch. 3 - Recall from Chapter 2 Fig. 2.20 that Mendels R...Ch. 3 - In the fruit fly Drosophila melanogaster, very...Ch. 3 - A cross between two plants that both have yellow...Ch. 3 - In radishes, color and shape are each controlled...Ch. 3 - A wild legume with white flowers and long pods is...Ch. 3 - Assuming no involvement of the Bombay phenotype in...Ch. 3 - Several genes in humans in addition to the ABO...
Ch. 3 - Alleles of the gene that determines seed coat...Ch. 3 - One of your fellow students tells you that there...Ch. 3 - In a population of rabbits, you find three...Ch. 3 - In clover plants, the pattern on the leaves is...Ch. 3 - Fruit flies with one allele for curly wings Cy and...Ch. 3 - In certain plant species such as tomatoes and...Ch. 3 - In a species of tropical fish, a colorful orange...Ch. 3 - People heterozygous for normal and nonfunctional...Ch. 3 - Using old Fugate family Bibles and the Perry...Ch. 3 - A rooster with a particular comb morphology called...Ch. 3 - A black mare was crossed to a chestnut stallion...Ch. 3 - Filled-in symbols in the pedigree that follows...Ch. 3 - You perform a cross between two true-breeding...Ch. 3 - a. How would you describe inheritance of flower...Ch. 3 - Suppose the intermediate called Colorless...Ch. 3 - Explain the difference between epistasis and...Ch. 3 - The dominant allele H reduces the number of body...Ch. 3 - Secretors genotypes SS and Ss secrete their A and...Ch. 3 - Normally, wild violets have yellow petals with...Ch. 3 - A woman who is blood type B has a child whose...Ch. 3 - The following table shows the responses of blood...Ch. 3 - Three different pure-breeding strains of corn that...Ch. 3 - In mice, the AY allele of the agouti gene is a...Ch. 3 - A student whose hobby was fishing pulled a very...Ch. 3 - Suppose that blue flower color in a plant species...Ch. 3 - This problem examines possible biochemical...Ch. 3 - Considering your answers to Problem 36, does the...Ch. 3 - You picked up two mice one female and one male...Ch. 3 - Figure 3.21 and Fig. 3.28b both show traits that...Ch. 3 - Three genes in fruit flies affect a particular...Ch. 3 - The garden flower Salpiglossis sinuata painted...Ch. 3 - In foxgloves, three different petal phenotypes...Ch. 3 - In a culture of fruit flies, matings between any...Ch. 3 - Prob. 44PCh. 3 - A couple wants to know the probability that their...Ch. 3 - This problem illustrates why classical geneticists...Ch. 3 - Prob. 47PCh. 3 - Familial hypercholesterolemia FH is an inherited...Ch. 3 - You have come into contact with two unrelated...Ch. 3 - Polycystic kidney disease is a dominant trait that...Ch. 3 - Identical monozygotic twins have similar, but not...Ch. 3 - Using each of the seven coat color genes discussed...
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