Human Anatomy
9th Edition
ISBN: 9780135168059
Author: Marieb, Elaine Nicpon, Brady, Patricia, Mallatt, Jon
Publisher: Pearson Education, Inc.,
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Chapter 3, Problem 3CRCAQ
Your cat finds a large ball of string and starts eating it unbeknownst to you. When you discover him, he has string extending from both his mouth and his anus. What primary germ layer (s) is the string in contact with as it passes through the cat?
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Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug:
(a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate)
(b) Estimate the time for maximum plasma concentration (tmax).
(c) Estimate the maximum plasma concentration (Cmax).
(d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.)
(e)…
Chapter 3 Solutions
Human Anatomy
Ch. 3 - Dining which prenatal period is the basic body...Ch. 3 - Which abdominal structures form from the inner...Ch. 3 - Using directional terms (Table 1.1), describe the...Ch. 3 - Describe gastrulation. During which week of...Ch. 3 - What structure induces the formation of the neural...Ch. 3 - Which type or types of mesoderm Cluster into...Ch. 3 - After folding takes place, which embryonic germ...Ch. 3 - Does endoderm form the inner Iining of the inner...Ch. 3 - Which part of the somite forms the vertebrae and...Ch. 3 - What does the splanchnic lateral plate mesoderm...
Ch. 3 - A birth defect in the heart is caused by a...Ch. 3 - Why is respiratory distress common in babies born...Ch. 3 - 1ndicate whether each of the following relates to...Ch. 3 - The outer layer of the blastocyst, which attaches...Ch. 3 - Most birth defects can be traced to disruption of...Ch. 3 - The primary germ layer that forms the trunk...Ch. 3 - Each embryonic structure in column B with its...Ch. 3 - Match each date in column B [approximate time...Ch. 3 - It is currently possible to save some premature...Ch. 3 - Somites are evidence of (a) a structure from...Ch. 3 - Which of the following embryonic structures are...Ch. 3 - Prob. 10RQCh. 3 - When it is 1.5 months old, an average embryo is...Ch. 3 - Gastrulation is the (a) formation of three germ...Ch. 3 - The epiblast forms (a) only the ectoderm, (b) the...Ch. 3 - The limbs develop during the (a) start of the...Ch. 3 - The notochord develops primarily from (a)...Ch. 3 - The fetal period is (a) the �rst 8 weeks of...Ch. 3 - What important event occurs at the primitive...Ch. 3 - What is the function of the amniotic sac and the...Ch. 3 - (a) What is mesenchyme? (b) How does it differ...Ch. 3 - Explain how the flat embryonic disc takes on the...Ch. 3 - In anatomy lab, Thaya pointed to the vertebrae of...Ch. 3 - Neural crest is the one embryonic tissue that is...Ch. 3 - Many embryonic events �rst occur cranially, then...Ch. 3 - Prob. 24RQCh. 3 - Differentiate the outer tube from the inner tube....Ch. 3 - Before Delta studied embryology in her anatomy...Ch. 3 - A friend in your dormitory, a freshman, tells you...Ch. 3 - Insufficient folic acid in the early weeks of...Ch. 3 - Your cat finds a large ball of string and starts...Ch. 3 - When is the earliest time the sex of a fetus can...
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