Essentials of Human Anatomy & Physiology (12th Edition)
12th Edition
ISBN: 9780134395326
Author: Elaine N. Marieb, Suzanne M. Keller
Publisher: PEARSON
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Chapter 3, Problem 33SAE
How does tissue healing by fibrosis differ from healing by regeneration? Which is more desirable and why?
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1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple different routes of administration provides greater insight than just a single route of administration alone. The following data was collected in 250 g rats following bolus iv, oral (po), and intraperitoneal (ip) administration.Using this data and set of graphs, determine:
(a) k, C0, V, and AUC* for the bolus iv data (b) k, ka, B1, and AUC* for the po data (c) k, ka, B1, and AUC* for the ip data (d) relative bioavailability for po vs ip, Fpo/Fip (e) absolute po bioavailability, (f)Fpo absolute ip bioavailability, Fip
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2. Drug quantification from plasma is commonly performed by using techniques such as HPLC or LC/MS. However, these methods do have limitations, and investigators may choose to use a radiolabeled analog of a drug instead. Radioligands are molecules that contain radioactive isotopes, commonly 3H or 14C. This technique allows investigators to quantify drug concentration from radiation measurements. The following measurements were made in 250 g rats following oral administration of 18.2 µCi of a 14C-labeled drug of interest: Time (min) Plasma Radiation Levels (µCi/L) 0 0.0 2 9.7 4 19.2 7 25.3 9 37.8 12 39.6 14 45.8 17 48.8 20 52.0 25 56.4 30 59.2 35 60.1 40 61.1 45 62.1 50 62.8 60 63.1 70 62.1 80 60.1 90 57.3 100 55.5 110 53.7 120 52.2 150 48.0 180 45.0 240 39.0
Note that a µCi is a measure of the amount of radioactivity and hence is a measure of the amount of drug present. Given that the oral bioavailability of this drug is known to be essentially 100%, estimate the following from this…
The current nutrition labelling regulation in Hong Kong requires food manufacturer to list E+7 information on the package of pre-packaged food products. Do you think that more nutrients, such as calcium and cholesterol, shall be included?
Chapter 3 Solutions
Essentials of Human Anatomy & Physiology (12th Edition)
Ch. 3 - 1. Which of the following would you expect to find...Ch. 3 - Adult cell types you might expect to have gap...Ch. 3 - Which of the following are possible functions of...Ch. 3 - 4. A cell with abundant peroxisomes would most...Ch. 3 - A cell stimulated to increase its steroid...Ch. 3 - For diffusion to occur, there must be a. a...Ch. 3 - In which of the following tissue types might you...Ch. 3 - Which epithelium is “built” to withstand friction?...Ch. 3 - 9. What kind of connective tissue acts as a...Ch. 3 - What type of connective tissue prevents muscles...
Ch. 3 - Which of the following terms describe cardiac...Ch. 3 - Cancer is the same as a. all tumors. b. al...Ch. 3 - Prob. 13SAECh. 3 - 14. Although cells have differences that reflect...Ch. 3 - Describe the special function of DNA found in the...Ch. 3 - 16. Describe the four structural components of the...Ch. 3 - Prob. 17SAECh. 3 - 18. What two structural characteristics of cell...Ch. 3 - Explain the effect of the following solutions on...Ch. 3 - Prob. 20SAECh. 3 - Define mitosis. Why is mitosis important?Ch. 3 - Prob. 22SAECh. 3 - Prob. 23SAECh. 3 - 24. Why can an organ be permanently damaged if its...Ch. 3 - Describe the relative roles of DNA and RNA in...Ch. 3 - Define tissue. List the four major types of...Ch. 3 - Describe the general characteristics of epithelial...Ch. 3 - 28. Where is ciliated epithelium found, and what...Ch. 3 - What are the general structural characteristics of...Ch. 3 - Name a connective tissue with (1) a soft fluid...Ch. 3 - Prob. 31SAECh. 3 - 32. Tell where each of the three types of muscle...Ch. 3 - 33. How does tissue healing by fibrosis differ...Ch. 3 - Prob. 34SAECh. 3 - Prob. 35SAECh. 3 - Two examples of chemotherapeutic drugs (used to...Ch. 3 - Hydrocortisone is an anti-inflammatory drug that...Ch. 3 - John has severely injured his knee during football...Ch. 3 - 39. Three patients in an intensive care unit are...Ch. 3 - 40. Michael had a nervous habit of chewing on the...Ch. 3 - 41. Think carefully about the chemistry of the...Ch. 3 - 42. Jeanie was taken to the ER for heat stroke and...
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