Microbiology with Diseases by Body System & Modified MasteringMicrobiology with Pearson eText -- ValuePack Access Card -- for Microbiology with Diseases by Body System Package
1st Edition
ISBN: 9780133857122
Author: Robert W. Bauman Ph.D.
Publisher: PEARSON
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Chapter 3, Problem 2VI
Label each type of flagellar arrangement.
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Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug:
(a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate)
(b) Estimate the time for maximum plasma concentration (tmax).
(c) Estimate the maximum plasma concentration (Cmax).
(d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.)
(e)…
Chapter 3 Solutions
Microbiology with Diseases by Body System & Modified MasteringMicrobiology with Pearson eText -- ValuePack Access Card -- for Microbiology with Diseases by Body System Package
Ch. 3 - Prob. 1TMWCh. 3 - In 1985, an Israeli scientist discovered the...Ch. 3 - Why is a pilus a type of fimbria, but a flagellum...Ch. 3 - Why is the microbe illustrated in Figure 3.2 more...Ch. 3 - When the bacterium Escherichia coli is grown in a...Ch. 3 - Prob. 6TMWCh. 3 - Why do scientists consider bacterial and archaeal...Ch. 3 - Why did scientists in the 19th and early 20th...Ch. 3 - Why do some scientists consider archaea, which are...Ch. 3 - Why are eukaryotic glycocalyces covalently bound...
Ch. 3 - Many antimicrobial drugs target bacterial cell...Ch. 3 - Colchicine is a drug that inhibits microtubule...Ch. 3 - A cell may allow a large or charged chemical to...Ch. 3 - Which of the following statements concerning...Ch. 3 - A 9 + 2 arrangement of microtubules is seen in...Ch. 3 - Which of the following is most associated with...Ch. 3 - Which of the following is not associated with...Ch. 3 - Which of the following is true of Svedbergs? a....Ch. 3 - Which of the following statements is true? a. The...Ch. 3 - Prob. 8MCCh. 3 - Bacterial flagella are ______________. a. anchored...Ch. 3 - Prob. 10MCCh. 3 - A Gram-negative cell is moving uric acid across...Ch. 3 - Gram-positive bacteria _______________. a. have a...Ch. 3 - Endospores ________________. a. are reproductive...Ch. 3 - Prob. 14MCCh. 3 - Dipicolinic acid is an important component of...Ch. 3 - Match the structures on the left with the...Ch. 3 - Match the term on the left with its description on...Ch. 3 - Label the structures of the following prokaryotic...Ch. 3 - Label each type of flagellar arrangement.Ch. 3 - A scientist who is studying passive movement of...Ch. 3 - Describe (or draw) an example of diffusion down a...Ch. 3 - Sketch, name, and describe three flagellar...Ch. 3 - Prob. 3SACh. 3 - The term fluid mosaic has been used in describing...Ch. 3 - A local newspaper writer has contacted you, an...Ch. 3 - Prob. 6SACh. 3 - Compare bacterial cells and algal cells, giving at...Ch. 3 - Contrast a cell of Streptococcus pyogenes (a...Ch. 3 - Differentiate among pili, fimbriae, and cilia,...Ch. 3 - Prob. 10SACh. 3 - Prob. 11SACh. 3 - Prob. 12SACh. 3 - What is the function of glycocalyces and fimbriae...Ch. 3 - Prob. 14SACh. 3 - Compare and contrast three types of passive...Ch. 3 - Prob. 16SACh. 3 - Prob. 17SACh. 3 - Prob. 18SACh. 3 - Prob. 1CTCh. 3 - Methylene blue binds to DNA. What structures in a...Ch. 3 - Prob. 3CTCh. 3 - Prob. 4CTCh. 3 - A researcher carefully inserts an electrode into...Ch. 3 - Prob. 6CTCh. 3 - An electron micrograph of a newly discovered cell...Ch. 3 - An entry in a recent scientific journal reports...Ch. 3 - Prob. 9CTCh. 3 - Prob. 10CTCh. 3 - Prob. 11CTCh. 3 - Prob. 12CTCh. 3 - Prob. 13CTCh. 3 - Prob. 14CTCh. 3 - Using the following terms, fill in the following...
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- Select a diet and give a summary of the main components. Do a web search of the diet and choose one link that provides misinformation. Explain why the site itself and/or the information on the site is not credible. This should be a report. This site should be different from U.S News and World Report. For full credit, you must include the following information and elaborate in detail: The diet name The main components of the diet The misinformation website and link What misinformation is being provided in the other website and how did you determine it was not credible?arrow_forward1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple different routes of administration provides greater insight than just a single route of administration alone. The following data was collected in 250 g rats following bolus iv, oral (po), and intraperitoneal (ip) administration.Using this data and set of graphs, determine: (a) k, C0, V, and AUC* for the bolus iv data (b) k, ka, B1, and AUC* for the po data (c) k, ka, B1, and AUC* for the ip data (d) relative bioavailability for po vs ip, Fpo/Fip (e) absolute po bioavailability, (f)Fpo absolute ip bioavailability, Fip MAKE SURE ANSWERS HAVE UNITS if appropriate. SHOW ALL WORK, including equation used, variables used and each step to your solution.arrow_forward2. Drug quantification from plasma is commonly performed by using techniques such as HPLC or LC/MS. However, these methods do have limitations, and investigators may choose to use a radiolabeled analog of a drug instead. Radioligands are molecules that contain radioactive isotopes, commonly 3H or 14C. This technique allows investigators to quantify drug concentration from radiation measurements. The following measurements were made in 250 g rats following oral administration of 18.2 µCi of a 14C-labeled drug of interest: Time (min) Plasma Radiation Levels (µCi/L) 0 0.0 2 9.7 4 19.2 7 25.3 9 37.8 12 39.6 14 45.8 17 48.8 20 52.0 25 56.4 30 59.2 35 60.1 40 61.1 45 62.1 50 62.8 60 63.1 70 62.1 80 60.1 90 57.3 100 55.5 110 53.7 120 52.2 150 48.0 180 45.0 240 39.0 Note that a µCi is a measure of the amount of radioactivity and hence is a measure of the amount of drug present. Given that the oral bioavailability of this drug is known to be essentially 100%, estimate the following from this…arrow_forward
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