GENETIC ANALYSIS: AN INTEG. APP. W/MAS
2nd Edition
ISBN: 9781323142790
Author: Sanders
Publisher: Pearson Custom Publishing
expand_more
expand_more
format_list_bulleted
Concept explainers
Textbook Question
Chapter 3, Problem 25P
Lesch–Nyhan syndrome (OMIM 300322) is a rare X-linked recessive disorder that produces severe mental retardation, spastic cerebral palsy, and self-mutilation.
a. What is the probability that the first son of a woman whose brother has Lesch–Nyhan syndrome will be affected?
b. If the first son of the woman described in (a) is affected, what is the probability that her second son is affected?
c. What is the probability that the first son of a man whose brother has Lesch–Nyhan syndrome will be affected?
Expert Solution & Answer
Want to see the full answer?
Check out a sample textbook solutionStudents have asked these similar questions
I will be adding two questions here because I asked two of the same questions twice by accident earlier.
A man and a woman do not have hemophilioa, but the womans father did. (Hemophilia is X-linked recessive).
a) What is the probability that they will have a child with hemophilia?
b) Is it possible for any of their daughters to be affected? Explain.
A cross between a horse homozygous for red hair and a horse homozygous for white hair results in offspring with the coat colour called roan. When you look at the fur of the roan offspring you see both red and white hairs. What type of inheritance best explains this?
a) blending inheritance
b)codominance
c)incomplete codominance
d)multiple alleles
O.
2
Hemophilia A is an X-linked trait where blood clotting is affected due to a mutation in a clotting
factor protein. Georgio has hemophilia and attends a support group where he meets Gbenga, who
does not have the disease, but whose father has hemophilia. Her mother is not affected.
A) If they marry, what percentage % of all their children will have hemophilia?
%
B) Georgio meets another woman, Maria, at the hemophilia support group. Maria also lacks the
trait, but her mother has hemophilia while her father is unaffected.
#
3
Would a Georgio-Maria mating provide a larger chance of having afflicted children compared to a
Georgio-Gbenga mating?
C) Show how you came up with your answer to B.
Edit View Insert Format Tools Table
12pt ✓
80
F3
V
Paragraph ✓
$
4
Yes or No
000
000
F4
DO LO
%
5
BIUAV T² |
F5
^
MacBook Air
6
2
F6
V
&
7
F7
*
8
DII
F8
(
9
DD
F9
1
0
S
F
Anhidrotic ectodermal dysplasia is an X-linked recessive disorder in humans characterized by small teeth, no sweat glands, and sparse body hair. This trait is usually seen in men, but women who are heterozygous carriers of the trait often have irregular patches of skin with few or no sweat glands (see the illustration below). a. Explain why women who are heterozygous carriers of a recessive gene for anhidrotic ectodermal dysplasia have irregular patches of skin lacking sweat glands. b. Why does the distribution of the patches of skin lacking sweat glands differ among the females depicted in the illustration, even between the identical twins?
Chapter 3 Solutions
GENETIC ANALYSIS: AN INTEG. APP. W/MAS
Ch. 3 - Examine the following diagrams of cells from an...Ch. 3 - Our closest primate relative, the chimpanzee, has...Ch. 3 -
3. In a test of his chromosome theory of...Ch. 3 - Cohesion between sister chromatids, as well as...Ch. 3 - 5. The diploid number of the hypothetical animal...Ch. 3 - 6. An organism has alleles R1 and R2 on one pair...Ch. 3 - Explain how the behavior of homologous chromosomes...Ch. 3 - 8. Suppose crossover occurs between the homologous...Ch. 3 -
9. Alleles A and a are on one pair of autosomes,...Ch. 3 - Prob. 10P
Ch. 3 - Describe the role of the following structures or...Ch. 3 - A womans father has ornithine transcarbamylase...Ch. 3 - In humans, hemophilia A (OMIM 306700) is an...Ch. 3 -
14. A wild-type male and a wild-type female...Ch. 3 - 15. A woman with severe discoloration of her tooth...Ch. 3 - 16. In a large metropolitan hospital, cells from...Ch. 3 - In cats, tortoiseshell coat color appears in...Ch. 3 - 18. The gene causing Coffin–Lowry syndrome (OMIM...Ch. 3 - 19. Four eye-color mutants in Drosophila—apricot,...Ch. 3 - 20. For each pedigree shown,
a. Identify which...Ch. 3 - 21. Use the blank pedigrees provided to depict...Ch. 3 - 22. Figure 3.22 (page 89) illustrates reciprocal...Ch. 3 - 23. In fruit flies, yellow body (y) is recessive...Ch. 3 - 24. In a species of fish, a black spot on the...Ch. 3 - LeschNyhan syndrome (OMIM 300322) is a rare...Ch. 3 - 26. In humans, SRY is located near a...Ch. 3 - 27. In an 1889 book titled Natural Inheritance...Ch. 3 - 30. Drosophila has a diploid chromosome number of...Ch. 3 - 29. A wild-type Drosophila male and female are...Ch. 3 - 28. In Drosophila, the X-linked echinus eye...Ch. 3 - 31. While examining a young tortoiseshell cat, you...Ch. 3 - 32. Redgreen color blindness in humans is...
Knowledge Booster
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.Similar questions
- Given the karyotype shown at right, is this a male or a female? Normal or abnormal? What would the phenotype of this individual be?arrow_forwardA mother is heterozygous for the X-linked gene for colorblindness and also heterozygous for the autosomal inherited sickle cell anemia. She is married to a man who can see color normally and who is heterozygous for sickle cell trait. Using b (colorblind), B (normal color), S (normal hemoglobin), s (sickle cell), answer the following: a. What are the genotypes of the parents? b: What is the probability of having a child who is both color blind and has sickle cell anemia?arrow_forwardvarrow_forward
- Please answer both questions in detail. Correct answers are highlighted.arrow_forwardSickle cell anemia is an inherited red blood cell disorder in which there are not enough healthy red blood cells to carry oxygen throughout the body. The allele that causes sickle-cell anemia is autosomal recessive (s), and the dominant allele can be represented by S. How many offspring will be affected by the disorder if the mother is a carrier, and the father appears to be normal? (Include the gender) a. b. How many will become carriers? (include the gender) A- 三三三 四 四 II !!arrow_forwardThe pedigree below represents a family in which some members (shaded) have a monogenic genetic disease. Assume it is fully penetrant. 4999 a. If the disease were X-linked recessive, what would be the probability that a male child born to II- 3 and II-4 will be affected? Why? (Note: we already know the child is male.) b. If the disease were autosomal dominant what would be the probability that a male child born to II-3 and II-4 will be affected? Why? (Note: we already know the child is male.)arrow_forward
- a. The pedigree follows the inheritance of a relatively common trait. Is the trait most likely autosomal dominant, autosomal recessive, X-linked dominant, or X-linked recessive? Explain your reasoning. b. If the couple marked with a “*” had another child, what is the probability that it would be an affected daughter? (Note: this is a compound outcome.)arrow_forward152 Phenylketonuria (PKU) is a disorder caused by a recessive allele. Two carrier individuals have progeny. Answer the following questions in order and show solutions whenever relevant. If they have a normal child, what is the probability that he or she will be heterozygous? If they have three children, what is the probability of having 2 affected children and one normal child?arrow_forwardX-linked ichthyosis is an X-linked recessive trait that manifests in part as dry, scaly skin (“ichthy-” = fish or fish like). Suppose a couple are considering having a child together. Parent A is heterozygous for the ichthyosis allele while Parent B is hemizygous negative for the ichthyosis allele. What is the probability their child would be unafflicted with ichthyosis but be a carrier of the ichthyosis-causing allele? a.0% b.25% c.50% d.75% e.100%arrow_forward
- Consider a couple: a woman who is homozygous for a recessive mutation that causes X-linked colorblindness, and a man with full color vision (he does not carry a copy of the mutation). a) What is the probability that a son of this couple will be colorblind? b) What is the probability that a daughter of the couple will be colorblind?arrow_forwardIn 1995, doctors reported a Chinese family in whichretinitis pigmentosa (progressive degeneration of theretina leading to blindness) affected only males. Allsix sons of affected males were affected, but all of thefive daughters of affected males (and all of thechildren of these daughters) were unaffected.a. What is the likelihood that this form of retinitispigmentosa is due to an autosomal mutationshowing complete dominance?b. What other possibilities could explain the inheritance of retinitis pigmentosa in this family? Whichof these possibilities do you think is most likely?arrow_forwardGlucose-6-phosphate dehydrogenase deficiency (G6PD) is inherited as a recessive allele of an X-linked gene in humans. A woman whose father suffered from G6PD marries a normal man.(a) What proportion of their sons is expected to be G6PD?(b) If the husband was not normal but was G6PD deficient, would you change your answer in part (a)arrow_forward
arrow_back_ios
SEE MORE QUESTIONS
arrow_forward_ios
Recommended textbooks for you
- Human Heredity: Principles and Issues (MindTap Co...BiologyISBN:9781305251052Author:Michael CummingsPublisher:Cengage LearningBiology Today and Tomorrow without Physiology (Mi...BiologyISBN:9781305117396Author:Cecie Starr, Christine Evers, Lisa StarrPublisher:Cengage Learning
Human Heredity: Principles and Issues (MindTap Co...
Biology
ISBN:9781305251052
Author:Michael Cummings
Publisher:Cengage Learning
Biology Today and Tomorrow without Physiology (Mi...
Biology
ISBN:9781305117396
Author:Cecie Starr, Christine Evers, Lisa Starr
Publisher:Cengage Learning
How stress affects your body - Sharon Horesh Bergquist; Author: TED-Ed;https://www.youtube.com/watch?v=v-t1Z5-oPtU;License: Standard Youtube License