EP CONNECT ONLINE ACCESS FOR BIOLOGY:
5th Edition
ISBN: 9781260542226
Author: Hoefnagels
Publisher: MCGRAW-HILL HIGHER EDUCATION
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Chapter 29, Problem 3MCQ
Summary Introduction
Introduction:
Bone consists of a network of blood vessels and nerve fibers. The end of the bone consists of the spongy tissue with cartilage fibers. This cartilage tissue contains of a layer of collagen. There is a concentric ring of cells surrounded by a fluid in the bone consisting of the osteocyte cells. The outer bone consists of a rigid layer of cells called as the compact bone.
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Digoxin: Intravenous Bolus - Two Compartment Model
Drug
Digoxin
Route:
IV Bolus
Dose:
0.750 mg
Plasma Concentration Time Profile
Beta
Alpha
Time (hrs)
Conc (ng/ml)
LN
(ng/ml)
LN
(ng/ml)
LN
0.00
#NUM!
#NUM!
#NUM!
0.10
12.290
2.509
#NUM!
#NUMI
0.60
6.975
1.942
#NUM!
#NUMI
1.00
4.649
1.537
#NUM!
#NUMI
2.00
2.201
0.789
#NUM!
#NUM!
3.00
1.536
0.429
#NUM!
#NUM!
4.00
1.342
0.294
#NUM!
#NUM!
5.00
1.273
0.241
#NUM!
#NUMI
6.00
1.238
0.213
#NUM!
#NUM!
7.00
1.212
0.192
#NUM!
#NUM!
8.00
1.188
0.172
#NUMI
#NUM!
9.00
1.165
0.153
#NUM!
#NUMI
10.00
1.143
0.134
#NUMI
#NUM!
11.00
1.122
0.115
#NUM!
12.00
1.101
0.096
#NUMI
13.00
1.080
0.077
#NUMI
16.00
1.020
0.020
#NUMI
24.00
0.876
-0.132
#NUMI
Pharmacokinetic Parameters
Parameter
Value
Alpha
B
Beta
Units
ng/ml
hr-1
ng/ml
hr-1
CO
ng/ml
H.C
AUC
ng x hr/ml
Vc
Vbeta
Vss
C
L/hr
TK (alpha)
hr
TX (beta)
days
5+
F3
F4
F5
0+
F6
F7
%
6
95
14
#3
29
&
t
F8
F9
FW
EW
Linuron, a derivative of urea, is used as an herbicide. Linuron serum levels were measured in 4Kg
rabbits following a bolus IV injection of 10mg/kg.
Time (minutes)
Serum Linuron Levels (ug/ml)
following IV dose
10
15.48
20
8.60
30
5.90
45
3.78
60
2.42
90
1.49
120
0.93
180
0.60
240
0.41
300
0.29
360
0.22
Analyze this data and perform the necessary calculations to determine the following pharmacokinetic
parameters from the IV data: (5 points per parameter, 24 parameters/variables ■ 120 points
possible). You do NOT need to submit graphs or data tables.
Give the terminal regression line equation and R or R² value:
Give the x axis (name and units, if any) of the terminal line:
Give the y axis (name and units, if any) of the terminal line:
Give the residual regression line equation and R or R² value:
Give the x axis (name and units, if any) of the residual line:
Give the y axis (name and units, if any) of the residual line:
Chapter 29 Solutions
EP CONNECT ONLINE ACCESS FOR BIOLOGY:
Ch. 29.1 - How do the skeletal and muscular systems interact?Ch. 29.1 - Prob. 2MCCh. 29.2 - What are the components of the axial and...Ch. 29.2 - Prob. 2MCCh. 29.3 - Prob. 1MCCh. 29.3 - What are the differences between spongy bone and...Ch. 29.3 - Prob. 3MCCh. 29.3 - Prob. 4MCCh. 29.3 - Prob. 5MCCh. 29.4 - Prob. 1MC
Ch. 29.4 - Prob. 2MCCh. 29.4 - How do ATP, motor neurons, and calcium ions...Ch. 29.5 - Prob. 1MCCh. 29.5 - Prob. 2MCCh. 29.6 - Prob. 1MCCh. 29.6 - Prob. 2MCCh. 29.6 - Prob. 3MCCh. 29.7 - Prob. 1MCCh. 29.7 - Prob. 2MCCh. 29 - Prob. 1MCQCh. 29 - The axial skeleton is to the appendicular skeleton...Ch. 29 - Prob. 3MCQCh. 29 - Prob. 4MCQCh. 29 - Prob. 5MCQCh. 29 - Prob. 6MCQCh. 29 - Prob. 1WIOCh. 29 - Prob. 2WIOCh. 29 - Prob. 3WIOCh. 29 - Prob. 4WIOCh. 29 - Prob. 5WIOCh. 29 - Prob. 6WIOCh. 29 - Describe four muscle proteins and their functions.Ch. 29 - Prob. 8WIOCh. 29 - Prob. 9WIOCh. 29 - Prob. 10WIOCh. 29 - Write the sequence of events that leads to a...Ch. 29 - Prob. 12WIOCh. 29 - Refer to figure 29.24 and the chapter content to...Ch. 29 - 3. Add exercise to the concept map in at least...
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