BIOLOGY-CONCEPTS+APP.CHAP 1-15>CUSTOM<
17th Edition
ISBN: 9781337450607
Author: STARR
Publisher: CENGAGE LEARNING (CUSTOM)
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Chapter 29, Problem 2CT
Summary Introduction
To determine:
The neurotransmitter whose release is interfered by Botox.
Introduction:
Botox is a neurotoxin produced by the bacterium Clostridium botulinum that causes severe food poisoning. Botox is used for cosmetic purposes for the treatment of facial wrinkles. It is also used to treat muscle spasms, excessive sweating, and migraine.
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The following table is from Kumar et. al. Highly Selective Dopamine D3 Receptor (DR) Antagonists and Partial Agonists Based on Eticlopride and the D3R Crystal Structure: New Leads for Opioid Dependence Treatment. J. Med Chem 2016.
The following figure is from Caterina et al. The capsaicin receptor: a heat activated ion channel in the
pain pathway. Nature, 1997. Black boxes indicate capsaicin, white circles indicate resinferatoxin.
You are a chef in a fancy new science-themed restaurant. You have a recipe that calls for 1 teaspoon of resinferatoxin, but you feel uncomfortable serving foods with "toxins" in them. How much capsaicin could you substitute instead?
What protein is necessary for packaging acetylcholine into synaptic vesicles?
Chapter 29 Solutions
BIOLOGY-CONCEPTS+APP.CHAP 1-15>CUSTOM<
Ch. 29 - ______ relay messages from the brain and spinal...Ch. 29 - Prob. 2SACh. 29 - Action potentials occur when ______. a. potassium...Ch. 29 - Neurotransmitters are released by _______. a. axon...Ch. 29 - Prob. 5SACh. 29 - Prob. 6SACh. 29 - Prob. 7SACh. 29 - Prob. 8SACh. 29 - Prob. 9SACh. 29 - Prob. 10SA
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- 1. Match each vocabulary term to its best descriptor A. affinity B. efficacy C. inert D. mimic E. how drugs move through body F. how drugs bind Kd Bmax Agonist Antagonist Pharmacokinetics Pharmacodynamicsarrow_forward50 mg dose of a drug is given orally to a patient. The bioavailability of the drug is 0.2. What is the volume of distribution of the drug if the plasma concentration is 1 mg/L? Be sure to provide units.arrow_forwardDetermine Kd and Bmax from the following Scatchard plot. Make sure to include units.arrow_forward
- Choose a catecholamine neurotransmitter and describe/draw the components of the synapse important for its signaling including synthesis, packaging into vesicles, receptors, transporters/degradative enzymes. Describe 2 drugs that can act on this system.arrow_forwardThe following figure is from Caterina et al. The capsaicin receptor: a heat activated ion channel in the pain pathway. Nature, 1997. Black boxes indicate capsaicin, white circles indicate resinferatoxin. a) Which has a higher potency? b) Which is has a higher efficacy? c) What is the approximate Kd of capsaicin in uM? (you can round to the nearest power of 10)arrow_forwardWhat is the rate-limiting-step for serotonin synthesis?arrow_forward
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