Mastering Biology with Pearson eText -- Standalone Access Card -- for Campbell Biology (10th Edition)
10th Edition
ISBN: 9780321833143
Author: Jane B. Reece, Lisa A. Urry, Michael L. Cain, Steven A. Wasserman, Peter V. Minorsky, Robert B. Jackson
Publisher: PEARSON
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Chapter 28, Problem 9TYU
WRITE ABOUT A THEME: INTERACTIONS Organisms interact with each other and the physical environment. In a short essay (100–150 words), explain how the response of diatom populations to a drop in nutrient availability can affect both other organisms and aspects of the physical environment (such as carbon dioxide concentrations).
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Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug:
(a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate)
(b) Estimate the time for maximum plasma concentration (tmax).
(c) Estimate the maximum plasma concentration (Cmax).
(d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.)
(e)…
Chapter 28 Solutions
Mastering Biology with Pearson eText -- Standalone Access Card -- for Campbell Biology (10th Edition)
Ch. 28.1 - Cite at least four examples of structural and...Ch. 28.1 - Summarize the role of endosymbiosis in eukaryotic...Ch. 28.1 - Prob. 3CCCh. 28.2 - Why do some biologists describe the mitochondria...Ch. 28.2 - WHAT IF? DNA sequence data for a diplomonad, a...Ch. 28.3 - Explain why forams have such a well-preserved...Ch. 28.3 - WHAT IF? Would you expect the plastid DNA of...Ch. 28.3 - Prob. 3CCCh. 28.3 - Prob. 4CCCh. 28.4 - Contrast red algae and brown algae.
Ch. 28.4 - Why is it accurate to say that Ulva is truly...Ch. 28.4 - Prob. 3CCCh. 28.5 - Contrast the pseudopodia of amoebozoans and...Ch. 28.5 - Prob. 2CCCh. 28.5 - Prob. 3CCCh. 28.6 - Justify the claim that photosynthetic protists are...Ch. 28.6 - Prob. 2CCCh. 28.6 - WHAT IF? High water temperatures and pollution...Ch. 28.6 - MAKE CONNECTIONS The bacterium Wolbachia is a...Ch. 28 - Describe similarities and differences between...Ch. 28 - What evidence indicates that the excavates form a...Ch. 28 - Prob. 28.3CRCh. 28 - On what basis do systematists place plants in the...Ch. 28 - Describe a key feature for each of the main...Ch. 28 - Prob. 28.6CRCh. 28 - Plastids that are Surrounded by more than two...Ch. 28 - Biologists think that endosymbiosis gave rise to...Ch. 28 - Prob. 3TYUCh. 28 - According to the phylogeny presented in this...Ch. 28 - In a life cycle with alternation of generations,...Ch. 28 - Based on the phylogenetic tree in Figure 28.2,...Ch. 28 - Prob. 7TYUCh. 28 - SCIENTIFIC INQUIRY Applying the If then logic of...Ch. 28 - WRITE ABOUT A THEME: INTERACTIONS Organisms...Ch. 28 - SYNTHESIZE YOUR KNOWLEDGE This micrograph show's a...
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