ANATOMY & PHYSIOLOGY: AN INTEGRATIVE AP
3rd Edition
ISBN: 9781264013470
Author: McKinley
Publisher: MCGRAW-HILL LEARNING SOLN.(CC)
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Textbook Question
Chapter 28, Problem 7DYB
_____ 7. Spermatogonia divide by mitosis to form a new spermatogonium and
- a. a sperm.
- b. spermatids.
- c. a primary spermatocyte.
- d. zygotes.
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Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug:
(a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate)
(b) Estimate the time for maximum plasma concentration (tmax).
(c) Estimate the maximum plasma concentration (Cmax).
(d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.)
(e)…
Chapter 28 Solutions
ANATOMY & PHYSIOLOGY: AN INTEGRATIVE AP
Ch. 28.1 - Prob. 1LOCh. 28.1 - What general components make up the reproductive...Ch. 28.1 - Prob. 2LOCh. 28.1 - What hormones begin to be secreted at puberty, and...Ch. 28.1 - Prob. 3LOCh. 28.1 - What are the components of the urogenital...Ch. 28.2 - Prob. 4LOCh. 28.2 - Prob. 5LOCh. 28.2 - How do sex chromosomes differ from autosomes?Ch. 28.2 - Prob. 5WDL
Ch. 28.2 - Prob. 6LOCh. 28.2 - LEARNING OBJECTIVE
7. Describe events during...Ch. 28.2 - Prob. 8LOCh. 28.2 - Prob. 6WDLCh. 28.2 - Prob. 7WDLCh. 28.2 - Prob. 9LOCh. 28.2 - Prob. 8WDLCh. 28.2 - Prob. 9WDLCh. 28.2 - Prob. 10LOCh. 28.2 - Prob. 10WDLCh. 28.3 - LEARNING OBJECTIVE
11. Describe the gross and...Ch. 28.3 - Prob. 12LOCh. 28.3 - What are the broad ligament, ovarian ligament, and...Ch. 28.3 - How are the primordial, primary, secondary, and...Ch. 28.3 - Prob. 13LOCh. 28.3 - Prob. 14LOCh. 28.3 - Prob. 15LOCh. 28.3 - Prob. 1WDTCh. 28.3 - What follicles are present at birth? What...Ch. 28.3 - Prob. 14WDLCh. 28.3 - What are the three phases of the ovarian cycle,...Ch. 28.3 - Prob. 16LOCh. 28.3 - LEARNING OBJECTIVE
17. List the functions of the...Ch. 28.3 - Prob. 18LOCh. 28.3 - What are the four segments of the uterine tubes,...Ch. 28.3 - Prob. 17WDLCh. 28.3 - Prob. 18WDLCh. 28.3 - Prob. 19LOCh. 28.3 - Prob. 20LOCh. 28.3 - Prob. 21LOCh. 28.3 - Prob. 2WDTCh. 28.3 - What are the three phases of the uterine cycle,...Ch. 28.3 - Compare and contrast the ovarian and uterine...Ch. 28.3 - Prob. 22LOCh. 28.3 - What are the individual components of the female...Ch. 28.3 - Prob. 23LOCh. 28.3 - Prob. 24LOCh. 28.3 - Prob. 22WDLCh. 28.3 - Prob. 23WDLCh. 28.3 - Prob. 25LOCh. 28.3 - Prob. 24WDLCh. 28.4 - LEARNING OBJECTIVE
26. Describe the gross anatomy...Ch. 28.4 - How does the scrotum help regulate the temperature...Ch. 28.4 - LEARNING OBJECTIVE
27. Describe the gross anatomy...Ch. 28.4 - LEARNING OBJECTIVE
28. Explain the process of...Ch. 28.4 - LEARNING OBJECTIVE
29. Compare and contrast...Ch. 28.4 - WHAT DO YOU THINK?
3 If a man’s testes were...Ch. 28.4 - What are the major cell types in the seminiferous...Ch. 28.4 - What hormones are produced by the interstitial...Ch. 28.4 - How does a spermatogonium divide to produce...Ch. 28.4 - Prob. 29WDLCh. 28.4 - Prob. 30LOCh. 28.4 - LEARNING OBJECTIVE
31. Trace the pathway that...Ch. 28.4 - Prob. 30WDLCh. 28.4 - Prob. 32LOCh. 28.4 - Prob. 33LOCh. 28.4 - Prob. 34LOCh. 28.4 - WHAT DO YOU THINK?
4 If a man has a vasectomy, is...Ch. 28.4 - What are the specific functions of the accessory...Ch. 28.4 - How is seminal fluid different from semen?Ch. 28.4 - LEARNING OBJECTIVE
35. Describe the structure and...Ch. 28.4 - What are the similarities and differences between...Ch. 28.4 - Prob. 36LOCh. 28.4 - Prob. 37LOCh. 28.4 - Prob. 34WDLCh. 28.4 - Prob. 35WDLCh. 28.5 - Prob. 38LOCh. 28.5 - Prob. 39LOCh. 28.5 - Prob. 36WDLCh. 28.5 - Prob. 40LOCh. 28.5 - Prob. 37WDLCh. 28.5 - Prob. 41LOCh. 28.5 - Prob. 42LOCh. 28.5 - Prob. 38WDLCh. 28.5 - Prob. 39WDLCh. 28.5 - Prob. 43LOCh. 28.5 - Prob. 40WDLCh. 28.5 - Prob. 44LOCh. 28.5 - LEARNING OBJECTIVE
45. List some of the common...Ch. 28.5 - What factors affect the age that menarche first...Ch. 28.5 - Prob. 46LOCh. 28.5 - Prob. 47LOCh. 28.5 - Prob. 42WDLCh. 28 - _____ 1. The female homologue to the glans of the...Ch. 28 - _____ 2. Ovulation occurs due to a dramatic peak...Ch. 28 - _____ 3. Which statement is accurate about the...Ch. 28 - _____ 4. Which structure contains a primary...Ch. 28 - _____ 5. In the male, what cells produce...Ch. 28 - Prob. 6DYBCh. 28 - _____ 7. Spermatogonia divide by mitosis to form a...Ch. 28 - _____ 8. Sperm are stored in the _____, where they...Ch. 28 - _____ 9. Which statement is accurate about the...Ch. 28 - _____ 10. The paramesonephric ducts in the embryo...Ch. 28 - What are some anatomic similarities between the...Ch. 28 - What hormones are associated with the female...Ch. 28 - Do You Know the Basics?
13. Describe how a primary...Ch. 28 - List the uterine wall layers, and describe the...Ch. 28 - Compare and contrast the ovarian cycle phases and...Ch. 28 - Describe the relationship among the hypothalamus,...Ch. 28 - What is the function of sustentacular cells in the...Ch. 28 - Describe the process of spermatogenesis, including...Ch. 28 - How do erection and ejaculation occur in the male?Ch. 28 - What structures are formed from the...Ch. 28 - Prob. 1CALCh. 28 - Prob. 2CALCh. 28 - The physician reviews Luisas and Victors blood...Ch. 28 - Prob. 4CALCh. 28 - Prob. 5CALCh. 28 - Prob. 1CSLCh. 28 - Caitlyn had unprotected sex with her fianc...Ch. 28 - Prob. 3CSL
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