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ANATOMY+PHYSIOLOGY(LL)-W/CONNECT ACCESS
4th Edition
ISBN: 9781266364051
Author: McKinley
Publisher: MCG
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Chapter 28, Problem 4CAL
Summary Introduction
Introduction:
Sexually transmitted infections (STIs) or sexually transmitted diseases can be spread by sexual contact between two persons. Bacteria and viruses both serve as the vectors of STIs. If both parents and any of the parent is infected by STI, then inheritance of STI is not necessary. Some STIs do no inherit from one generation to another generation.
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Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug:
(a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate)
(b) Estimate the time for maximum plasma concentration (tmax).
(c) Estimate the maximum plasma concentration (Cmax).
(d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.)
(e)…
Chapter 28 Solutions
ANATOMY+PHYSIOLOGY(LL)-W/CONNECT ACCESS
Ch. 28.1 - What general components make up the reproductive...Ch. 28.1 - What hormones begin to be secreted at puberty, and...Ch. 28.1 - What are the components of the urogenital...Ch. 28.2 - How do sex chromosomes differ from autosomes?Ch. 28.2 - Prob. 5WDYLCh. 28.2 - Prob. 6WDYLCh. 28.2 - Prob. 7WDYLCh. 28.2 - Prob. 8WDYLCh. 28.2 - Prob. 9WDYLCh. 28.2 - Prob. 10WDYL
Ch. 28.3 - Prob. 11WDYLCh. 28.3 - Prob. 12WDYLCh. 28.3 - Prob. 13WDYLCh. 28.3 - Prob. 14WDYLCh. 28.3 - What are the three phases of the ovarian cycle,...Ch. 28.3 - What are the four segments of the uterine tubes,...Ch. 28.3 - Prob. 17WDYLCh. 28.3 - Prob. 18WDYLCh. 28.3 - What are the three phases of the uterine cycle,...Ch. 28.3 - Compare and contrast the ovarian and uterine...Ch. 28.3 - What are the individual components of the female...Ch. 28.3 - Prob. 22WDYLCh. 28.3 - Prob. 23WDYLCh. 28.3 - Prob. 24WDYLCh. 28.4 - How does the scrotum help regulate the temperature...Ch. 28.4 - What are the major cell types in the seminiferous...Ch. 28.4 - What hormones are produced by the interstitial...Ch. 28.4 - How does a spermatogonium divide to produce...Ch. 28.4 - Prob. 29WDYLCh. 28.4 - Prob. 30WDYLCh. 28.4 - What are the specific functions of the accessory...Ch. 28.4 - How is seminal fluid different from semen?Ch. 28.4 - What are the similarities and differences between...Ch. 28.4 - Prob. 34WDYLCh. 28.4 - Prob. 35WDYLCh. 28.5 - Prob. 36WDYLCh. 28.5 - Prob. 37WDYLCh. 28.5 - Prob. 38WDYLCh. 28.5 - Prob. 39WDYLCh. 28.5 - Prob. 40WDYLCh. 28.5 - What factors affect the age that menarche first...Ch. 28.5 - Prob. 42WDYLCh. 28 - _____ 1. The female homologue to the glans of the...Ch. 28 - _____ 2. Ovulation occurs due to a dramatic peak...Ch. 28 - _____ 3. Which statement is accurate about the...Ch. 28 - _____ 4. Which structure contains a primary...Ch. 28 - _____ 5. In the male, what cells produce...Ch. 28 - Prob. 6DYKBCh. 28 - _____ 7. Spermatogonia divide by mitosis to form a...Ch. 28 - _____ 8. Sperm are stored in the _____, where they...Ch. 28 - _____ 9. Which statement is accurate about the...Ch. 28 - _____ 10. The paramesonephric ducts in the embryo...Ch. 28 - What are some anatomic similarities between the...Ch. 28 - What hormones are associated with the female...Ch. 28 - Prob. 13DYKBCh. 28 - List the uterine wall layers, and describe the...Ch. 28 - Compare and contrast the ovarian cycle phases and...Ch. 28 - Describe the relationship among the hypothalamus,...Ch. 28 - What is the function of sustentacular cells in the...Ch. 28 - Describe the process of spermatogenesis, including...Ch. 28 - How do erection and ejaculation occur in the male?Ch. 28 - What structures are formed from the...Ch. 28 - Prob. 1CALCh. 28 - Prob. 2CALCh. 28 - The physician reviews Luisas and Victors blood...Ch. 28 - Prob. 4CALCh. 28 - Prob. 5CALCh. 28 - Prob. 1CSLCh. 28 - Caitlyn had unprotected sex with her fianc...Ch. 28 - Prob. 3CSL
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