LABORATORY MANUAL FOR HUMAN ANATOMY & PH
4th Edition
ISBN: 9781260254426
Author: Martin
Publisher: MCG
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Textbook Question
Chapter 28, Problem 3.13A
Spinal nerves L4 through S4 form a _______________________ plexus.
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1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple different routes of administration provides greater insight than just a single route of administration alone. The following data was collected in 250 g rats following bolus iv, oral (po), and intraperitoneal (ip) administration.Using this data and set of graphs, determine:
(a) k, C0, V, and AUC* for the bolus iv data (b) k, ka, B1, and AUC* for the po data (c) k, ka, B1, and AUC* for the ip data (d) relative bioavailability for po vs ip, Fpo/Fip (e) absolute po bioavailability, (f)Fpo absolute ip bioavailability, Fip
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2. Drug quantification from plasma is commonly performed by using techniques such as HPLC or LC/MS. However, these methods do have limitations, and investigators may choose to use a radiolabeled analog of a drug instead. Radioligands are molecules that contain radioactive isotopes, commonly 3H or 14C. This technique allows investigators to quantify drug concentration from radiation measurements. The following measurements were made in 250 g rats following oral administration of 18.2 µCi of a 14C-labeled drug of interest: Time (min) Plasma Radiation Levels (µCi/L) 0 0.0 2 9.7 4 19.2 7 25.3 9 37.8 12 39.6 14 45.8 17 48.8 20 52.0 25 56.4 30 59.2 35 60.1 40 61.1 45 62.1 50 62.8 60 63.1 70 62.1 80 60.1 90 57.3 100 55.5 110 53.7 120 52.2 150 48.0 180 45.0 240 39.0
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Chapter 28 Solutions
LABORATORY MANUAL FOR HUMAN ANATOMY & PH
Ch. 28 - The ____________ is the most superficial membrane...Ch. 28 - The inferior end of the adult spinal cord...Ch. 28 - Prob. 3PLCh. 28 - Which of the following is not part of the gray...Ch. 28 - The central canal of the spinal cord is located...Ch. 28 - The brachial plexus is formed from components of...Ch. 28 - There are eight pairs of cervical spinal nerves....Ch. 28 - The major ascending (sensory) and descending...Ch. 28 - Match the terms in column A with the descriptions...Ch. 28 - Prob. F28.14A
Ch. 28 - The spinal cord gives rise to 31 pairs...Ch. 28 - The bulge in the spinal cord that gives off nerves...Ch. 28 - The bulge in the spinal cord that gives off nerves...Ch. 28 - The ______________ is a groove that extends the...Ch. 28 - In a spinal cord cross section, the posterior...Ch. 28 - The axons of motor neurons are found in the...Ch. 28 - The _______________ connects the gray matter on...Ch. 28 - The _______ in the gray commissure of the spinal...Ch. 28 - The white matter of the spinal cord is divided...Ch. 28 - There are ______________________ pairs of cervical...Ch. 28 - There are ______________________ pairs of sacral...Ch. 28 - Cervical spinal nerve pair C1 originates between...Ch. 28 - Spinal nerves L4 through S4 form a...Ch. 28 - The gray matter of the spinal cord is divided into...Ch. 28 - The spinal cord ends just inferior to L1 in a...Ch. 28 - Severing the ______________________ nerves of the...Ch. 28 - The inferior and superior gluteal nerves of the...Ch. 28 - To block chronic pain in a patient, sometimes...Ch. 28 - Prob. 4.2ACh. 28 - Injuries to the vertebral column and spinal cord...Ch. 28 - Why are intramuscular injections given in the...Ch. 28 - Prob. 4.2CT
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