CAMPBELL'S BIOLOGY 12E PERUSALL
12th Edition
ISBN: 9780135858080
Author: Urry
Publisher: PERUSALL
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Chapter 27.6, Problem 3CC
Summary Introduction
To explain: How your diet affects the prokaryotic species that live in your digestive tract.
Concept introduction:
Human digestive tract inhabits around 500-1000 types of bacteria such as Bifidobacterium, Lactobacillus, Escherichia, Clostridium, Bacteroides, and so on. These bacteria produce various bioactive compounds, help in breaking down the food components and producing essential vitamins which impact the human health. A major change in the composition may have a negative influence on health; therefore a balance in the microbiota is necessary.
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Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug:
(a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate)
(b) Estimate the time for maximum plasma concentration (tmax).
(c) Estimate the maximum plasma concentration (Cmax).
(d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.)
(e)…
Chapter 27 Solutions
CAMPBELL'S BIOLOGY 12E PERUSALL
Ch. 27.1 - Describe two adaptations that enable prokaryotes...Ch. 27.1 - Contrast the cellular and DNA structures of...Ch. 27.1 - Prob. 3CCCh. 27.2 - Although rare on a per gene basis, new mutations...Ch. 27.2 - Distinguish between the three mechanisms by which...Ch. 27.2 - In a rapidly changing environment, which bacterial...Ch. 27.3 - Distinguish between the four major modes of...Ch. 27.3 - A bacterium requires only the amino acid...Ch. 27.3 - WHAT IF? Describe what you might eat for a...Ch. 27.4 - Explain how molecular systematics and metagenomics...
Ch. 27.4 - Prob. 2CCCh. 27.5 - Explain how prokaryotes, though small, can be...Ch. 27.5 - MAKE CONNECTIONS Review Figure 10.6. Then...Ch. 27.6 - Identify at least two ways that prokaryotes have...Ch. 27.6 - Prob. 2CCCh. 27.6 - Prob. 3CCCh. 27 - Describe features of prokaryotes that enable them...Ch. 27 - Mutations are rare and prokaryotes reproduce...Ch. 27 - Describe the range of prokaryotic metabolic...Ch. 27 - How have molecular data informed prokaryotic...Ch. 27 - In what ways are prokaryotes key to the survivaI...Ch. 27 - Prob. 27.6CRCh. 27 - Genetic variation in bacterial populations cannot...Ch. 27 - Photoautotrophs use (A) light as an energy source...Ch. 27 - Which of the following statements is not true? (A)...Ch. 27 - Prob. 4TYUCh. 27 - Prob. 5TYUCh. 27 - Prob. 6TYUCh. 27 - Prob. 7TYUCh. 27 - SCIENTIFIC INQUIRY INTERPRET THE DATA The...Ch. 27 - WRITE ABOUT A THEME: ENERGY In a short essay...Ch. 27 - SYNTHESIZE YOUR KNOWLEDGE Explain how the small...
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Prokaryotic vs. Eukaryotic Cells (Updated); Author: Amoeba Sisters;https://www.youtube.com/watch?v=Pxujitlv8wc;License: Standard youtube license