Anatomy & Physiology: The Unity of Form and Function (Standalone Book)
7th Edition
ISBN: 9780073403717
Author: Kenneth S. Saladin Dr.
Publisher: McGraw-Hill Education
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Chapter 27.2, Problem 10BYGO
Summary Introduction
Introduction:
The penis is an external reproductive organ of the male. It is used in sexual intercourse with females and for the semen ejaculation. It also serves as the male urogenital organ in excretion of urine. The penis consists of muscular architecture which helps the penis in erection during sexual arousal.
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Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug:
(a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate)
(b) Estimate the time for maximum plasma concentration (tmax).
(c) Estimate the maximum plasma concentration (Cmax).
(d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.)
(e)…
Chapter 27 Solutions
Anatomy & Physiology: The Unity of Form and Function (Standalone Book)
Ch. 27.1 - Prob. 1BYGOCh. 27.1 - Prob. 2BYGOCh. 27.1 - Prob. 3BYGOCh. 27.1 - Prob. 4BYGOCh. 27.1 - Prob. 5BYGOCh. 27.1 - Prob. 1AYLOCh. 27.1 - Prob. 2AYLOCh. 27.1 - Prob. 3AYLOCh. 27.1 - Prob. 4AYLOCh. 27.1 - Prob. 5AYLO
Ch. 27.1 - Prob. 6AYLOCh. 27.1 - Prob. 7AYLOCh. 27.1 - Prob. 8AYLOCh. 27.2 - Prob. 6BYGOCh. 27.2 - Prob. 7BYGOCh. 27.2 - Prob. 8BYGOCh. 27.2 - Prob. 9BYGOCh. 27.2 - Prob. 10BYGOCh. 27.2 - Prob. 1AYLOCh. 27.2 - Prob. 2AYLOCh. 27.2 - Prob. 3AYLOCh. 27.2 - Prob. 4AYLOCh. 27.2 - Prob. 5AYLOCh. 27.2 - Prob. 6AYLOCh. 27.2 - Prob. 7AYLOCh. 27.2 - Prob. 8AYLOCh. 27.2 - Prob. 9AYLOCh. 27.3 - Prob. 11BYGOCh. 27.3 - Prob. 12BYGOCh. 27.3 - Prob. 13BYGOCh. 27.3 - Prob. 14BYGOCh. 27.3 - Prob. 15BYGOCh. 27.3 - Prob. 1AYLOCh. 27.3 - Prob. 2AYLOCh. 27.3 - Prob. 3AYLOCh. 27.3 - Prob. 4AYLOCh. 27.3 - Prob. 5AYLOCh. 27.3 - Prob. 6AYLOCh. 27.4 - Prob. 16BYGOCh. 27.4 - Prob. 17BYGOCh. 27.4 - Prob. 18BYGOCh. 27.4 - Prob. 1AYLOCh. 27.4 - Prob. 2AYLOCh. 27.4 - Prob. 3AYLOCh. 27.4 - Prob. 4AYLOCh. 27.4 - Prob. 5AYLOCh. 27.4 - Prob. 6AYLOCh. 27.4 - Prob. 7AYLOCh. 27.4 - Prob. 8AYLOCh. 27.4 - Prob. 9AYLOCh. 27.4 - Prob. 10AYLOCh. 27.4 - Prob. 11AYLOCh. 27.5 - Prob. 19BYGOCh. 27.5 - Prob. 20BYGOCh. 27.5 - Prob. 1AYLOCh. 27.5 - Prob. 2AYLOCh. 27.5 - Prob. 3AYLOCh. 27.5 - Prob. 4AYLOCh. 27.5 - Prob. 5AYLOCh. 27.5 - Prob. 6AYLOCh. 27.5 - Prob. 7AYLOCh. 27 - The ductus deferens develops from the _______.of...Ch. 27 - The protein that clots and causes the stickiness...Ch. 27 - The expulsion of semen occurs when the...Ch. 27 - Prob. 4TYRCh. 27 - The penis is attached to the pubic arch by crura...Ch. 27 - The first hormone secreted at the onset of puberty...Ch. 27 - Prob. 7TYRCh. 27 - Four spermatozoa arise from each a. primordial...Ch. 27 - The point in meiosis at which sister chromatids...Ch. 27 - Blood is forced out of the penile lacunae by...Ch. 27 - Prob. 11TYRCh. 27 - Prob. 12TYRCh. 27 - Prob. 13TYRCh. 27 - Prob. 14TYRCh. 27 - Prob. 15TYRCh. 27 - Prob. 16TYRCh. 27 - Prob. 17TYRCh. 27 - Prob. 18TYRCh. 27 - Erection of the penis occurs when nitric oxide...Ch. 27 - A sperm penetrates the egg by means of enzymes in...Ch. 27 - crypto-Ch. 27 - Prob. 2BYMVCh. 27 - Prob. 3BYMVCh. 27 - Prob. 4BYMVCh. 27 - Prob. 5BYMVCh. 27 - meio-Ch. 27 - Prob. 7BYMVCh. 27 - Prob. 8BYMVCh. 27 - someCh. 27 - Prob. 10BYMVCh. 27 - Prob. 1TFCh. 27 - Prob. 2TFCh. 27 - Prob. 3TFCh. 27 - Prob. 4TFCh. 27 - A high testosterone level makes a fetus develop a...Ch. 27 - Prob. 6TFCh. 27 - Prob. 7TFCh. 27 - Prob. 8TFCh. 27 - Male menopause is the cessation of sperm...Ch. 27 - ? True or False
10. Erection is caused by...Ch. 27 - Prob. 1TYCCh. 27 - Prob. 2TYCCh. 27 - Prob. 3TYCCh. 27 - Why is it possible for spermatogonia to be outside...Ch. 27 - A 68-year-old man taking medication for...
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