
23-Year-Old Female with Menstrual Irregularity
Jasmine Herrera, 23, has been referred to the endocrinology clinic. She is very overweight, with obvious acne and facial hair. She complains of irregular menstrual cycles. “My husband and I want to use the rhythm method," she says, “but I don’t have any rhythm!”
5. Jasmine’s blood tests reveal very high levels of androgens. She is diagnosed with polycystic ovary syndrome (PCOS). In this syndrome, the woman develops high levels of androgens and many vesicular follicles, but has reduced fertility because few follicles are ovulated and the timing of their release is unpredictable. Part of the profile of PCOS is that LH levels are high. How would this lead to androgen excess, and what clinical evidence of androgen excess does Jasmine have?

Trending nowThis is a popular solution!

Chapter 27 Solutions
Human Anatomy & Physiology Plus Modified Mastering A&P with Pearson eText -- Access Card Package 11th edition
- The following table is from Kumar et. al. Highly Selective Dopamine D3 Receptor (DR) Antagonists and Partial Agonists Based on Eticlopride and the D3R Crystal Structure: New Leads for Opioid Dependence Treatment. J. Med Chem 2016.arrow_forwardThe following figure is from Caterina et al. The capsaicin receptor: a heat activated ion channel in the pain pathway. Nature, 1997. Black boxes indicate capsaicin, white circles indicate resinferatoxin. You are a chef in a fancy new science-themed restaurant. You have a recipe that calls for 1 teaspoon of resinferatoxin, but you feel uncomfortable serving foods with "toxins" in them. How much capsaicin could you substitute instead?arrow_forwardWhat protein is necessary for packaging acetylcholine into synaptic vesicles?arrow_forward
- 1. Match each vocabulary term to its best descriptor A. affinity B. efficacy C. inert D. mimic E. how drugs move through body F. how drugs bind Kd Bmax Agonist Antagonist Pharmacokinetics Pharmacodynamicsarrow_forward50 mg dose of a drug is given orally to a patient. The bioavailability of the drug is 0.2. What is the volume of distribution of the drug if the plasma concentration is 1 mg/L? Be sure to provide units.arrow_forwardDetermine Kd and Bmax from the following Scatchard plot. Make sure to include units.arrow_forward
- Choose a catecholamine neurotransmitter and describe/draw the components of the synapse important for its signaling including synthesis, packaging into vesicles, receptors, transporters/degradative enzymes. Describe 2 drugs that can act on this system.arrow_forwardThe following figure is from Caterina et al. The capsaicin receptor: a heat activated ion channel in the pain pathway. Nature, 1997. Black boxes indicate capsaicin, white circles indicate resinferatoxin. a) Which has a higher potency? b) Which is has a higher efficacy? c) What is the approximate Kd of capsaicin in uM? (you can round to the nearest power of 10)arrow_forwardWhat is the rate-limiting-step for serotonin synthesis?arrow_forward
- Nutrition Through the Life Cycle (MindTap Course ...Health & NutritionISBN:9781305628007Author:Judith E. BrownPublisher:Cengage Learning
- Understanding Health Insurance: A Guide to Billin...Health & NutritionISBN:9781337679480Author:GREENPublisher:CengageLifetime Physical Fitness & WellnessHealth & NutritionISBN:9781337677509Author:HOEGERPublisher:Cengage
