ANATOMY & PHYSIOLOGY: AN INTEGRATIVE AP
3rd Edition
ISBN: 9781264013470
Author: McKinley
Publisher: MCGRAW-HILL LEARNING SOLN.(CC)
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Chapter 27, Problem 20DYB
Summary Introduction
To explain:
The hormonal and neural induced changes when an individual is cold.
Concept introduction:
Endotherms are organisms who are able to regulate the temperature by balancing heat generation and heat loss. They are able to maintain a favorable body temperature. When the temperature of the body rises or drops, there are some changes occurring that lead to heat release or heat generation respectively.
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Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug:
(a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate)
(b) Estimate the time for maximum plasma concentration (tmax).
(c) Estimate the maximum plasma concentration (Cmax).
(d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.)
(e)…
Chapter 27 Solutions
ANATOMY & PHYSIOLOGY: AN INTEGRATIVE AP
Ch. 27.1 - Prob. 1LOCh. 27.1 - Prob. 2LOCh. 27.1 - Prob. 3LOCh. 27.1 - List the six nutrients required by the body.Ch. 27.1 - Prob. 2WDLCh. 27.1 - Prob. 3WDLCh. 27.2 - Prob. 4LOCh. 27.2 - Prob. 4WDLCh. 27.2 - Prob. 5WDLCh. 27.2 - Prob. 5LO
Ch. 27.2 - Prob. 6LOCh. 27.2 - Prob. 6WDLCh. 27.2 - Prob. 7LOCh. 27.2 - Prob. 8LOCh. 27.2 - Prob. 9LOCh. 27.2 - Prob. 7WDLCh. 27.2 - How may a vegetarian obtain all of the essential...Ch. 27.3 - LEARNING OBJECTIVE
10. Distinguish between...Ch. 27.3 - Prob. 11LOCh. 27.3 - LEARNING OBJECTIVE
12. Describe the difference...Ch. 27.3 - WHAT DID YOU THINK?
1 Predict what happens to the...Ch. 27.3 - Prob. 9WDLCh. 27.3 - Prob. 13LOCh. 27.3 - Prob. 14LOCh. 27.3 - What are the major minerals? The trace minerals?...Ch. 27.4 - Prob. 16LOCh. 27.4 - What categories of food are shown on the USDA...Ch. 27.4 - What is the purpose of the requirement for...Ch. 27.5 - Prob. 17LOCh. 27.5 - Prob. 13WDLCh. 27.5 - Prob. 18LOCh. 27.5 - Prob. 14WDLCh. 27.6 - Prob. 19LOCh. 27.6 - Prob. 15WDLCh. 27.6 - Prob. 16WDLCh. 27.6 - Prob. 20LOCh. 27.6 - Prob. 21LOCh. 27.6 - Prob. 2WDTCh. 27.6 - Prob. 17WDLCh. 27.6 - Prob. 22LOCh. 27.6 - Prob. 18WDLCh. 27.7 - Prob. 23LOCh. 27.7 - Prob. 24LOCh. 27.7 - Where in the biochemical pathway of cellular...Ch. 27.7 - Prob. 25LOCh. 27.7 - How is excess sugar (glucose) converted to fat...Ch. 27.8 - Prob. 26LOCh. 27.8 - Prob. 27LOCh. 27.8 - Prob. 3WDTCh. 27.8 - Prob. 21WDLCh. 27.8 - Prob. 28LOCh. 27.8 - Prob. 29LOCh. 27.8 - Prob. 22WDLCh. 27.8 - Prob. 23WDLCh. 27 - _____ 1. Which of the following is a nutrient? a....Ch. 27 - Prob. 2DYBCh. 27 - _____ 3. What is the major macronutrient in a...Ch. 27 - _____ 4. During the absorptive state a. blood...Ch. 27 - _____ 5. When the pancreas releases insulin, it...Ch. 27 - _____ 6. Which of the following nutrient...Ch. 27 - _____ 7. Which of the following conditions is not...Ch. 27 - _____ 8. Total metabolic rate increases under...Ch. 27 - _____ 9. All of the following are functions of the...Ch. 27 - Prob. 10DYBCh. 27 - Define nutrition.Ch. 27 - Prob. 12DYBCh. 27 - Prob. 13DYBCh. 27 - Prob. 14DYBCh. 27 - Define minerals, and give examples of their...Ch. 27 - Define nitrogen balance, and compare positive...Ch. 27 - Define the postabsorptive state. What is the major...Ch. 27 - Explain the function of the liver in the transport...Ch. 27 - Prob. 19DYBCh. 27 - Prob. 20DYBCh. 27 - An individual has recently adopted a vegetarian...Ch. 27 - Prob. 2CALCh. 27 - Prob. 3CALCh. 27 - Prob. 4CALCh. 27 - Prob. 5CALCh. 27 - Prob. 1CSLCh. 27 - Prob. 2CSLCh. 27 - Prob. 3CSL
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