Brock Biology of Microorganisms (15th Edition)
15th Edition
ISBN: 9780134261928
Author: Michael T. Madigan, Kelly S. Bender, Daniel H. Buckley, W. Matthew Sattley, David A. Stahl
Publisher: PEARSON
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Chapter 26.9, Problem 1MQ
- In what ways does the classical pathway of complement activation differ from the mannose-binding lectin and alternative pathways?
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Describe the complement system. Is the order ofprotein interactions important? Why or why not?Identify the components of the mannose-binding lectinpathway for complement activation.
What triggers the alternative pathway for complement activation?
What is meant by complement fi xation?
What are cytolysins?
Chapter 26 Solutions
Brock Biology of Microorganisms (15th Edition)
Ch. 26.1 - What major class of immune cells mediates an...Ch. 26.1 - Prob. 2MQCh. 26.1 - Compare and contrast the major features of innate...Ch. 26.2 - Describe host tissue specificity for pathogens.Ch. 26.2 - Identify physical and chemical barriers to...Ch. 26.2 - What other factors may control the outcome of an...Ch. 26.2 - Identify at least four mechanisms by which a...Ch. 26.3 - Describe the circulation of a leukocyte from the...Ch. 26.3 - What soluble molecules determine whether a...Ch. 26.3 - Cells involved in innate and adaptive immunity...
Ch. 26.4 - How does the development of B, T, and NK cells...Ch. 26.4 - Distinguish between the primary lymphoid organs...Ch. 26.4 - Leukocytes are differentiated white blood cells...Ch. 26.5 - Although technically not part of the immune...Ch. 26.5 - Describe the mechanisms by which circulating...Ch. 26.5 - Pathogens may colonize host tissues when...Ch. 26.6 - Identify a PAMP shared by a group of...Ch. 26.6 - Outline the general features of a signal...Ch. 26.6 - Innate recognition of common pathogens occurs...Ch. 26.7 - Identify the mechanism used by phagocytes to...Ch. 26.7 - Describe several reasons why phagocytes are not...Ch. 26.7 - Phagocytosis is the engulfing of infectious...Ch. 26.8 - Prob. 1MQCh. 26.8 - Identify the major symptoms of localized...Ch. 26.8 - Fever and inflammation, characterized by pain,...Ch. 26.9 - In what ways does the classical pathway of...Ch. 26.9 - What is opsonization, and how does opsonization...Ch. 26.9 - Why are the mannose-binding lectin and alternative...Ch. 26.9 - The complement system is composed of soluble...Ch. 26.10 - Prob. 1MQCh. 26.10 - Prob. 2MQCh. 26.10 - Prob. 1CRCh. 26 - Prob. 1AQCh. 26 - Describe the potential problems that would arise...Ch. 26 - Prob. 3AQCh. 26 - Prob. 4AQ
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- How can C3b be both a product of complement activation and an activator of the complement system?arrow_forwardWhat is the only known effect of deficiencies in complement components C5–C9? Explain this effect.arrow_forwardWhich pathway for activation of complement involves antibodies? Explain why.arrow_forward
- What is complement activation in the biological sensearrow_forwardThe classical complement pathway involves activation of the complement proteins in which of the following manners? 1) C3b binds to the microbial surface, with factors B, D, and P 2) C1 binds to antibodies bound to the microbe's surface 3) Fungal mannose sugars trigger complement proteins in the blood 4) C3b binds to antibodies bound to the microbial surfacearrow_forwardDescribe the initiation and activation of classical complement pathway.arrow_forward
- Which of the following complement components are generated during the classical pathway and bind independently to the membrane surface promoting immune adherence and opsonizing effects? C3b O C3d O C1q O C2arrow_forwardDescribe briefly the three effector functions of complement activation that result from the initial event of complement protein binding to peptidoglycans or LPSarrow_forwardWhat are TLRS? How does this work to ensure to prevent pathogens to cause diseases? Where are the locations of each TLRS? What are they exactly detecting specifically? How are cellular behavior changing after they detect pathogens via TLRS? How does complement get activated? Please explain three pathways of complement activation and end results of complement activation.arrow_forward
- Outline and describe the steps of Classical pathway of complement activation; from initiation to cell lysis. Then describe both the Alternative and Lectin pathways, indicating how they compare and how they differ from the classical pathway.arrow_forwardDistinguish between alternative complement pathway and Lectin pathway.arrow_forwardWhich of the following is true about complement? Check all that apply. Three pathways of complement, where classical and alternative, are activated by antibodies and lectin by spontaneous hydrolysis of C3 Complement pathways are activated in response to infections and involved in opsonization, phagocytosis and lysis of microbes The"b" subunit of complement such as C3b or C5b is deposited on the microbes, whereas the "a" subunit, C3a or C5a recruits phagocytic cells to the site of infection and promotes inflammation Alternative pathway is activated immediately due to presence of C3b because of spontaneous hydrolysis of C3, whereas classical pathways in several days after secretion of pathogen-specific antibodies Seven complement(C) proteins are made by liver and C5 is found in abundancearrow_forward
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