Chapter 26.7, Problem 16P

Interpretation Introduction

Interpretation:

Boc derivative are used to protect the amino group of α-amino acids. It happens by nucleophilic acyl substitution reaction.

Concept introduction:

Amino groups are often protected as their tert-butyloxycarbonyl amide (Boc) or fluorenylmethyloxycarbonyl amide (Fmoc) derivatives. The Boc groups are introduced by nucleophilic acyl substitution when the amino group reacts with di-tert-butyl dicarbonate.

To determine:

The mechanism for formation of a Boc derivative by reaction of an amino acid with di-tert-butyl dicarbonate.