Foundations in Microbiology
10th Edition
ISBN: 9781259705212
Author: Kathleen Park Talaro, Barry Chess Instructor
Publisher: McGraw-Hill Education
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Chapter 26.5, Problem 16ELO
16. Explain how aquatic environments vary in nutrient content.
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Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug:
(a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate)
(b) Estimate the time for maximum plasma concentration (tmax).
(c) Estimate the maximum plasma concentration (Cmax).
(d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.)
(e)…
Chapter 26 Solutions
Foundations in Microbiology
Ch. 26.1 - 1. Define microbial ecology and describe what it...Ch. 26.1 - Prob. 2ELOCh. 26.1 - 3. Differentiate between habitat and niche, using...Ch. 26.1 - 1. Present in outline form the levels of...Ch. 26.1 - 2. Compare the concepts of habitat and niche using...Ch. 26.2 - Prob. 4ELOCh. 26.2 - 5. Analyze trophic structures and nutritional...Ch. 26.2 - 6. Outline several types of ecological...Ch. 26.2 - Prob. 3CYPCh. 26.2 - Prob. 4CYP
Ch. 26.2 - Prob. 5CYPCh. 26.2 - Prob. 6CYPCh. 26.3 - 7. Summarize the main concepts pertaining to...Ch. 26.3 - 8. Discuss the primary participants in and...Ch. 26.3 - 9. Describe the forms in which nitrogen is found...Ch. 26.3 - 10. Indicate the main components of the sulfur and...Ch. 26.3 - Prob. 7CYPCh. 26.3 - Prob. 8CYPCh. 26.3 - Prob. 9CYPCh. 26.3 - Prob. 10CYPCh. 26.3 - 11. Describe nitrogen fixation, ammonification,...Ch. 26.3 - 12. What form of nitrogen is required by plants?...Ch. 26.3 - 13. Summarize the main stages in the cycling of...Ch. 26.3 - 14. Explain the processes of bioaccumulation and...Ch. 26.4 - 11. Describe the structure of soil and how it...Ch. 26.4 - Prob. 12ELOCh. 26.4 - 13. Explain how bioremediation relates to soil and...Ch. 26.5 - Prob. 14ELOCh. 26.5 - 15. Describe the structure of aquatic ecosystems.Ch. 26.5 - 16. Explain how aquatic environments vary in...Ch. 26.5 - 17. Relate the principles involved in water...Ch. 26.5 - Prob. 18ELOCh. 26.5 - 15. Describe the composition of the soil, the...Ch. 26.5 - Prob. 16CYPCh. 26.5 - 17. What are the roles of precipitation,...Ch. 26.5 - 18. What causes the formation of the epilimnion,...Ch. 26.5 - Prob. 19CYPCh. 26.5 - Prob. 20CYPCh. 26.5 - Prob. 21CYPCh. 26.5 - 22. Give specific examples of indicator organisms...Ch. 26.5 - 23. Describe two methods of water analysis.Ch. 26.L1 - 1. Which of the following is not a major...Ch. 26.L1 - Prob. 2MCQCh. 26.L1 - 3. The quantity of available nutrients _______...Ch. 26.L1 - Prob. 4MCQCh. 26.L1 - Prob. 5MCQCh. 26.L1 - Prob. 6MCQCh. 26.L1 - 7. Which of the following bacteria would be the...Ch. 26.L1 - Prob. 8MCQCh. 26.L1 - 9. An oligotrophic ecosystem would be most likely...Ch. 26.L1 - 10. Which of the following does not vary...Ch. 26.L1 - Prob. 1CSRCh. 26.L1 - 2. Increased average water temperature in Lake...Ch. 26.L1 - Prob. 3CSRCh. 26.L1 - Prob. 1WCCh. 26.L1 - Prob. 2WCCh. 26.L1 - Prob. 3WCCh. 26.L1 - 4. Draw a diagram that follows the effects of CO2...Ch. 26.L1 - Prob. 5WCCh. 26.L1 - Prob. 6WCCh. 26.L2 - 1. Biologists can set up an ecosystem in a small,...Ch. 26.L2 - 2. Observe the carbon and nitrogen cycles and...Ch. 26.L2 - Prob. 3CTCh. 26.L2 - 4. Why are organisms in the abyssal zone of the...Ch. 26.L2 - 5. a. What eventually happens to the nutrients...Ch. 26.L2 - 6. If we are to rely on microorganisms to...Ch. 26.L2 - Prob. 1VCCh. 26.L2 - 2. From chapter 8, Figure 8.27. What process does...
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- Select a diet and give a summary of the main components. Do a web search of the diet and choose one link that provides misinformation. Explain why the site itself and/or the information on the site is not credible. This should be a report. This site should be different from U.S News and World Report. For full credit, you must include the following information and elaborate in detail: The diet name The main components of the diet The misinformation website and link What misinformation is being provided in the other website and how did you determine it was not credible?arrow_forward1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple different routes of administration provides greater insight than just a single route of administration alone. The following data was collected in 250 g rats following bolus iv, oral (po), and intraperitoneal (ip) administration.Using this data and set of graphs, determine: (a) k, C0, V, and AUC* for the bolus iv data (b) k, ka, B1, and AUC* for the po data (c) k, ka, B1, and AUC* for the ip data (d) relative bioavailability for po vs ip, Fpo/Fip (e) absolute po bioavailability, (f)Fpo absolute ip bioavailability, Fip MAKE SURE ANSWERS HAVE UNITS if appropriate. SHOW ALL WORK, including equation used, variables used and each step to your solution.arrow_forward2. Drug quantification from plasma is commonly performed by using techniques such as HPLC or LC/MS. However, these methods do have limitations, and investigators may choose to use a radiolabeled analog of a drug instead. Radioligands are molecules that contain radioactive isotopes, commonly 3H or 14C. This technique allows investigators to quantify drug concentration from radiation measurements. The following measurements were made in 250 g rats following oral administration of 18.2 µCi of a 14C-labeled drug of interest: Time (min) Plasma Radiation Levels (µCi/L) 0 0.0 2 9.7 4 19.2 7 25.3 9 37.8 12 39.6 14 45.8 17 48.8 20 52.0 25 56.4 30 59.2 35 60.1 40 61.1 45 62.1 50 62.8 60 63.1 70 62.1 80 60.1 90 57.3 100 55.5 110 53.7 120 52.2 150 48.0 180 45.0 240 39.0 Note that a µCi is a measure of the amount of radioactivity and hence is a measure of the amount of drug present. Given that the oral bioavailability of this drug is known to be essentially 100%, estimate the following from this…arrow_forward
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