Seeley's Anatomy & Physiology
12th Edition
ISBN: 9781260399127
Author: VanPutte, Cinnamon
Publisher: MCGRAW-HILL HIGHER EDUCATION
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Chapter 26.4, Problem 37AYP
Describe how the presence of ADH causes the production of a small volume of concentrated urine.
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Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug:
(a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate)
(b) Estimate the time for maximum plasma concentration (tmax).
(c) Estimate the maximum plasma concentration (Cmax).
(d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.)
(e)…
Chapter 26 Solutions
Seeley's Anatomy & Physiology
Ch. 26.1 - Name the organs that make up the urinary system.Ch. 26.1 - List the functions performed by the kidneys, and...Ch. 26.2 - Describe the location, Size, and shown of the...Ch. 26.2 - Describe the renal capsule and the structures that...Ch. 26.2 - List the structures found at the hilum and in the...Ch. 26.2 - What is the functional unit of the kidney? Name...Ch. 26.2 - Distinguish between cortical and juxtamedullary...Ch. 26.2 - List the components of a renal corpuscle.Ch. 26.2 - Describe the structure of the Bowman capsule, the...Ch. 26.2 - Describe the structure of the afferent and...
Ch. 26.2 - Describe the structure and location of the...Ch. 26.2 - Explain blood supply for the kidney.Ch. 26.3 - Name the three general processes involved in...Ch. 26.3 - Contrast the rates of renal blood flow, renal...Ch. 26.3 - Prob. 15AYPCh. 26.3 - What is filtration pressure? How does glomerular...Ch. 26.3 - How do systemic blood pressure and afferent...Ch. 26.3 - Describe autoregulation.Ch. 26.3 - Prob. 19AYPCh. 26.3 - What is the direction of movement of substances in...Ch. 26.3 - Describe what happens to most of the filtrate that...Ch. 26.3 - On what side of therenal tubule cell does active...Ch. 26.3 - Describe how symportworks in the renal tubule.Ch. 26.3 - Name the substances that are moved by active and...Ch. 26.3 - Prob. 25AYPCh. 26.3 - Where does tubular secretion take place? What is...Ch. 26.3 - What substances are secreted? List the mechanisms...Ch. 26.3 - List the major mechanisms that create and maintain...Ch. 26.3 - Describe the roles of the loop of Henle, the vasa...Ch. 26.3 - Describe how the filtrate volume and concentration...Ch. 26.4 - Prob. 31AYPCh. 26.4 - How is angiotensinII activated? What effects does...Ch. 26.4 - Where is aldosterone produced? What factors...Ch. 26.4 - What are the effects of aldosterone on Na+ and CI+...Ch. 26.4 - Where is ADH produced? What factors stimulate an...Ch. 26.4 - How does ADH affect urine volume and...Ch. 26.4 - Describe how the presence of ADH causes the...Ch. 26.4 - How does the absence of ADH cause the production...Ch. 26.4 - Where is atrial natriuretic hormone produced,and...Ch. 26.5 - What is plasma clearance, and how is it...Ch. 26.5 - Prob. 41AYPCh. 26.5 - Describe how PAH is used to determine renal plasma...Ch. 26.5 - Explain the significance of tubular load and...Ch. 26.6 - What are the functions of the ureters, urinary...Ch. 26.6 - Prob. 45AYPCh. 26.6 - Prob. 46AYPCh. 26.6 - Prob. 47AYPCh. 26.6 - Prob. 48AYPCh. 26.7 - Discuss the effect of aging on the kidneys. Why do...Ch. 26 - Prob. 1RACCh. 26 - Prob. 2RACCh. 26 - Prob. 3RACCh. 26 - Prob. 4RACCh. 26 - Prob. 5RACCh. 26 - Prob. 6RACCh. 26 - Prob. 7RACCh. 26 - Prob. 8RACCh. 26 - If the glomerular capillary pressure is 40 mm Hg,...Ch. 26 - Prob. 10RACCh. 26 - Prob. 11RACCh. 26 - Prob. 12RACCh. 26 - Prob. 13RACCh. 26 - Prob. 14RACCh. 26 - Prob. 15RACCh. 26 - Prob. 16RACCh. 26 - Prob. 17RACCh. 26 - Which of the following contributes to the...Ch. 26 - Prob. 19RACCh. 26 - Prob. 20RACCh. 26 - Prob. 21RACCh. 26 - Prob. 22RACCh. 26 - ADH governs the a. Na+ pump of proximal convoluted...Ch. 26 - Prob. 24RACCh. 26 - The amount of a substance that passes through the...Ch. 26 - Prob. 26RACCh. 26 - Prob. 1CTCh. 26 - Harry is doing yard work one hot summer day and...Ch. 26 - Prob. 3CTCh. 26 - Prob. 4CTCh. 26 - Design a kidney that can produce hypostatic urine,...Ch. 26 - If only a very small amount of urea, instead of...Ch. 26 - Prob. 7CTCh. 26 - Marvin was driving too fast on a remote mountain...Ch. 26 - Which of the following will help compensate for...Ch. 26 - Renin-secreting tumors are usually found in the...Ch. 26 - Prob. 11CT
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