BIOLOGY:THE ESSENTIALS (LL) W/CONNECT
3rd Edition
ISBN: 9781260670929
Author: Hoefnagels
Publisher: MCG CUSTOM
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Chapter 26, Problem 3PIT
Summary Introduction
To add:
Neurotransmitter and ATP in the concept map.
Introduction:
A sliding filament model describes that muscle contracts when thin filaments slide between thick filaments and for this, actin and myosin must touch. The physical connection between the two types of filaments is the “head” portion of each myosin molecule that forms a cross-bridge when it contacts an actin molecule.
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Digoxin: Intravenous Bolus - Two Compartment Model
Drug
Digoxin
Route:
IV Bolus
Dose:
0.750 mg
Plasma Concentration Time Profile
Beta
Alpha
Time (hrs)
Conc (ng/ml)
LN
(ng/ml)
LN
(ng/ml)
LN
0.00
#NUM!
#NUM!
#NUM!
0.10
12.290
2.509
#NUM!
#NUMI
0.60
6.975
1.942
#NUM!
#NUMI
1.00
4.649
1.537
#NUM!
#NUMI
2.00
2.201
0.789
#NUM!
#NUM!
3.00
1.536
0.429
#NUM!
#NUM!
4.00
1.342
0.294
#NUM!
#NUM!
5.00
1.273
0.241
#NUM!
#NUMI
6.00
1.238
0.213
#NUM!
#NUM!
7.00
1.212
0.192
#NUM!
#NUM!
8.00
1.188
0.172
#NUMI
#NUM!
9.00
1.165
0.153
#NUM!
#NUMI
10.00
1.143
0.134
#NUMI
#NUM!
11.00
1.122
0.115
#NUM!
12.00
1.101
0.096
#NUMI
13.00
1.080
0.077
#NUMI
16.00
1.020
0.020
#NUMI
24.00
0.876
-0.132
#NUMI
Pharmacokinetic Parameters
Parameter
Value
Alpha
B
Beta
Units
ng/ml
hr-1
ng/ml
hr-1
CO
ng/ml
H.C
AUC
ng x hr/ml
Vc
Vbeta
Vss
C
L/hr
TK (alpha)
hr
TX (beta)
days
5+
F3
F4
F5
0+
F6
F7
%
6
95
14
#3
29
&
t
F8
F9
FW
EW
Linuron, a derivative of urea, is used as an herbicide. Linuron serum levels were measured in 4Kg
rabbits following a bolus IV injection of 10mg/kg.
Time (minutes)
Serum Linuron Levels (ug/ml)
following IV dose
10
15.48
20
8.60
30
5.90
45
3.78
60
2.42
90
1.49
120
0.93
180
0.60
240
0.41
300
0.29
360
0.22
Analyze this data and perform the necessary calculations to determine the following pharmacokinetic
parameters from the IV data: (5 points per parameter, 24 parameters/variables ■ 120 points
possible). You do NOT need to submit graphs or data tables.
Give the terminal regression line equation and R or R² value:
Give the x axis (name and units, if any) of the terminal line:
Give the y axis (name and units, if any) of the terminal line:
Give the residual regression line equation and R or R² value:
Give the x axis (name and units, if any) of the residual line:
Give the y axis (name and units, if any) of the residual line:
Chapter 26 Solutions
BIOLOGY:THE ESSENTIALS (LL) W/CONNECT
Ch. 26.1 - How do the skeletal and muscular systems interact?Ch. 26.1 - Prob. 2MCCh. 26.1 - Prob. 3MCCh. 26.2 - Prob. 1MCCh. 26.2 - Prob. 2MCCh. 26.3 - Prob. 1MCCh. 26.3 - Prob. 2MCCh. 26.3 - Prob. 3MCCh. 26.3 - Prob. 4MCCh. 26.3 - Prob. 5MC
Ch. 26.4 - Prob. 1MCCh. 26.4 - Prob. 2MCCh. 26.4 - Prob. 3MCCh. 26.4 - Prob. 4MCCh. 26.4 - Prob. 5MCCh. 26.5 - Prob. 1MCCh. 26.5 - What happens when a muscle cell can not generate...Ch. 26.6 - Prob. 1MCCh. 26.6 - Prob. 2MCCh. 26 - Prob. 1MCQCh. 26 - Prob. 2MCQCh. 26 - Prob. 3MCQCh. 26 - Prob. 4MCQCh. 26 - Prob. 5MCQCh. 26 - Prob. 6MCQCh. 26 - Prob. 7MCQCh. 26 - Prob. 8MCQCh. 26 - Prob. 9MCQCh. 26 - Distinguish among a hydrostatic skeleton, an...Ch. 26 - Explain the observation that animals with...Ch. 26 - Prob. 3WIOCh. 26 - Prob. 4WIOCh. 26 - Prob. 5WIOCh. 26 - Prob. 6WIOCh. 26 - Prob. 7WIOCh. 26 - Prob. 8WIOCh. 26 - Prob. 9WIOCh. 26 - How might your muscles lengthen when you stretch?...Ch. 26 - How do the effects of exercise or lack thereof...Ch. 26 - Prob. 12WIOCh. 26 - Search the Internet for disorders of the skeletal...Ch. 26 - What is role of calcium in bones? In muscle...Ch. 26 - The following table shows recent mens world-record...Ch. 26 - Prob. 1SLCh. 26 - Prob. 1PITCh. 26 - Prob. 2PITCh. 26 - Prob. 3PITCh. 26 - Prob. 4PIT
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