Bundle: Biology: The Unity and Diversity of Life, Loose-leaf Version, 14th + LMS Integrated for MindTap Biology, 2 terms (12 months) Printed Access Card
14th Edition
ISBN: 9781305775480
Author: Cecie Starr, Ralph Taggart, Christine Evers, Lisa Starr
Publisher: Cengage Learning
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Chapter 26, Problem 3DAA
Neanderthal Hair Color The MCIR gene regulates pigmentation in humans (Sections 14.1 and 15.l revisited), .so loss-of-function mutations in this gene affect hair and .skin color. A person with two mutated alleles for this gene makes more of the reddish melanin than the brownish melanin, resulting in red hair and pa le skin. DNA extracted from two Neanderthal fossils contains a mutated MC1R allele that has not yet been found in humans, To see how the. Neanderthal mutation affects the function of the MC1R gene, Carles Lalueza-Fox and her team introduced the allele into cultured monkey cells (FIGURE 26.1 6).
FIGURE 26.16 MC1R activity in monkey cells transgenic for an unmutated MClR gene, the Neanderthal MC1R allele or the gene for green fluorescent protein (GFP). GFP is- not related to MC1R.
What purpose do the cells with the gene for green fluorescent protein serve in this experiment?
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Bloom Syndrome Bloom syndrome is a rare genetic disorder. It is characterized by a short stature and a long narrow face with prominent nose and ears. There is also an increased sensitivity to light. People who have the disorder often develop rashes on their face, forearms, and hands when they have been exposed to the sun. In addition, these people often suffer from chronic obstructive pulmonary disorder (COPD) and have a higher chance of developing cancer.
The cause of this genetic disorder is a mutation in the BLM gene located on chromosome 15. The immediate effect of this mutation is that there is a defect in the functioning of the DNA helicase enzyme. The location of this gene on the chromosome is indicated above (yellow arrow).
What is the effect of this mutation on DNA replication?
What stage of the cell cycle would be most affected?
What is the answer
Original DNA Sequence:
TACAC CTTGG CGACGACT...
MRNA Sequence:
Amino Acid Sequence:
Mutated DNA Sequence #5 TACACCTT G G GACGACT... (Highlight the change)
What's the mRNA sequence?
What will be the amino acid sequence?
Will there likely be effects?
What type of mutation is this?
1. Which type of mutation is responsible for new variations of a trait?
2. Which type of mutation does not result in an abnormal amino acid sequence?
3.
Which type of mutation stops the translation of an mRNA molecule?
NO
Chapter 26 Solutions
Bundle: Biology: The Unity and Diversity of Life, Loose-leaf Version, 14th + LMS Integrated for MindTap Biology, 2 terms (12 months) Printed Access Card
Ch. 26 - New World monkeys _____. a. lack a tail b. are...Ch. 26 - The closest relatives of bonobos are ________. a....Ch. 26 - Prob. 3SQCh. 26 - Neanderthal Hair Color The MC1R gene regulates...Ch. 26 - Neanderthal Hair Color The MCIR gene regulates...Ch. 26 - Neanderthal Hair Color The MCIR gene regulates...Ch. 26 - Like most mammals, a(n) __________ has a wet nose....Ch. 26 - The 3.6-million-year-old footprints left by...Ch. 26 - The position where a spinal cord enters the skull...Ch. 26 - Australopiths are__________ a. extinct b....
Ch. 26 - The oldest Homo fossils found outside of Africa...Ch. 26 - A prominent chin is typical of _______. a. Homo...Ch. 26 - Compared to modern humans, Neanderthals had a...Ch. 26 - The oldest Homo sapiens fossils were found in...Ch. 26 - __________ probably had a spoken language. a....Ch. 26 - Modem people native to __________ have a higher...Ch. 26 - Match each group with its description. ___...Ch. 26 - Place the events in order. ___ 1 (earliest) a....Ch. 26 - Male aggression is rare in bonobo society and...Ch. 26 - Think about the pattern of human dispersal. Given...
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- Neanderthal Hair Color The MC1R gene regulates pigmentation in humans (Sections 14.1 and 15.1 revisited), so loss-of-function mutations in this gene affect hair and skin color. A person with two mutated alleles for this gene makes more of the reddish melanin than the brownish melanin, resulting in red hair and pale skin. DNA extracted from two Neanderthal fossils contains a mutated MC1R allele that has not yet been found in humans. To see how the Neanderthal mutation affects the function of the MC1R gene. Carles Lalueza-Fox and her team introduced the allele into cultured monkey cells (FIGURE 26.16). FIGURE 26.16 MC1R activity in monkey cells transgenic for an unmutated MC1R gene, the Neanderthal MC1R allele, or the gene for green fluorescent protein (GFP). GFP is not related to MC1R. 1. How did MCR1 activity in monkey cells with the mutant allele differ from that in cells with the normal allele?arrow_forwardWhat type of mutation is this? 1. Which type of mutation is responsible for new varia tions of a trait? Which type of mutation does not result in an abnormal amino acid sequece? Which type of mutation stops the translation of an mRNA molecule? 2. Sickle Cell Anemia Sickle cell anemia is the result of a type of mutation in the gene that codes for part of the hemoglobin molecule Hemoglobin carries oxygen in your red bloods cells. The mutation causes these red blood cells to become stife sickle-shaped when they release their oxygen. The sickled cells tend to get stuck in blood vessels, causing poin ond increased risk of stroke, blindness, damage to the heart & lungs, and other conditions. Analyze the DNA strands below to determine what amino acid is changed AND what type of mutation occurred Normal hemoglobin DNA A G TC Normal hemoglobin mRNA val• Hisolelo thr•proo Gll Normal hemoglobin AA sequence CA cGT AG A CTGAGG AC AC Sickle cell hemoglobin DNA Sickle cell hemoglobin mRNA Sickle cell…arrow_forwardUnanswered As a hobby you propagate a population of worms. You notice that one worm is now clear instead of being tan. You trace down the mutation and discover that it is a single basepair deletion in a pigmentation gene. Explain how a single basepair deletion could result in a drastic mutant phenotype. Your answer Write your response here... ion onarrow_forward
- Part B When a gene is duplicated resulting in two copies, there are three possible fates for the duplicate copy Sort each item to the appropriate bin. Potential to generate a new phenotype Most likely outcome for duplicated genes Pseudogene (Nonfunctionalization) 4 Both gene copies are required to carry out the functions of the original gene One gene copy is inactivated due to deleterious mutations Subfunctionalization Most interesting evolutionary outcome for duplicated genes Least likely outcome for duplicated genes Reset Help Neofunctionalizationarrow_forwardWhat phenotypes do you think a homozygous tra1hsn animal with a loss of function Egl-1 mutation would have.arrow_forwardGene Interaction and Epistasis Hair color is due to the presence of melanin. There are two types of melanin produced by melanocytes. One is eumelanin, which is responsible for black (homozygous), brown (heterozygous), and blond (recessive) hair colors. The other is pheomelanin, which is responsible for red hair color. During melanin synthesis, MCR1gene converts pheomelanin to eumelanin. However, a variant of the MCR1 gene (MCR1variant), prevents this conversion. A cross between a blond-haired mother and a red-haired father produced 100% brown-haired children. When they came of age, one child married a double heterozygote, and both were blessed with 7 children; 2 with black hair, 2 with brown hair, 1 with blond hair, and 2 with red hair. Using the 7-step method, determine the genotypes of the P1, the F1, and the F2s. BOX your answers (if handwritten) or HIGHLIGHT your answers (if encoded). STEP 1: ________________________________________________________ STEP 2:…arrow_forward
- The skin pigment melanin is expressed differently according to exposure to sunlight, with a greater production of the molecule with greater exposure. However, the degree of production can never exceed the inherited genetic level. What evolutionary advantage would be gained from having this phenotypic range for skin pigmentation?arrow_forwardVariations in Phenotype Expression A genetic disorder characterized by falling asleep in genetics lectures is known to be 20% penetrant. All 90 students in a genetics class are homozygous for this gene. Theoretically, how many of the 90 students will fall asleep during the next lecture?arrow_forwardOne unexpected result of the sequencing of the human genome was the finding that mutations in a single gene can be responsible for multiple distinct disorders. For example, mutations in the RET gene can cause two different types of multiple endocrine neoplasias, familial medullary thyroid carcinoma, and Hirschsprung disease. How do you think mutations in a single gene can have such diverse effects?arrow_forward
- 5-Azocytidine is an inhibitor of DNA methyltransferase. If thisdrug were fed to female mice during pregnancy, explain how youthink it would affect the coat color of offspring carrying the Avyallele.arrow_forwardSkin cancer is a disease that occurs when skin cells grow in an uncontrolled way it can be caused by UV light, which can cause alter the genetic sequence of skin cells. which choice below is the best describes how uv light might cause skin cancerarrow_forward1. (a)genes with similar function orthologous genes paralogous genes pseudogenes all of these (b) insulin genes in human and cow orthologous genes paralogous genes pseudogenes all of thesearrow_forward
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