HUMAN A+P MOD.MASTERING
2nd Edition
ISBN: 9780136919520
Author: AMERMAN
Publisher: PEARSON
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Chapter 26, Problem 21CYR
Summary Introduction
Introduction:
The permanent methods of contraception include the sterilization methods. These methods inhibit an individual from reproduction. They require expertise in surgery and hence cannot be performed without the help of medical assistance. The permanent methods are the best choice of contraception for couples who do not want any kids in the future.
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Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug:
(a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate)
(b) Estimate the time for maximum plasma concentration (tmax).
(c) Estimate the maximum plasma concentration (Cmax).
(d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.)
(e)…
Chapter 26 Solutions
HUMAN A+P MOD.MASTERING
Ch. 26.1 - 1. What are the male and female gonads? What are...Ch. 26.1 - Which mechanisms increase the genetic variability...Ch. 26.1 - Prob. 3QCCh. 26.1 - Prob. 4QCCh. 26.1 - Prob. 5QCCh. 26.1 - Prob. 6QCCh. 26.2 - Which cell type in the testes produces sperm?...Ch. 26.2 - Prob. 2QCCh. 26.2 - 3. What is the function of the epididymis? How...Ch. 26.2 - 4. Trace the pathway that sperm take from the...
Ch. 26.2 - Prob. 5QCCh. 26.2 - Prob. 6QCCh. 26.2 - Prob. 7QCCh. 26.2 - Prob. 8QCCh. 26.2 - Prob. 9QCCh. 26.2 - Which part of the duct system passes through the...Ch. 26.3 - What are the steps of spermatogenesis?Ch. 26.3 - How do sustentacular cells support developing...Ch. 26.3 - Prob. 3QCCh. 26.3 - Prob. 4QCCh. 26.3 - Prob. 5QCCh. 26.3 - On what type of cell do FSH and LH act in males,...Ch. 26.3 - 7. What are the reproductive functions of...Ch. 26.3 - Prob. 8QCCh. 26.3 - Prob. 9QCCh. 26.3 - Prob. 10QCCh. 26.3 - Prob. 11QCCh. 26.3 - Prob. 12QCCh. 26.3 - Prob. 13QCCh. 26.3 - Prob. 14QCCh. 26.4 - What are the main functions of the ovaries?Ch. 26.4 - Which three ligaments support the ovary, and to...Ch. 26.4 - What structures catch an ovulated oocyte and move...Ch. 26.4 - Prob. 4QCCh. 26.4 - Prob. 5QCCh. 26.4 - Prob. 6QCCh. 26.4 - Prob. 7QCCh. 26.4 - Prob. 8QCCh. 26.4 - Prob. 9QCCh. 26.4 - 10. How are the external genitalia of the female...Ch. 26.4 - 11. Which structures do not fully develop in the...Ch. 26.4 - Prob. 12QCCh. 26.5 - When in the life cycle of a female does oogenesis...Ch. 26.5 - When is development of an oocyte arrested, and...Ch. 26.5 - How many ova are produced at the end of oogenesis?...Ch. 26.5 - What are the seven stages of the ovarian cycle?...Ch. 26.5 - Prob. 5QCCh. 26.5 - Prob. 6QCCh. 26.5 - Prob. 7QCCh. 26.5 - Prob. 8QCCh. 26.5 - 9. How do levels of ovarian hormones and...Ch. 26.5 - What are the similarities between the male and...Ch. 26.5 - What are the differences between the male and...Ch. 26.5 - Prob. 12QCCh. 26.5 - What are the female secondary sex characteristics?Ch. 26.5 - Prob. 14QCCh. 26.5 - Prob. 15QCCh. 26.6 - 1. Why do most behavioral methods of birth...Ch. 26.6 - Prob. 2QCCh. 26.6 - How do oral contraceptive pills prevent pregnancy?Ch. 26.6 - Prob. 4QCCh. 26.6 - 5. How do intrauterine devices prevent...Ch. 26.6 - Which methods of birth control are also called...Ch. 26.7 - Prob. 1QCCh. 26.7 - Prob. 2QCCh. 26.7 - Prob. 3QCCh. 26.7 - Prob. 4QCCh. 26 - Prob. 1CYRCh. 26 - Match the specific phase of meiosis with the...Ch. 26 - Prob. 3CYRCh. 26 - Which of the following structures is the site of...Ch. 26 - Prob. 5CYRCh. 26 - Prob. 6CYRCh. 26 - Match the component of the glandular secretions...Ch. 26 - Prob. 8CYRCh. 26 - Prob. 9CYRCh. 26 - Prob. 10CYRCh. 26 - Prob. 11CYRCh. 26 - Prob. 12CYRCh. 26 - Prob. 13CYRCh. 26 - Prob. 14CYRCh. 26 - Prob. 15CYRCh. 26 - Mark the following statements about oogenesis as...Ch. 26 - Prob. 17CYRCh. 26 - 18. Number the sequence of events in the hormonal...Ch. 26 - 19. Mark the following statements about the...Ch. 26 - Prob. 20CYRCh. 26 - Prob. 21CYRCh. 26 - Prob. 22CYRCh. 26 - Prob. 1CYUCh. 26 - Prob. 2CYUCh. 26 - Prob. 3CYUCh. 26 - Explain why oral contraceptives, which...Ch. 26 - Prob. 1AYKACh. 26 - Prob. 2AYKACh. 26 - Prob. 3AYKACh. 26 - Prob. 4AYKB
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