ANATOMY AND PHYSIOLOGY
17th Edition
ISBN: 9781630180928
Author: OpenStax
Publisher: OPENSTAX C
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Textbook Question
Chapter 26, Problem 17RQ
Most of the body’s calcium is found in ________.
- teeth
- bone
- plasma
- extracellular fluids
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1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple different routes of administration provides greater insight than just a single route of administration alone. The following data was collected in 250 g rats following bolus iv, oral (po), and intraperitoneal (ip) administration.Using this data and set of graphs, determine:
(a) k, C0, V, and AUC* for the bolus iv data (b) k, ka, B1, and AUC* for the po data (c) k, ka, B1, and AUC* for the ip data (d) relative bioavailability for po vs ip, Fpo/Fip (e) absolute po bioavailability, (f)Fpo absolute ip bioavailability, Fip
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2. Drug quantification from plasma is commonly performed by using techniques such as HPLC or LC/MS. However, these methods do have limitations, and investigators may choose to use a radiolabeled analog of a drug instead. Radioligands are molecules that contain radioactive isotopes, commonly 3H or 14C. This technique allows investigators to quantify drug concentration from radiation measurements. The following measurements were made in 250 g rats following oral administration of 18.2 µCi of a 14C-labeled drug of interest: Time (min) Plasma Radiation Levels (µCi/L) 0 0.0 2 9.7 4 19.2 7 25.3 9 37.8 12 39.6 14 45.8 17 48.8 20 52.0 25 56.4 30 59.2 35 60.1 40 61.1 45 62.1 50 62.8 60 63.1 70 62.1 80 60.1 90 57.3 100 55.5 110 53.7 120 52.2 150 48.0 180 45.0 240 39.0
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The current nutrition labelling regulation in Hong Kong requires food manufacturer to list E+7 information on the package of pre-packaged food products. Do you think that more nutrients, such as calcium and cholesterol, shall be included?
Chapter 26 Solutions
ANATOMY AND PHYSIOLOGY
Ch. 26 - Watch this video...Ch. 26 - Watch this video...Ch. 26 - Read this article...Ch. 26 - Watch this video...Ch. 26 - Solute contributes to the movement of water...Ch. 26 - A cation has a(n) ________ charge. neutral...Ch. 26 - Interstitial fluid (IF) is ________. the fluid in...Ch. 26 - The largest amount of water comes into the body...Ch. 26 - The largest amount of water leaves the body via...Ch. 26 - Insensible water loss is water lost via ________....
Ch. 26 - How soon after drinking a large glass of water...Ch. 26 - Bone serves as a mineral reserve for which two...Ch. 26 - Electrolytes are lost mostly through ________....Ch. 26 - The major cation in extracellular fluid is...Ch. 26 - The major cation in intracellular fluid is...Ch. 26 - The major anion in extracellular fluid is...Ch. 26 - Most of the bodys calcium is found in ________....Ch. 26 - Abnormally increased blood levels of sodium are...Ch. 26 - The ion with the lowest blood level is ________....Ch. 26 - Which two ions are most affected by aldosterone?...Ch. 26 - Which of the following is the most important...Ch. 26 - Which explanation best describes why plasma...Ch. 26 - The buffer that is adjusted to control acid-base...Ch. 26 - Carbonic acid levels are controlled through the...Ch. 26 - Bicarbonate ion concentrations in the blood are...Ch. 26 - Which reaction is catalyzed by carbonic anhydrase?...Ch. 26 - Which of the following is a cause of metabolic...Ch. 26 - Which of the following is a cause of respiratory...Ch. 26 - At a pH of 7.40, the carbonic acid ratio is...Ch. 26 - Which of the following is characterized as...Ch. 26 - Plasma contains more sodium than chloride. How can...Ch. 26 - How is fluid moved from compartment to...Ch. 26 - Describe the effect of ADH on renal collecting...Ch. 26 - Why is it important for the amount of water intake...Ch. 26 - Explain how the CO2 generated by cells and exhaled...Ch. 26 - How can one have an imbalance in a substance, but...Ch. 26 - Describe the conservation of bicarbonate ions in...Ch. 26 - Describe the control of blood carbonic acid levels...Ch. 26 - Case Study: Bob is a 64-year-old male admitted to...Ch. 26 - Case Study: Kim is a 38-year-old women admitted to...
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