Chapter 25.SE, Problem 31MP

Interpretation Introduction

Interpretation:

To propose a mechanism of mannose 6-phosphate derivative from fructose 6-phosphate.

Concept introduction:

Acid-base Catalysis by the enzyme.

Step 1: Substrate binding.

Step 2: Acid catalyzed ring opening.

Step 3: Base abstracts the acidic proton from C2 to form a cis enediolete intermediate.

Step 4: proten is replaced on C-1 as ab iverall proton teamster.

Step 5: Ring disuse to form product.