Chapter 25.7, Problem 39CC

Interpretation Introduction

Interpretation:

The regions that are more likely to form $\beta$-pleated sheets in the given peptide need to be identified.

Concept introduction:

When two or more protein chain lines up side by side, beta pleated sheets are formed.  There are two types of beta pleated sheets, namely parallel and anti-parallel.  The beta pleated sheet is formed due to the hydrogen bonding between the carbonyl group and $\text{NH}$ group present in the two chains.  The beta sheets are usually formed if the protein chain contains the residue which has smaller side chains.  If the side chain is large in the residue then there will be steric hindrance which will prevent the chains from forming beta pleated sheets.

To identify : To identify the regions that are most likely to form beta pleated sheets.