The sequence of tripeptide that was synthesized using Merrifield synthesis has to be identified from the given scheme and both C- and N-terminus must be labeled. Concept introduction: Peptides can be synthesized in more yield by using the method developed by R. Bruce Merrifield. A peptide containing a large number of amino acid residue can be synthesized easily by this method. The coupling of the amino acid residues are done without purification. The key steps involved in Merrifield Synthesis are, Attachment of Boc-protected residue to polymer . Removal of Boc Protecting group. Coupling with another Boc-protected amino acid using DCC. For each amino acid that is added to the growing peptide chain removal of Boc and coupling is done. Removal of Boc and detachment of peptide from the polymer. To identify : To identify the tripeptide obtained from the given scheme and label the terminus.

Question

Want to see the full answer?

Answer 1

Question

Definition Definition Class of organic compounds that contain a carboxyl group ( - COOH ) and has a general formula R - COOH or R - CO 2 H , where R refers to the alkyl, alkenyl, aryl, or other groups. They can undergo different chemical reactions, such as acid-base reactions, esterification, and oxidation. These are essential components of living organisms, playing important roles in metabolic processes, signaling, and as pharmaceuticals.

Chapter 25.6, Problem 38ATS

Interpretation Introduction

Interpretation:

The sequence of tripeptide that was synthesized using Merrifield synthesis has to be identified from the given scheme and both C- and N-terminus must be labeled.

Concept introduction:

Peptides can be synthesized in more yield by using the method developed by R. Bruce Merrifield. A peptide containing a large number of amino acid residue can be synthesized easily by this method. The coupling of the amino acid residues are done without purification. The key steps involved in Merrifield Synthesis are,

Attachment of Boc-protected residue to polymer.

Removal of Boc Protecting group.

Coupling with another Boc-protected amino acid using DCC.

For each amino acid that is added to the growing peptide chain removal of Boc and coupling is done.

Removal of Boc and detachment of peptide from the polymer.

To identify : To identify the tripeptide obtained from the given scheme and label the terminus.

Expert Solution & Answer

Want to see the full answer?

Check out a sample textbook solution

See solution

Students have asked these similar questions

Given the first-order reaction: aA → products. State its kinetic equation.

Determine the symmetry of the combination of atomic orbitals for bf 4-

H Draw the product and the mechanism 1.) LDA + 2.) H30* H ○ excess OH

Answer 2

Question

Definition Definition Class of organic compounds that contain a carboxyl group ( - COOH ) and has a general formula R - COOH or R - CO 2 H , where R refers to the alkyl, alkenyl, aryl, or other groups. They can undergo different chemical reactions, such as acid-base reactions, esterification, and oxidation. These are essential components of living organisms, playing important roles in metabolic processes, signaling, and as pharmaceuticals.

Chapter 25.6, Problem 38ATS

Interpretation Introduction

Interpretation:

The sequence of tripeptide that was synthesized using Merrifield synthesis has to be identified from the given scheme and both C- and N-terminus must be labeled.

Concept introduction:

Peptides can be synthesized in more yield by using the method developed by R. Bruce Merrifield. A peptide containing a large number of amino acid residue can be synthesized easily by this method. The coupling of the amino acid residues are done without purification. The key steps involved in Merrifield Synthesis are,

Attachment of Boc-protected residue to polymer.

Removal of Boc Protecting group.

Coupling with another Boc-protected amino acid using DCC.

For each amino acid that is added to the growing peptide chain removal of Boc and coupling is done.

Removal of Boc and detachment of peptide from the polymer.

To identify : To identify the tripeptide obtained from the given scheme and label the terminus.

Expert Solution & Answer

Want to see the full answer?

Check out a sample textbook solution

See solution

Answer 3

Question

Definition Definition Class of organic compounds that contain a carboxyl group ( - COOH ) and has a general formula R - COOH or R - CO 2 H , where R refers to the alkyl, alkenyl, aryl, or other groups. They can undergo different chemical reactions, such as acid-base reactions, esterification, and oxidation. These are essential components of living organisms, playing important roles in metabolic processes, signaling, and as pharmaceuticals.

Chapter 25.6, Problem 38ATS

Interpretation Introduction

Interpretation:

The sequence of tripeptide that was synthesized using Merrifield synthesis has to be identified from the given scheme and both C- and N-terminus must be labeled.

Concept introduction:

Peptides can be synthesized in more yield by using the method developed by R. Bruce Merrifield. A peptide containing a large number of amino acid residue can be synthesized easily by this method. The coupling of the amino acid residues are done without purification. The key steps involved in Merrifield Synthesis are,

Attachment of Boc-protected residue to polymer.

Removal of Boc Protecting group.

Coupling with another Boc-protected amino acid using DCC.

For each amino acid that is added to the growing peptide chain removal of Boc and coupling is done.

Removal of Boc and detachment of peptide from the polymer.

To identify : To identify the tripeptide obtained from the given scheme and label the terminus.

Expert Solution & Answer

Want to see the full answer?

Check out a sample textbook solution

See solution

Answer 4

Question

Definition Definition Class of organic compounds that contain a carboxyl group ( - COOH ) and has a general formula R - COOH or R - CO 2 H , where R refers to the alkyl, alkenyl, aryl, or other groups. They can undergo different chemical reactions, such as acid-base reactions, esterification, and oxidation. These are essential components of living organisms, playing important roles in metabolic processes, signaling, and as pharmaceuticals.

Chapter 25.6, Problem 38ATS

Interpretation Introduction