HUMAN ANATOMY
6th Edition
ISBN: 9781260210262
Author: SALADIN
Publisher: RENT MCG
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Textbook Question
Chapter 25.2, Problem 5BYGO
Answer the following questions to test your understanding of the preceding section:
5. Concisely state the functions of the glomerulus, PCT, nephron loop, DCT, and collecting duct.
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Digoxin: Intravenous Bolus - Two Compartment Model
Drug
Digoxin
Route:
IV Bolus
Dose:
0.750 mg
Plasma Concentration Time Profile
Beta
Alpha
Time (hrs)
Conc (ng/ml)
LN
(ng/ml)
LN
(ng/ml)
LN
0.00
#NUM!
#NUM!
#NUM!
0.10
12.290
2.509
#NUM!
#NUMI
0.60
6.975
1.942
#NUM!
#NUMI
1.00
4.649
1.537
#NUM!
#NUMI
2.00
2.201
0.789
#NUM!
#NUM!
3.00
1.536
0.429
#NUM!
#NUM!
4.00
1.342
0.294
#NUM!
#NUM!
5.00
1.273
0.241
#NUM!
#NUMI
6.00
1.238
0.213
#NUM!
#NUM!
7.00
1.212
0.192
#NUM!
#NUM!
8.00
1.188
0.172
#NUMI
#NUM!
9.00
1.165
0.153
#NUM!
#NUMI
10.00
1.143
0.134
#NUMI
#NUM!
11.00
1.122
0.115
#NUM!
12.00
1.101
0.096
#NUMI
13.00
1.080
0.077
#NUMI
16.00
1.020
0.020
#NUMI
24.00
0.876
-0.132
#NUMI
Pharmacokinetic Parameters
Parameter
Value
Alpha
B
Beta
Units
ng/ml
hr-1
ng/ml
hr-1
CO
ng/ml
H.C
AUC
ng x hr/ml
Vc
Vbeta
Vss
C
L/hr
TK (alpha)
hr
TX (beta)
days
5+
F3
F4
F5
0+
F6
F7
%
6
95
14
#3
29
&
t
F8
F9
FW
EW
Linuron, a derivative of urea, is used as an herbicide. Linuron serum levels were measured in 4Kg
rabbits following a bolus IV injection of 10mg/kg.
Time (minutes)
Serum Linuron Levels (ug/ml)
following IV dose
10
15.48
20
8.60
30
5.90
45
3.78
60
2.42
90
1.49
120
0.93
180
0.60
240
0.41
300
0.29
360
0.22
Analyze this data and perform the necessary calculations to determine the following pharmacokinetic
parameters from the IV data: (5 points per parameter, 24 parameters/variables ■ 120 points
possible). You do NOT need to submit graphs or data tables.
Give the terminal regression line equation and R or R² value:
Give the x axis (name and units, if any) of the terminal line:
Give the y axis (name and units, if any) of the terminal line:
Give the residual regression line equation and R or R² value:
Give the x axis (name and units, if any) of the residual line:
Give the y axis (name and units, if any) of the residual line:
Chapter 25 Solutions
HUMAN ANATOMY
Ch. 25.1 - Prob. 1BYGOCh. 25.1 - Answer the following questions to test your...Ch. 25.2 - Prob. 1AWYKCh. 25.2 - Prob. 2AWYKCh. 25.2 - Prob. 3BYGOCh. 25.2 - Prob. 4BYGOCh. 25.2 - Answer the following questions to test your...Ch. 25.2 - Answer the following questions to test your...Ch. 25.2 - Prob. 7BYGOCh. 25.3 - Prob. 8BYGO
Ch. 25.3 - Prob. 9BYGOCh. 25.3 - Prob. 10BYGOCh. 25.3 - Prob. 11BYGOCh. 25.4 - Prob. 12BYGOCh. 25.4 - Prob. 13BYGOCh. 25.4 - Prob. 14BYGOCh. 25.4 - Prob. 15BYGOCh. 25 - Prob. 25.1.1AYLOCh. 25 - Prob. 25.1.2AYLOCh. 25 - Prob. 25.1.3AYLOCh. 25 - To test your knowledge, discuss the following...Ch. 25 - Prob. 25.2.1AYLOCh. 25 - Prob. 25.2.2AYLOCh. 25 - To test your knowledge, discuss the following...Ch. 25 - Prob. 25.2.4AYLOCh. 25 - Prob. 25.2.5AYLOCh. 25 - Prob. 25.2.6AYLOCh. 25 - Prob. 25.2.7AYLOCh. 25 - To test your knowledge, discuss the following...Ch. 25 - To test your knowledge, discuss the following...Ch. 25 - To test your knowledge, discuss the following...Ch. 25 - Prob. 25.2.11AYLOCh. 25 - To test your knowledge, discuss the following...Ch. 25 - Prob. 25.2.13AYLOCh. 25 - To test your knowledge, discuss the following...Ch. 25 - Prob. 25.2.15AYLOCh. 25 - To test your knowledge, discuss the following...Ch. 25 - Prob. 25.3.1AYLOCh. 25 - Prob. 25.3.2AYLOCh. 25 - To test your knowledge, discuss the following...Ch. 25 - Prob. 25.4.1AYLOCh. 25 - Prob. 25.4.2AYLOCh. 25 - Prob. 25.4.3AYLOCh. 25 - Prob. 25.4.4AYLOCh. 25 - Prob. 25.4.5AYLOCh. 25 - To test your knowledge, discuss the following...Ch. 25 - Prob. 25.4.7AYLOCh. 25 - Prob. 1TYRCh. 25 - Prob. 2TYRCh. 25 - Prob. 3TYRCh. 25 - Prob. 4TYRCh. 25 - Prob. 5TYRCh. 25 - A glomerulus and glomerular capsule make up one...Ch. 25 - Prob. 7TYRCh. 25 - Prob. 8TYRCh. 25 - The absorbs variable amounts of water depending on...Ch. 25 - In cortical nophrons, blood of the efferent...Ch. 25 - Prob. 11TYRCh. 25 - Prob. 12TYRCh. 25 - The openings of the two ureters and the urehra...Ch. 25 - Prob. 14TYRCh. 25 - To enter the capsular space, filterate must pass...Ch. 25 - Prob. 16TYRCh. 25 - Prob. 17TYRCh. 25 - Prob. 18TYRCh. 25 - Prob. 19TYRCh. 25 - Prob. 20TYRCh. 25 - Prob. 1BYMVCh. 25 - Prob. 2BYMVCh. 25 - Prob. 3BYMVCh. 25 - Prob. 4BYMVCh. 25 - Prob. 5BYMVCh. 25 - Prob. 6BYMVCh. 25 - Prob. 7BYMVCh. 25 - Prob. 8BYMVCh. 25 - Prob. 9BYMVCh. 25 - Prob. 10BYMVCh. 25 - Prob. 1WWWTSCh. 25 - Prob. 2WWWTSCh. 25 - Briefly explain why each ofthe followingstatements...Ch. 25 - Prob. 4WWWTSCh. 25 - Prob. 5WWWTSCh. 25 - Prob. 6WWWTSCh. 25 - Prob. 7WWWTSCh. 25 - Prob. 8WWWTSCh. 25 - Prob. 9WWWTSCh. 25 - Prob. 10WWWTSCh. 25 - Prob. 1TYCCh. 25 - Prob. 2TYCCh. 25 - Prob. 3TYCCh. 25 - Prob. 4TYCCh. 25 - Prob. 5TYC
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