Chapter 25, Problem 3P

Regulation of Glutamine Synthetase by Covalent Modification Suppose at certain specific metabolite concentrations in vivo the cyclic cascade regulating E. coli glutamine synthetase has reached a dynamic equilibrium where the average state of GS adenylylation is poised at $n=6$. Predict what change in $n$will occur if:

$\left[\text{ATP}\right]$

1. increases,

${\text{P}}_{\text{IIA}}/{\text{P}}_{\text{IID}}$

1. increases,

$\left[\alpha \text{-KG}\right]/\left[\text{Gln}\right]$

1. increases,

$\left[{\text{P}}_{\text{i}}\right]$

1. decreases.