Campbell Biology: Concepts & Connections (8th Edition)
Campbell Biology: Concepts & Connections (8th Edition)
8th Edition
ISBN: 9780321885326
Author: Jane B. Reece, Martha R. Taylor, Eric J. Simon, Jean L. Dickey, Kelly A. Hogan
Publisher: PEARSON
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Chapter 25, Problem 25TYK

Scientists have found that the quantity of aquaporin molecules inserted in the membranes of collecting duct cells changes in response to ADH levels. Draw a line graph proposing a relationship between ADH levels and its effect on the quantity of - aquaporins. Additionally, explain how the relationship between ADH and aquaporins corresponds to situations of dehydration and hydration.

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One model of the glomerular membrane is a microporous membrane in which right cylindrical pores penetrate all the way through the membrane. Assume that the pores have a length of 50 nm and a radius of 3.5 nm. The viscosity of plasma is 0.002 Pa s. The average hydrostatic pressure in the glomerulus is 60 mm Hg, hydrostatic pressure in Bowman's space is 20 mm Hg and the average oncotic pressure of glomerular capillary blood is 28 mm Hg. A. Calculate the flow through a single pore assuming laminar flow (use the Poiseuille flow equation) B. How many pores would there have to be to produce a normal GFR? C. If the total aggregate area of the kidneys for filtration is 1.5 m2, what is the density of the pores (number of pores per unit area)? D. What fraction of the area is present as pores?
Describe the actions of aquaporins. Which aquaporins are always present and where and which are only present when stimulated by ADH and where.
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