Foundations in Microbiology
9th Edition
ISBN: 9780073522609
Author: Kathleen Park Talaro, Barry Chess Instructor
Publisher: McGraw-Hill Education
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Chapter 24.3, Problem 11ELO
Understand the etiological agent, epidemiology, diagnosis, and control of varicella-zoster virus, cytomegalovirus, and Epstein-Barr virus.
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Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug:
(a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate)
(b) Estimate the time for maximum plasma concentration (tmax).
(c) Estimate the maximum plasma concentration (Cmax).
(d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.)
(e)…
Chapter 24 Solutions
Foundations in Microbiology
Ch. 24.1 - Prob. 1ELOCh. 24.1 - Prob. 2ELOCh. 24.1 - Explain how viral structure is related to viral...Ch. 24.1 - Discuss the structures found in a typical virus.Ch. 24.1 - Differentiate among lytic infection, latent...Ch. 24.1 - Relate the importance of structure to viral...Ch. 24.1 - What accounts for the affinity of viruses for...Ch. 24.1 - What accounts for the symptoms of viral diseases?Ch. 24.1 - In what ways can people carry viruses?Ch. 24.2 - Prob. 4ELO
Ch. 24.2 - Understand why vaccination against smallpox has...Ch. 24.2 - Prob. 6ELOCh. 24.2 - What structural attributes differentiate smallpox...Ch. 24.2 - Prob. 8CYPCh. 24.2 - Prob. 9CYPCh. 24.3 - Prob. 7ELOCh. 24.3 - Prob. 8ELOCh. 24.3 - Prob. 9ELOCh. 24.3 - Prob. 10ELOCh. 24.3 - Understand the etiological agent, epidemiology,...Ch. 24.3 - Prob. 12ELOCh. 24.3 - Prob. 13ELOCh. 24.3 - Prob. 10CYPCh. 24.3 - Prob. 11CYPCh. 24.3 - Describe the ways in which HSV-1 differs from...Ch. 24.3 - Prob. 13CYPCh. 24.3 - Prob. 14CYPCh. 24.3 - Prob. 15CYPCh. 24.3 - Summarize the signs, symptoms, and epidemiology...Ch. 24.3 - What cancers are related to infection with...Ch. 24.3 - Prob. 18CYPCh. 24.4 - Contrast the major characteristics of the three...Ch. 24.4 - Understand the epidemiology, diagnosis, pathology,...Ch. 24.4 - Prob. 19CYPCh. 24.4 - Prob. 20CYPCh. 24.4 - What groups are most at risk for developing...Ch. 24.4 - What is the nature of the vaccines for hepatitis...Ch. 24.5 - Recall the structure, epidemiology, and diseases...Ch. 24.5 - Prob. 17ELOCh. 24.5 - Prob. 18ELOCh. 24.5 - Prob. 19ELOCh. 24.5 - Prob. 20ELOCh. 24.5 - Prob. 21ELOCh. 24.5 - Prob. 23CYPCh. 24.5 - Prob. 24CYPCh. 24.5 - Prob. 25CYPCh. 24.5 - What is the importance of the HPV vaccines?Ch. 24.5 - Prob. 27CYPCh. 24.5 - Prob. 28CYPCh. 24.L1 - Prob. 1MCQCh. 24.L1 - Prob. 2MCQCh. 24.L1 - Which virus is used in smallpox vaccination? a....Ch. 24.L1 - Prob. 4MCQCh. 24.L1 - Prob. 5MCQCh. 24.L1 - Prob. 6MCQCh. 24.L1 - _____ is an effective treatment for herpes simplex...Ch. 24.L1 - Which herpesvirus is most commonly associated with...Ch. 24.L1 - Prob. 9MCQCh. 24.L1 - A common sign of hepatitis is a. liver cancer b....Ch. 24.L1 - Prob. 11MCQCh. 24.L1 - Prob. 12MCQCh. 24.L1 - Parvoviruses are unique because they contain a. a...Ch. 24.L1 - Adenoviruses are the agents of a. hemorrhagic...Ch. 24.L1 - Prob. 15MCQCh. 24.L1 - Prob. 16MCQCh. 24.L1 - Prob. 17MCQCh. 24.L1 - Prob. 1CSRCh. 24.L1 - Aggressive vaccination campaigns have led to the...Ch. 24.L1 - Prob. 3CSRCh. 24.L1 - Prob. 1WCCh. 24.L1 - Explain the involvement of viruses in cancer and...Ch. 24.L1 - Prob. 3WCCh. 24.L1 - Develop a table for the herpesviruses that...Ch. 24.L1 - Prob. 5WCCh. 24.L1 - Prob. 6WCCh. 24.L1 - Prob. 7WCCh. 24.L2 - Prob. 1CTCh. 24.L2 - Describe several measures health care workers can...Ch. 24.L2 - Prob. 3CTCh. 24.L2 - Prob. 4CTCh. 24.L2 - a. Name two different defective viruses that...Ch. 24.L2 - Prob. 6CTCh. 24.L2 - A man wants to divorce his wife because he...Ch. 24.L2 - Weigh the following observation: High titers of...Ch. 24.L2 - Give some pros and cons of exposing children to...Ch. 24.L2 - Prob. 10CTCh. 24.L2 - What two different DNA viral infections can be...Ch. 24.L2 - Prob. 1VC
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