Anatomy & Physiology: The Unity of Form and Function
9th Edition
ISBN: 9781260791563
Author: Kenneth S. Saladin
Publisher: Mcgraw-hill Higher Education (us)
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Chapter 24.2, Problem 1AYLO
Functions of electrolytes in general: the body's common electrolytes: and the relative ECF and ICF concentrations of Na+, K+, Cl–, Ca2+, Ma2+, and phosphate ions
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Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug:
(a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate)
(b) Estimate the time for maximum plasma concentration (tmax).
(c) Estimate the maximum plasma concentration (Cmax).
(d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.)
(e)…
Chapter 24 Solutions
Anatomy & Physiology: The Unity of Form and Function
Ch. 24.1 - List five routes of water loss. Which one accounts...Ch. 24.1 - Prob. 2BYGOCh. 24.1 - Prob. 3BYGOCh. 24.1 - Summarize the effect of ADH on total body water...Ch. 24.1 - Prob. 5BYGOCh. 24.1 - Prob. 1AYLOCh. 24.1 - Prob. 2AYLOCh. 24.1 - What it means to be in a state of fluid balanceCh. 24.1 - Prob. 4AYLOCh. 24.1 - Prob. 5AYLO
Ch. 24.1 - Prob. 6AYLOCh. 24.1 - Prob. 7AYLOCh. 24.1 - Prob. 8AYLOCh. 24.1 - Prob. 9AYLOCh. 24.1 - Prob. 10AYLOCh. 24.1 - Prob. 11AYLOCh. 24.2 - Prob. 6BYGOCh. 24.2 - Prob. 7BYGOCh. 24.2 - Prob. 8BYGOCh. 24.2 - Prob. 9BYGOCh. 24.2 - Prob. 10BYGOCh. 24.2 - Prob. 11BYGOCh. 24.2 - Functions of electrolytes in general: the body's...Ch. 24.2 - Physiological function of sodium; how it is...Ch. 24.2 - Physiological functions of potassium; how it is...Ch. 24.2 - Prob. 4AYLOCh. 24.2 - Prob. 5AYLOCh. 24.2 - Prob. 6AYLOCh. 24.2 - Prob. 7AYLOCh. 24.3 - Prob. 12BYGOCh. 24.3 - Prob. 13BYGOCh. 24.3 - Prob. 14BYGOCh. 24.3 - Prob. 15BYGOCh. 24.3 - Prob. 1AYLOCh. 24.3 - Prob. 2AYLOCh. 24.3 - Prob. 3AYLOCh. 24.3 - How the bicarbonate, phosphate, and protein buffer...Ch. 24.3 - Prob. 5AYLOCh. 24.3 - How the renal tubule secretes acid; why urine is...Ch. 24.3 - Prob. 7AYLOCh. 24.3 - Prob. 8AYLOCh. 24.3 - Prob. 9AYLOCh. 24.3 - The difference between compensated and...Ch. 24.3 - Prob. 11AYLOCh. 24 - The greatest percentage of the bodys water is in...Ch. 24 - Prob. 2TYRCh. 24 - increases water reabsorption without increasing...Ch. 24 - Prob. 4TYRCh. 24 - Prob. 5TYRCh. 24 - The principal determinant of intracellular...Ch. 24 - Prob. 7TYRCh. 24 - Prob. 8TYRCh. 24 - Prob. 9TYRCh. 24 - Hyperchloremia is most likely to result in a....Ch. 24 - The most abundant cation in the ECF is __________.Ch. 24 - Prob. 12TYRCh. 24 - Water produced by the bodys chemical reactions is...Ch. 24 - Prob. 14TYRCh. 24 - Any abnormal accumulation of fluid in a particular...Ch. 24 - An excessive concentration of potassium ions in...Ch. 24 - Prob. 17TYRCh. 24 - Prob. 18TYRCh. 24 - Prob. 19TYRCh. 24 - Long-term satiation of thirst depends on a...Ch. 24 - Prob. 1BYMVCh. 24 - Prob. 2BYMVCh. 24 - Prob. 3BYMVCh. 24 - Prob. 4BYMVCh. 24 - Prob. 5BYMVCh. 24 - para-Ch. 24 - Prob. 7BYMVCh. 24 - Prob. 8BYMVCh. 24 - Prob. 9BYMVCh. 24 - vol-Ch. 24 - Prob. 1WWTSCh. 24 - Prob. 2WWTSCh. 24 - Prob. 3WWTSCh. 24 - The phosphate level in the ECF is very crucial to...Ch. 24 - Prob. 5WWTSCh. 24 - Prob. 6WWTSCh. 24 - Prob. 7WWTSCh. 24 - Prob. 8WWTSCh. 24 - In true dehydration, the body fluids remain...Ch. 24 - Prob. 10WWTSCh. 24 - Prob. 1TYCCh. 24 - Prob. 2TYCCh. 24 - Prob. 3TYCCh. 24 - Prob. 4TYCCh. 24 - Prob. 5TYC
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