
Concept explainers
To determine: The probability of the child being affected by FAP if both the parents are normal but the father’s sister has experienced the FAP.
Introduction: Familial adenomatous polyposis (FAP) is a form of colorectal cancer. This cancer is a result of a mutation in a specific gene called APC gene adenomatous polyposis coli. The symptom of this type of cancer is mainly visible in the early adolescence or later stages of life. This type of cancer is autosomal dominant and requires a single allele for producing cancerous cells.
To determine: The tests that can be helpful in the assessment.
Introduction: Familial adenomatous polyposis (FAP) is a condition that results due to the mutation in the APC gene present on the 5q chromosome and is an inheritance type of cancer. The polyps grown are initially noncancerous, but if the colonial polyps are left for a long time, these polyps may become malignant.

Want to see the full answer?
Check out a sample textbook solution
Chapter 24 Solutions
Concepts of Genetics (12th Edition)
- 1. Match each vocabulary term to its best descriptor A. affinity B. efficacy C. inert D. mimic E. how drugs move through body F. how drugs bind Kd Bmax Agonist Antagonist Pharmacokinetics Pharmacodynamicsarrow_forward50 mg dose of a drug is given orally to a patient. The bioavailability of the drug is 0.2. What is the volume of distribution of the drug if the plasma concentration is 1 mg/L? Be sure to provide units.arrow_forwardDetermine Kd and Bmax from the following Scatchard plot. Make sure to include units.arrow_forward
- Choose a catecholamine neurotransmitter and describe/draw the components of the synapse important for its signaling including synthesis, packaging into vesicles, receptors, transporters/degradative enzymes. Describe 2 drugs that can act on this system.arrow_forwardThe following figure is from Caterina et al. The capsaicin receptor: a heat activated ion channel in the pain pathway. Nature, 1997. Black boxes indicate capsaicin, white circles indicate resinferatoxin. a) Which has a higher potency? b) Which is has a higher efficacy? c) What is the approximate Kd of capsaicin in uM? (you can round to the nearest power of 10)arrow_forwardWhat is the rate-limiting-step for serotonin synthesis?arrow_forward
- Human Heredity: Principles and Issues (MindTap Co...BiologyISBN:9781305251052Author:Michael CummingsPublisher:Cengage LearningBiology (MindTap Course List)BiologyISBN:9781337392938Author:Eldra Solomon, Charles Martin, Diana W. Martin, Linda R. BergPublisher:Cengage Learning


